How do cells sense metabolites to drive their growth and proliferation?  We seek to study metabolites not only as nutrients but as cellular instruction signals that dictate cell biology. 

Malter Lab focuses on exploring and characterizing intracellular signaling pathways in the immune and nervous systems and identifying how defects/abnormalities can lead to disease.

The Zhang Lab studies intra- and inter-molecular interactions to understand how signaling proteins are regulated, using biochemistry, X-ray crystallography, cryo-EM and cell biology.