The Wang lab applies single-molecule fluorescence biophysical, quantitative biochemical, structural, and genetics approaches to unravel the intricate relationships between structure, dynamics and function in complex dynamic biological systems. Our primary goal is to understand the dynamic mechanisms of cytosolic and mitochondrial protein synthesis and how they are dysregulated in human diseases.

The Tu Lab is investigating how a variety of cellular processes and decisions are coordinated with metabolic state, and how the dysregulation of these mechanisms might be linked to disease and aging.

The overarching goals of our lab are to understand the posttranscriptional mechanisms of gene expression and regulation in the Kaposi's sarcoma-associated herpesvirus (KSHV) and its human host cell. We are particularly focused on the mechanisms and regulation of nuclear RNA stability, polyadenylation, and mRNA processing by viral and by host cell factors.