The Kraus Lab is interested in the basic mechanisms of nuclear signaling and gene regulation by small molecules and how these signaling pathways relate to human physiology and disease states.

The Harbour Lab uses genomic technologies and genetically engineered human cells and mouse models to develop biomarkers and elucidate mechanisms of tumor evolution and metastasis in uveal melanoma and retinoblastoma.

We are interested in understanding the deregulation of epigenetic and transcriptional pathways in human disease and in finding small molecules with therapeutic potential to normalize these gene expression patterns. 

We employ a variety of methods including evolutionary analysis, genomics, and molecular biology to study the biology of infection.

My lab has a long-time interest in understanding the mechanisms of transcription and gene regulation in mammalian cells using initially cell-free systems reconstituted with purified gene-specific transcription factors, general cofactors, and components of the general transcription machinery to recapitulate transcriptional events in vitro.