The Zechner Lab applies molecular and cell biology techniques to investigate how mammalian cells regulate their phosphate homeostasis and sensing using the ubiquitous phosphate transporter PiT1/SLC20A1 as a model.

The overarching goal of the Liu Lab is to redefine membrane enzymology.

The Luo lab studies hypoxia stress in human cancers with a focus on epigenetic and metabolic alterations. 

We are interested in how epithelial tissues sense and respond to injury.

We believe that understanding the basic biology of the schistosomes is key to developing the next generation of anti-schistosome drugs and vaccines. We also contend that by studying the basic biology of these fascinating organisms, we can better understand important basic biological processes common to all animals, including humans. For that reason, we study schistosomes from multiple angles using a variety of modern molecular approaches.of the lab. 

The over-arching theme of the Weaver Lab is to deeply understand how proteolytic factors mediate diverse physiological functions.

We investigate genetic and molecular basis of phenotypic diversity observed in nature by using a range of methodologies such as whole genome sequencing, fluidics, long-term evolution experiments, and large-scale combinatorial mutagenesis. 

What are the causes and consequences of cytoskeletal diversification?

We investigate the mechanism of neurotransmitter release using a variety of biophysical approaches, including NMR spectroscopy, X-ray crystallography, cryo-EM, molecular dynamics simulations and liposome fusion assays.

Our lab is broadly focused on the cellular signaling that drives the interactions between the intracellular parasite Toxoplasma gondii and its varied hosts.