The Moe Lab specializes in translational pathophysiology that spans from individual molecules, in vitro cell models, in vivo animal models, to metabolic human studies. 

We use in vivo models of ischemic acute kidney injury in mice, and in vitro model systems to perform detailed studies of proinflammatory genes activated by renal ischemia/reperfusion.

Our research is focused on mechanisms underlying acute kidney injury and sepsis.  Our laboratory has implicated mitochondrial maintenance via PGC1alpha and NAD+ as a novel pathway for resilience against acute physiological stressors.