Our mission is to advance biomedical knowledge in Multiple Sclerosis and support investigators in Neurology using best practices and comprehensive biostatistics expertise.

We use neuroimaging, neuromodulation, and behavioral experimentation to elucidate the brain circuits and mechanisms that support language and cognition, and to understand how these circuits differ in neurodevelopmental conditions such as autism. We are particularly interested in the role of cerebro-cerebellar circuits in language and cognition across development and disorders.

Dr. Coughlin's Brain Health Program research focuses on molecular neuroimaging techniques, particularly the use of novel radiotracers with positron emission tomography (PET). Her team aims to inform the molecular understanding of neuropsychiatric conditions, and identify novel, precision therapies guided by imaging results. 

Our lab specializes in clinical and research informatics, with a diverse portfolio of projects that leverage electronic health record (EHR) data and multimodal research data to enhance clinical care and advance research in the neurosciences.

In our lab, we focus on the mechanisms of cerebrovascular reactivity, exploring how blood vessels in the brain respond to changes in carbon dioxide, blood pressure, and other stimuli. 

The Ishii Laboratory is interested in understanding the bidirectional relationship between brain function and systemic metabolism with an emphasis on metabolic deficits in Alzheimer’s disease and how it differs from normal aging. Our laboratory focuses on generating hypotheses derived from open questions in clinical neurology and neuroendocrinology, testing these hypotheses using molecular genetics and neuroscience techniques in the laboratory, and whenever possible verifying these findings in clinically relevant human research studies. 

MUDIA Lab is focused on developing novel quantitative MRI techniques and analysis methods on CNS and musculoskeletal system. 

The Varadarajan Lab is interested in rebuilding neural circuits and restoring sensory function impaired by injury or disease.

The Lin Lab studies the transformation of brief experiences into enduring memories, their impact on behaviors, and the differing responses seen in both healthy and diseased conditions. Utilizing a multidisciplinary approach, our research explores how experience-induced genetic programs establish connections between experiences and synaptic modifications within neural circuits, ultimately driving persistent behavioral changes.

Interventional psychiatry is treatment that combines brain stimulation with medication for difficult-to-treat mental health disorders. At UT Southwestern Medical Center, our psychiatrists have advanced training and expertise in caring for people with treatment-resistant mental health disorders.

We specialize in the latest advances in brain stimulation to bring relief to people who haven’t had success with traditional treatments.