The Cobb lab studies signal transduction mechanisms of protein kinases and how kinase structures lead to cell biological functions. We are particularly focused on the contributions of ERK MAP kinases to pancreatic beta-cell function and to lung cancers, and on the cell biological actions of WNK protein kinases.

The Reddy Lab focuses on restoring effective antigen presentation to enhance anti-tumor immunity in breast cancers.

The overall focus of the Ram Mani Lab is to study the molecular genetic and epigenetic events associated with cancer development.

Shay Lab is interested in the relationships between aging and cancer and have focused on the role of the telomeres and telomerase in these processes.

The Sorrell Laboratory utilizes integrative approaches that include metabolomics, transcriptomics, organoid cultures, live microcopy, and animal models, to investigate fundamental pathways that control the uptake of nutrients and the biosynthesis of macromolecules in proliferative cells.

Akbay Lab studies genetic and molecular events that lead to lung-tumor initiation and immune evasion. 

The Seemann Lab studies the molecular mechanisms governing the function and inheritance of the mammalian Golgi apparatus.

Zaki Lab's research focuses on the the study of gastrointestinal inflammation and cancer.

Mukhopadhyay Lab research aims to understand how the primary cilium regulates downstream pathways to ultimately drive morphogenesis in different tissues. We undertake a multi-pronged approach including proteomics, cell biology, biochemistry, reverse genetics, and generation of innovative mouse models to study regulation of signaling pathways by cilia in in cellular and organismal contexts.

The ultimate goal of the Kittler Lab's research is to develop novel therapeutic approaches that target transcription factors, which play important roles in common solid tumors (brain, breast, lung and prostate cancer) and could therefore have translational potential.