Mukhopadhyay Lab research aims to understand how the primary cilium regulates downstream pathways to ultimately drive morphogenesis in different tissues. We undertake a multi-pronged approach including proteomics, cell biology, biochemistry, reverse genetics, and generation of innovative mouse models to study regulation of signaling pathways by cilia in in cellular and organismal contexts.
The ultimate goal of the Kittler Lab's research is to develop novel therapeutic approaches that target transcription factors, which play important roles in common solid tumors (brain, breast, lung and prostate cancer) and could therefore have translational potential.
The Arteaga laboratory has a longstanding interest in understanding the molecular pathways that drive breast cancer progression and influence response to therapies.
Our lab is using various approaches to explore this biology and develop new treatments with a focus on targeting tumor intrinsic factors such as genetic programs like the epithelial to mesenchymal transition that coordinate with infiltrating immune cells in enhance therapeutic resistance and assist distant spread.
Our laboratory is interested in the molecular mechanisms governing cytokine receptor signal transduction in hematopoietic stem and progenitor cells, and understanding how deregulation in these mechanisms results in hematological malignancies and cancer.
Publications for Dr. Emina Huang's Lab
Jer-Tsong Hsieh Lab research interests focus on key molecular mechanisms leading to urologic cancer progression, development of precision medicine of cancer therapy assisted with non-invasive molecular imaging.
The McFadden Lab uses genetically engineered mice and human cancer cells to identify new genes and small molecules that regulate cancer cell growth.
The Harbour Lab uses genomic technologies and genetically engineered human cells and mouse models to develop biomarkers and elucidate mechanisms of tumor evolution and metastasis in uveal melanoma and retinoblastoma.
The Wu Lab focuses on understanding the molecular pathways that govern T cell differentiation and function during infection and cancer.
