Translational biophotonics for noninvasive detection of systemic disease.

The Institute for Exercise and Environmental Medicine is a 40,000 square-foot research facility with 12 UTSW faculty working in multiple departments and divisions (Internal Medicine/Cardiology/Pulmonary, Neurology, PM&R, Anesthesiology, Applied Physiology) with up to 20 postdocs, and 40 staff on 70 active protocols and 15 federal grants. It is a research enterprise devoted to the study of human physiology and the limits to human functional capacity in health and disease. 

We investigate the neuro-hormonal basis for complex eating behaviors and blood glucose control, with the ultimate goal of designing new methods to prevent and treat extremes of body weight, blood glucose, and associated disorders of mood and metabolism.

Our lab is interested in understanding the relationship between injury, regeneration, and cancer. We are focused on identifying the genes and mechanisms that regulate regenerative capacity in the liver and understanding how these contribute to hepatocellular carcinoma development.

We are interested in how metabolism regulates various behaviors. We use two invertebrate model systems of C. elegans and D. melanogaster, ultimately aiming to unveil conserved neuro-molecular mechanisms throughout animals including mammals.

We are interested in understanding at a cellular level the neural control of energy balance and glucose metabolism, and elucidating how these events may participate in human disease.

The main focus in our laboratory is the identification and physiological characterization of adipocyte-specific gene products and the elucidation of pathways that are an integral part of the complex set of reactions that drive adipogenesis.

We are interested in the molecular mechanisms by which nuclear hormone receptors regulate lipid and carbohydrate metabolism in the liver, intestine, pancreatic islet, and central nervous system.

The mission of the Najafov Lab is to understand the role of cell death in physiology and disease. Our research is focused on necroptosis and how it can be targeted to develop novel strategies for treating cancer.

The Munshi Lab is a dedicated group of scientists seeking to identify the molecular drivers of normal cardiac rhythm and disease-associated dysrhythmias.