Research in Dr. Crandall's Thermal and Vascular Physiology Laboratory focuses on neural control of the cardiovascular system and how different stressors influence that control in healthy, diseased, and injured individuals, such as:

• Identifying the consequences of severe burn injuries and subsequent skin grafting on the ability of the burn survivor to regulate internal temperature and cardiovascular function.
• Understanding the consequences of aging on cardiovascular stress during simulated heat waves.
• Exploring cooling modalities to attenuate thermal and cardiovascular stress.
• Understanding how analgesics used on the battlefield affect autonomic control of blood pressure during hemorrhage.

Our laboratory has a particular interest in hepatic metabolism and its regulation by the immune system. We utilize genetic, epigenetic and proteomic approaches, combined with detailed physiological studies, to understand the complex mechanisms that causally link inflammation to metabolic dysfunction in obesity and fatty liver disease.

Preventing Cognitive Decline by Reducing Blood Pressure Target Trial (PCOT)
Researchers at UT Southwestern Medical Center are doing a study to prevent cognitive decline in adults by reducing blood pressure.

The CDR Collaborative studies last mile delivery problems across the cancer control continuum to develop and implement solutions.

We are broadly interested in how energy is regulated on a systems level during infection. Our current projects are focused on understanding the role that adipose tissue plays in the response to influenza and SARS-CoV2.

The Beckham lab is a dynamic multidisciplinary laboratory that studies viral pathogenesis and neuroimmune responses.

A major focus of the Horton lab is to determine how these transcriptional regulators contribute to the development of steatosis in various disease processes such as diabetes, obesity, and beta-oxidation defects. A second area of investigation centers on determining the function of PCSK9, a protein that is involved in determining plasma LDL cholesterol levels through its ability to post-transcriptionally regulate the expression of the LDL receptor in liver.

The Thinwa lab studies neurotropic viruses, host defense pathways, autophagy and brain development.

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The Cotter Research Group is a clinical lab focused on strategies to improve outcomes for patients with liver diseases with a particular focus on alcohol and metabolic dysfunction-associated liver diseases.