Leveraging cutting-edge genetic and chemical screens to uncover novel and enhanced therapeutics for cancer treatment.

In the Suleiman Lab, we focus on studying the podocyte biology, specifically the actin dynamics and cytoskeleton. Our research includes examining the balance of Rac and RhoA, two members of the Rho small GTPases, in both healthy and diseased kidneys. 

The Wang Lab investigates the roles of genetic factors and transcriptional regulation in skeletal diseases and bone cancer.

The Tatara Laboratory applies engineering technologies to study and treat infectious diseases. We are particularly engaged in device-related infection, orthopedic immunology, and pathogen virulence on biomaterial surfaces. 

The global focus of the Pulmonary Physiology Laboratory is the study of pulmonary exercise physiology, particularly as it pertains to pulmonary disease, normal aging, obesity, ventilatory control during exercise, applied respiratory physiology, and clinical cardiopulmonary exercise testing. The Lab consists of three separate investigative laboratories: the pulmonary function laboratory, the cardiopulmonary exercise physiology laboratory, and the body composition laboratory including DEXA imaging for the determination of percent body fat, lean body mass, bone content, visceral fat, overall fat distribution, and their effects on breathing.

The global focus of the Cardiovascular Physiology Autonomic Function Laboratory is to examine the adaptive capacity of the circulation.

• We study the effects of exercise training, bed rest deconditioning, spaceflight, high altitude, aging, and the effects of cardiovascular diseases, such as heart failure.
• By using sophisticated tools to assess cardiovascular structure and function, our research team brings "Olympic" and "space age" science to the solution of common clinical problems such as fainting, hypertension, or patients with shortness of breath. 
• We focus on measuring how the cardio-respiratory system distributes oxygen from the environment to the muscles.
• Our facility is one of the few labs in the world that can measure the limitations to exercise capacity at every step along the "oxygen cascade" - including the lungs, heart and muscles.
• We use invasive and non-invasive tools to assess cardiovascular structure and function, as well as circulatory control mechanisms.

Research in Dr. Crandall's Thermal and Vascular Physiology Laboratory focuses on neural control of the cardiovascular system and how different stressors influence that control in healthy, diseased, and injured individuals, such as:

• Identifying the consequences of severe burn injuries and subsequent skin grafting on the ability of the burn survivor to regulate internal temperature and cardiovascular function.
• Understanding the consequences of aging on cardiovascular stress during simulated heat waves.
• Exploring cooling modalities to attenuate thermal and cardiovascular stress.
• Understanding how analgesics used on the battlefield affect autonomic control of blood pressure during hemorrhage.

Our laboratory has a particular interest in hepatic metabolism and its regulation by the immune system. We utilize genetic, epigenetic and proteomic approaches, combined with detailed physiological studies, to understand the complex mechanisms that causally link inflammation to metabolic dysfunction in obesity and fatty liver disease.

The Ishii Laboratory is interested in understanding the bidirectional relationship between brain function and systemic metabolism with an emphasis on metabolic deficits in Alzheimer’s disease and how it differs from normal aging. Our laboratory focuses on generating hypotheses derived from open questions in clinical neurology and neuroendocrinology, testing these hypotheses using molecular genetics and neuroscience techniques in the laboratory, and whenever possible verifying these findings in clinically relevant human research studies. 

Preventing Cognitive Decline by Reducing Blood Pressure Target Trial (PCOT)
Researchers at UT Southwestern Medical Center are doing a study to prevent cognitive decline in adults by reducing blood pressure.