The Sharma Lab advances cardiovascular and transplant medicine through three integrated research areas:

1. Advanced metabolic imaging using hyperpolarized carbon-13 MRI and stable-isotope carbon-13 tracer methods to visualize cardiac metabolism in living tissue and patients.
2. Advanced multi-omics integrating transcriptomics and stable isotope-resolved metabolomics to map heart failure, ischemic heart disease, and donor organ biology while optimizing perfusion strategies for hearts and lungs.
3. Artificial intelligence and machine learning to develop explainable AI tools that support clinical decision-making in cardiothoracic surgery and transplantation.

The Welch Lab has a primary interest in developing materials and medical devices for use in treatment of congenital heart disease.