CDRC Initiatives

Mood Disorders Research

Driving Change Through Partnership

Continued advancements come through tireless pursuit, and our Center's faculty and staff understand that the commitment we renew each day is built upon a foundation of scholarship and a network of like-minded organizations. By sharing our findings worldwide, we strive to improve patient care and further the research momentum of our fellow scientists. Made possible by public grants and philanthropic investments, these programs provide civic and health partners with resources and tools to better prevent, identify, and treat depression in individuals of all ages.

Mood Disorders Research

Better Research. Better Care. Better Outcomes.

Existing research shows that mental illnesses are common in the United States, affecting tens of millions of people each year. Current estimates suggest that only half of people with mental illnesses receive treatment. Mental illnesses include many different conditions that vary in degree of severity, ranging from mild to moderate to severe type. 

52.9 million Adults suffer from mental illness in the U.S. [2020]
1 in 6 Adults in Texas experience mental health disorder in a given year [Substance Abuse and Mental Health Services Administration]
750,000 Texans have had suicidal thoughts in the last year [National Survey on Drug Use and Health]
61% Young adults (18-25) with mental illness receive no treatment
Mood Disorders Research

Our Statewide Initiatives

    Four Strategic Pillars

    A collaboration with Meadows Mental Health Policy Institute, The Cloudbreak Initiative focuses on standardizing early detection and treatment in primary care through two proven approaches: Measurement-Based Care (MBC), the routine use of repeated, validated measures to track symptoms and functional outcomes over time; and the Collaborative Care Model (CoCM), an integrated approach to the treatment of depression that involves care managers and consultant psychiatrists engaging directly within primary care settings.

    These pillars are:

    1. Effective Clinical Systems
    2. Research
    3. Smart Purchasing
    4. Public Engagement

    Best Care Research

    As a key leader in the field of mood disorders, Dr. Madhukar Trivedi serves as the Principal Investigator of the National Institute on Drug Abuse (NIDA) sponsored Clinical Trials Network (CTN) Big South/West Node that researches novel interventions aimed at improving outcomes for substance use disorders.

    Improving Access, Diagnosis, and Treatment

    The CDRC is participating in a collaboration with Meadows Mental Health Policy Institute, winner of the statewide Lone Star Depression Challenge, whose purpose is to scale an innovative, proven, transformative solution that builds healthier, stronger communities throughout Texas to improve the quality of life for all Texans.

    Depression Screening for Better Care

    The Texas Youth Depression and Suicide Research Network (TX-YDSRN) is a research initiative of the Texas Child Mental Health Care Consortium (TCMHCC), which was created by the 86th Texas Legislature. The TCMHCC funds multi-institutional research with potential for mental health care for children and adolescents in Texas. 

    Mental Health Promotion, Resilience & Suicide Prevention

    Youth Aware of Mental Health (YAM) is a universal mental health literacy and resilience program we are currently implementing in many schools in North Texas and our YAM team will begin state-wide implementation in the Fall of 2022 as a result of ARPA funding.

    Our Programs

      Mental Health Promotion & Resilience-Building

      Designed to prepare students for the Youth Aware of Mental Health (YAM) Program, Blue Steel is a trauma-informed, resilience-building education program designed to teach resilience skills and effective tools for supporting oneself and others during times of stress.

      Developing a Biosignature for Depression

      The Texas-Resilience Against Depression (T-RAD) program collects genetic, clinical, demographic, behavioral, and biological information from individuals at risk and those who have been diagnosed with depression or bipolar disorder. Through this 10-year program of 5,000 people, we hope to determine how best to treat and reduce the risk of mood disorders.

      Depression Screening & Better Care

      The TX-YDSRN hub is led by Dr. Madhukar Trivedi at UT Southwestern and co led by Dr. Sarah Wakefield at Texas Tech University Health Science Center. The purpose of this research network is to improve the evaluation of and response to the increasing problem of youth depression and suicide in Texas. This will be accomplished by evaluating the healthcare system in Texas as it relates to screening, responding, and monitoring youth symptoms indicative of depression and/or suicidal behaviors; and examining if the different ways in which youth depression presents in a primary care setting (e.g., sad v. irritable) might correlate with a best response with certain treatment (e.g., cognitive behavioral therapy v. supportive therapy).

      Making Screening for Depression the 6th Vital Sign

      VitalSign6 is an easy-to-use, comprehensive program for the identification and treatment of depression in primary care, pediatric, and specialty clinics.

      The program utilizes an innovative web-based application to administer the Patient Health Questionnaire (PHQ) and other Measurement-Based Care (MBC) systematic assessments to patients. Patients complete the measures on an iPad during the triage process, thus making screening for depression the sixth vital sign after body temperature, pulse rate, respiration rate, blood pressure, and pain.

      Mental Health Promotion, Resilience & Suicide Prevention

      Youth Aware of Mental Health, YAM, is an interactive program for adolescents promoting increased discussion and knowledge about mental health, suicide prevention, and the development of problem-solving skills and emotional intelligence. YAM brings different learning methods together with the fundamental components of the program being as follows: five interactive sessions, role-playing, informational reading materials and posters for display in the classroom.

      Focus on the Individual

      An important element of translating our research into practice involves creating access and capability to track mental health and wellness for the individual (adolescent and adult) within and beyond our community.

      Find out more
      support group meeting

      Focus on Systems

      To better understand the areas of greatest impact, we have identified and partnered with schools, community organizations, and healthcare systems on initiatives to improve the diagnosis and treatment of mood disorders and enhance suicide prevention efforts.

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      Drs. Andy Keller and Madhukar Trivedi

      Focus on Youth

      To better understand the areas of greatest impact, we have identified and partnered with schools, youth organizations, and healthcare systems on initiatives to improve the diagnosis and treatment of mood disorders and suicide prevention in youth.

      Find out more
      teacher presenting to students

      Real People. Real Research.

      Be part of the great impact we're having on science and medical care across the globe.

      The CDRC focuses on transforming the diagnosis and treatment of depression with a particular emphasis on developing an empirical basis for improving the treatment of depression. The center has been involved in many of the pivotal studies involving the establishment of the efficacy of antidepressant treatments (medications, psychotherapy, exercise, complementary treatments, devices, etc.), examining next steps in treatment-resistant depression to develop algorithms and guidelines, and developing and validating biomarkers to reach the goal of precision medicine for mood disorders.