Texas-Resilience Against Depression Program

Mood Disorders Research

Developing a Biosignature for Depression

The Texas-Resilience Against Depression (T-RAD) program collects genetic, clinical, demographic, behavioral, and biological information from individuals at risk and those who have been diagnosed with depression or bipolar disorder. Through this 10-year program of 5,000 people, we hope to determine how best to treat and reduce the risk of mood disorders.

Not all depressed patients respond well to the same treatments, so it’s important to identify the right treatment for the right patient as quickly as possible. To replace the current “trial and error method” of treating depression, we hope to identify biosignatures – a collection of genetic, clinical, demographic, behavioral, and biological markers to determine which treatment methods might be best for individual patients.

Mood Disorders Research

Real People, Real Research

Major depression will affect 1 in 20 individuals in the United States this year and is the leading cause of disability worldwide. Increased depression severity is associated with poorer work productivity, functioning, general health, quality of life, life satisfaction, and well-being. To date, there are no effective biological methods to diagnose and assess depression or treatment response.

    Dallas 2K Study

    The D2K study is a long-term study researching the biological mechanisms of depression and antidepressant treatment response. The D2K study is comprised of 2,000 participants, over 10 years of age, with a lifetime or current diagnosis of a mood disorder. Researchers will collect socio-demographic and clinical data, cognitive and psychological assessments, fluid-based biomarkers (blood, urine, saliva), neuroimaging, and EEG. With this information, we hope to create a biosignature to aid in treatment selection and to identify a universal test for depression.

    If you would like to participate in this study, complete our form.

    Resilience in Adolescent Development Study

    Resilience in Adolescent Development (RAD) is a 10-year study of 1,500 participants (ages 10-24) that will help uncover the factors that contribute to resilience among children, adolescents, and young adults at risk for mood and anxiety disorders.

    If you would like to participate in this study, complete our form.

    Building Resilience in Youth

    Designed to prepare students for the Youth Aware of Mental Health (YAM) Program, Blue Steel is a trauma-informed, resilience-building education program designed to teach resilience skills and effective tools for supporting one's self and others during times of stress.

    Find out more
    support group meeting

    Collaborating Across Texas

    The TX-YDSRN hub is led by Dr. Madhukar Trivedi at UT Southwestern and co led by Dr. Sarah Wakefield at Texas Tech University Health Science Center. The purpose of this research network is to improve the evaluation of and response to the increasing problem of youth depression and suicide in Texas.

    Find out more
    image of the state of Texas with nodes

    Measuring for Better Treatment

    Measurement-based care is an important aspect of our work and focuses on making depression the 6th vital sign physicians monitor during primary care visits. The VitalSign6 program is one of the CDRC's longest running programs, and their goal is to make incorporating measurement-based care into primary care and pediatric clinics easy for clinicians.

    Find out more
    VitalSign6 Texas Tech rollout

    Solving Depression, Saving Tomorrows

    Be part of the great impact we're having on science and medical care across the globe.

    Programs available through the Risk and Resilience Network will allow adolescents to learn and develop life-long coping and resilience skills that are shown to help teens and young adults avoid high risk and self-destructive behavior that can lead to poor academic achievement, substance abuse, more severe psychiatric conditions, and even suicide.