Feb 2024
Congratulations to graduate student Devon Jeltema for winning the Kirkpatrick Award!
Jeltema Kirkpatrick Award
April 2023
Congratulations to graduate student Zhen Tang and Cong Xing for passing Qualifying Exam!
June 2022
Science Immunology Cover Story on our RNA Exosome paper
We found that the SKIV2L RNA exosome is essential for V(D)J recombination and the pro–B cell to large pre–B cell transition during early B cell development.
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May 2022
Dr. Xintao Tu Graduation!
September 2021
Researchers find immune component to rare neurodegenerative disease
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August 2020
Finding a way to STING tumor growth
UTSW reports on our recent Immunity paper.
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September 2018
Dr. Vlad Pokatayev Graduation!
May 2018
Dr. Charles Fermaintt Graduation!
March 2017
Tomomi Sakai publishes in Autoimmunity
Sakai T, Miyazaki T, Shin DM, Kim YS, Qi CF, Fariss R, Munasinghe J, Wang H, Kovalchuk AL, Kothari PH, Fermaintt CS, Atkinson JP, Perrino FW, Yan N, Morse HC 3rd. Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism. J Autoimmun. 2017 Mar 18. pii: S0896-8411(17)30024-0. doi: 10.1016/j.jaut.2017.03.001. [Epub ahead of print]
Read the Full PublicationMarch 2017
Martin and Charles’s paper on TREX1 mitotic phosphorylation is published in Cell Reports
Kucej M, Fermaintt CS, Yang K, Irizarry-Caro RA, Yan N. Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex . Cell Rep. 2017 Mar 14;18(11):2600-2607. doi: 10.1016/j.celrep.2017.02.051.
Read the Full PublicationJanuary 2017
Maroof and Vijay’s paper on mTORC1 published in PNAS
Hasan M, Gonugunta VK, Dobbs N, Ali A, Palchik G, Calvaruso MA, DeBerardinis RJ, Yan N. Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism. PNAS USA. 2017 Jan 24;114(4):746-751. doi: 10.1073/pnas.1611113114. Epub 2017 Jan 9.
Read the Full PublicationMarch 2016
Vlad Pokatayev publishes in Journal of Experimental Medicine
Pokatayev V, Hasin N, Chon H, Cerritelli SM, Sakhuja K, Ward JM, Morris HD, Yan N, Crouch RJ. RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice . J Exp Med. 2016 Mar 7; 213(3):329-36. doi: 10.1084/jem.20151464. Epub 2016 Feb 15.
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RNase H2 Regulates cGAS-STING
RNase H2 acts to prevent activation of the cGAS-STING DNA-sensing pathway.
Read the Full PublicationNovember 2015
Maroof Hasan publishes in J Immunology
Hasan M, Dobbs N, Khan S, White MA, Wakeland EK, Li QZ, Yan N. Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice. J Immunol. 2015 Nov 15;195(10):4573-7. doi: 10.4049/jimmunol.1500162. Epub 2015 Oct 2.
Read the Full PublicationAugust 2015
Maroof Hasan and Charles Fermaintt have a paper published in Immunity
Hasan M, Fermaintt CS, Gao N, Sakai T<, Miyazaki T, Jiang S, Li QZ,, Atkinson JP, Morse HC 3rd, Lehrman MA, Yan N.Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.Immunity. 2015 Sep 15;43(3):463-74. doi: 10.1016/j.immuni.2015.07.022. Epub 2015 Aug 25.
Read the Full PublicationAugust 2015
Nicole Dobb’s research on STING published in Cell Host & Microbes
Dobbs N, Burnaevskiy N,, Chen D, Gonugunta VK, Alto NM, Yan N. STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease, Cell Host Microbe. 2015 Aug 12;18(2):157-68. doi: 10.1016/j.chom.2015.07.001. Epub 2015 Jul 30.
Read the Full PublicationMay 2013
Charles Fermaintt Receives NSF Grant
Congratulations, Charles!
December 2012
Maroof’s paper on TREX1 is published in Nature Immunology
Hasan M, Koch J, Rakheja D, Pattnaik AK, Brugarolas J, Dozmorov I, Levine B, Wakeland EK, Lee-Kirsch MA, Yan N. Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes. Nat Immunol. 2013 Jan;14(1):61-71. doi: 10.1038/ni.2475.
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