Publications

RNA helicase SKIV2L limits antiviral defense and autoinflammation elicited by the OAS-RNase L pathway.

Systemic gene therapy corrects neurological phenotype in a mouse model of NGLY1 deficiency.

Innate immune sensing of macromolecule homeostasis.

STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges.

Bilayer STING goes head to head to stay put.

STING trafficking as a new dimension of immune signaling.

Interruption of post-Golgi STING trafficking activates tonic interferon signaling.

The mammalian SKIV2L RNA exosome is essential for early B cell development.

Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease.

No Longer A One-Trick Pony: STING Signaling Activity Beyond Interferon.

Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.

Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion.

Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.

Reactive oxygen species oxidize STING and suppress interferon production.

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response.

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death.

Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis.

N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1.

Co-circulation dynamics and persistence of newly introduced clades of 2012 outbreak associated West Nile Virus in Texas, 2012-2015.

STING-associated vasculopathy develops independently of IRF3 in mice.

Innate Immune Activation by cGMP-AMP Nanoparticles Leads to Potent and Long-Acting Antiretroviral Response against HIV-1.

Immune Diseases Associated with TREX1 and STING Dysfunction.

Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex.

DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism.

Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response.

Methods of Assessing STING Activation and Trafficking.

RNase H2 catalytic core Aicardi-Goutieres syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.

Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice.

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.

STING activation by translocation from the ER is associated with infection and autoinflammatory disease.

Safeguard against DNA sensing: the role of TREX1 in HIV-1 infection and autoimmune diseases.

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.

Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses.

SAMHD1 does it again, now in resting T cells.

Intrinsic antiviral immunity.

HIV DNA is heavily uracilated, which protects it from autointegration.

Gaining a foothold: how HIV avoids innate immune recognition.

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1.

The SET complex acts as a barrier to autointegration of HIV-1.

Identification of host proteins required for HIV infection through a functional genomic screen.