Publications

Cellular senescence and lung cancer prognosis

Asaithamby A, Shay JW, Minna JD 2022 Oct 11 1982-1987

NBS1-CtIP-mediated DNA end resection suppresses cGAS binding to micronuclei

Abdisalaam S, Mukherjee S, Bhattacharya S, Kumari S, Sinha D, Ortega Rodriguez J, Li G, Sadek HA, Krishnan S, Asaithamby A 2022 Mar 50 2681-2699

Mitochondrial fatty acid utilization increases chromatin oxidative stress in cardiomyocytes

Menendez-Montes I, Abdisalaam S, Xiao F, Lam NT, Mukherjee S, Szweda LI, Asaithamby A, Sadek HA 2021 Aug 118

Immunomodulatory effects of radiotherapy

Kumari S, Mukherjee S, Sinha D, Abdisalaam S, Krishnan S, Asaithamby A 2020 Nov 21 1-29

Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

Abdisalaam S, Bhattacharya S, Mukherjee S, Sinha D, Srinivasan K, Zhu M, Akbay EA, Sadek HA, Shay JW, Asaithamby A 2020 Aug 295 11144-11160

Pancreatic cancer patients with germline BRCA mutations can benefit from olaparib treatment

Mukherjee S, Asaithamby A 2020 Apr 9 2154-2156

Tumor treating fields cause replication stress and interfere with DNA replication fork maintenance: Implications for cancer therapy

Karanam NK, Ding L, Aroumougame A, Story MD 2020 Mar 217 33-46

Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression

Cardoso AC, Lam NT, Savla JJ, Nakada Y, Pereira AH, Elnwasany A, Menendez-Montes I, Ensley EL, Bezan Petric U, Sharma G, Sherry AD, Malloy CR, Khemtong C, Kinter MT, Tan WL, Anene-Nzelu CG, Foo RS, Nguyen NU, Li S, Ahmed MS, Elhelaly WM, Abdisalaam S, Asaithamby A, Xing C, Kanchwala M, Vale G, Eckert KM, Mitsche MA, McDonald JG, Hill JA, Huang L, Shaul PW, Szweda LI, Sadek HA 2020 Feb 2 167-178

Isolation of time-dependent DNA damage induced by energetic carbon ions and their fragments using fluorescent nuclear track detectors

McFadden CH, Rahmanian S, Flint DB, Bright SJ, Yoon DS, O’Brien DJ, Asaithamby A, Abdollahi A, Greilich S, Sawakuchi GO 2020 Jan 47 272-281

Nonhomologous End Joining Is More Important Than Proton Linear Energy Transfer in Dictating Cell Death

Bright SJ, Flint DB, Chakraborty S, McFadden CH, Yoon DS, Bronk L, Titt U, Mohan R, Grosshans DR, Sumazin P, Shaitelman SF, Asaithamby A, Sawakuchi GO 2019 Dec 105 1119-1125

DNA Damage Response Mediates Pressure Overload-Induced Cardiomyocyte Hypertrophy

Nakada Y, Nhi Nguyen NU, Xiao F, Savla JJ, Lam NT, Abdisalaam S, Bhattacharya S, Mukherjee S, Asaithamby A, Gillette TG, Hill JA, Sadek HA 2019 Feb 139 1237-1239

Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling

Mukherjee S, Abdisalaam S, Bhattacharya S, Srinivasan K, Sinha D, Asaithamby A 2019 Jan 297-324

Nuclear foci assays in live cells

Mori E, Asaithamby A 2019 75-85

Dynamin impacts homology-directed repair and breast cancer response to chemotherapy

Chernikova SB, Nguyen RB, Truong JT, Mello SS, Stafford JH, Hay MP, Olson A, Solow-Cordero DE, Wood DJ, Henry S, von Eyben R, Deng L, Gephart MH, Aroumougame A, Wiese C, Game JC, Győrffy B, Martin Brown J 2018 Dec 128 5307-5321

Werner syndrome protein and dna replication

Mukherjee S, Sinha D, Bhattacharya S, Srinivasan K, Abdisalaam S, Aroumougame A 2018 Nov 19

Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy

Bhattacharya S, Asaithamby A 2017 Jul 6 S822-S839

RAD51 interconnects between DNA replication, DNA repair and immunity

Bhattacharya S, Srinivasan K, Abdisalaam S, Su F, Raj P, Dozmorov I, Mishra R, Wakeland EK, Ghose S, Mukherjee S, Asaithamby A 2017 May 45 4590-4605

Hypoxia induces heart regeneration in adult mice

Nakada Y, Canseco DC, Thet S, Abdisalaam S, Aroumougame A, Santos CX, Shah AM, Zhang H, Faber JE, Kinter MT, Szweda LI, Xing C, Hu Z, DeBerardinis RJ, Schiattarella G, Hill JA, Oz OK, Lu Z, Zhang C, Kimura W, Sadek HA 2017 Jan 541 222-227

Tumor suppressor protein DAB2IP participates in chromosomal stability maintenance through activating spindle assembly checkpoint and stabilizing kinetochore-microtubule attachments

Yu L, Shang ZF, Abdisalaam S, Lee KJ, Gupta A, Hsieh JT, Asaithamby A, Chen BP, Saha D 2016 Oct 44 8842-8854

Ionizing radiation and heart risks

Bhattacharya S, Asaithamby A 2016 Oct 58 14-25

Time-Lapse Monitoring of DNA Damage Colocalized With Particle Tracks in Single Living Cells

McFadden CH, Hallacy TM, Flint DB, Granville DA, Asaithamby A, Sahoo N, Akselrod MS, Sawakuchi GO 2016 Sep 96 221-227

COMT val158met polymorphism and molecular alterations in the human dorsolateral prefrontal cortex: Differences in controls and in schizophrenia

Shukla AA, Jha M, Birchfield T, Mukherjee S, Gleason K, Abdisalaam S, Asaithamby A, Adams-Huet B, Tamminga CA, Ghose S 2016 May 173 94-100

Erratum: Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart (Nature (2015) 523 (226-230) DOI: 10.1038/nature14582)

Kimura W, Xiao F, Canseco DC, Muralidhar S, Thet S, Zhang HM, Abderrahman Y, Chen R, Garcia JA, Shelton JM, Richardson JA, Ashour AM, Aroumougame A, Liang H, Xing C, Lu Z, Zhang C, Sadek HA 2016 Apr 532 268

Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway

Su F, Bhattacharya S, Abdisalaam S, Mukherjee S, Yajima H, Yang Y, Mishra R, Srinivasan K, Ghose S, Chen DJ, Yannone SM, Asaithamby A 2016 7 46-65

Evaluating biomarkers to model cancer risk post cosmic ray exposure

Sridharan DM, Asaithamby A, Blattnig SR, Costes SV, Doetsch PW, Dynan WS, Hahnfeldt P, Hlatky L, Kidane Y, Kronenberg A, Naidu MD, Peterson LE, Plante I, Ponomarev AL, Saha J, Snijders AM, Srinivasan K, Tang J, Werner E, Pluth JM 2016 9 19-47

Transcriptional elongation requires DNA break-induced signalling

Bunch H, Lawney BP, Lin YF, Asaithamby A, Murshid A, Wang YE, Chen BP, Calderwood SK 2015 Dec 6

Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart

Kimura W, Xiao F, Canseco DC, Muralidhar S, Thet S, Zhang HM, Abderrahman Y, Chen R, Garcia JA, Shelton JM, Richardson JA, Ashour AM, Aroumougame A, Liang H, Xing C, Lu Z, Zhang C, Sadek HA 2015 Jul 523 226-230

Human ventricular unloading induces cardiomyocyte proliferation

Canseco DC, Kimura W, Garg S, Mukherjee S, Bhattacharya S, Abdisalaam S, Das S, Asaithamby A, Mammen PP, Sadek HA 2015 Mar 65 892-900

The major DNA repair pathway after both proton and carbon-ion radiation is NHEJ, but the HR pathway is more relevant in carbon ions

Gerelchuluun A, Manabe E, Ishikawa T, Sun L, Itoh K, Sakae T, Suzuki K, Hirayama R, Asaithamby A, Chen DJ, Tsuboi K 2015 Mar 183 345-356

Understanding Cancer Development Processes after HZE-Particle Exposure: Roles of ROS, DNA Damage Repair and Inflammation

Sridharan DM, Asaithamby A, Bailey SM, Costes SV, Doetsch PW, Dynan WS, Kronenberg A, Rithidech KN, Saha J, Snijders AM, Werner E, Wiese C, Cucinotta FA, Pluth JM 2015 Jan 183 1-26

FANCD2 influences replication fork processes and genome stability in response to clustered DSBs

Zhu J, Su F, Mukherjee S, Mori E, Hu B, Asaithamby A 2015 Jan 14 1809-1822

PTIP associates with artemis to dictate DNA repair pathway choice

Wang J, Aroumougame A, Lobrich M, Li Y, Chen D, Chenj J, Gong Z 2014 Dec 28 2693-2698

Nonenzymatic Role for WRN in Preserving Nascent DNA Strands after Replication Stress

Su F, Mukherjee S, Yang Y, Mori E, Bhattacharya S, Kobayashi J, Yannone SM, Chen DJ, Asaithamby A 2014 Nov 9 1387-1401

MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice

Gupta A, Hunt CR, Hegde ML, Chakraborty S, Udayakumar D, Horikoshi N, Singh M, Ramnarain DB, Hittelman WN, Namjoshi S, Asaithamby A, Hazra TK, Ludwig T, Pandita RK, Tyler JK, Pandita TK 2014 Jul 8 319

MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice

Gupta A, Hunt CR, Hegde ML, Chakraborty S, Udayakumar D, Horikoshi N, Singh M, Ramnarain DB, Hittelman WN, Namjoshi S, Asaithamby A, Hazra TK, Ludwig T, Pandita RK, Tyler JK, Pandita TK 2014 Jul 8 177-189

Erratum: The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response (Cell (2014) 157 (741-743))

Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Asaithamby A, Shah AM, Szweda LI, Sadek HA 2014 May 157 1243

The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response

Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA 2014 Apr 157 565-579

Proximity within interphase chromosome contributes to the breakpoint distribution in radiation-induced intrachromosomal exchanges

Zhang Y, Uhlemeyer J, Hada M, Asaithamby A, Chen DJ, Wu H 2014 2 23-28

New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

Chen BP, Li M, Asaithamby A 2012 Dec 327 103-110

Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells

Neumaier T, Swenson J, Pham C, Polyzos A, Lo AT, Yang P, Dyball J, Asaithamby A, Chen DJ, Bissell MJ, Thalhammer S, Costes SV 2012 Jan 109 443-448

Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture

Asaithamby A, Hu B, Delgado O, Ding LH, Story MD, Minna JD, Shay JW, Chen DJ 2011 Jul 39 5474-5488

Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation

Asaithamby A, Chen DJ 2011 Jun 711 87-99

Unrepaired clustered DNA lesions induce chromosome breakage in human cells

Asaithamby A, Hu B, Chen DJ 2011 May 108 8293-8298

Knockdown of clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior

Mukherjee S, Coque L, Cao JL, Kumar J, Chakravarty S, Asaithamby A, Graham A, Gordon E, Enwright JF, Dileone RJ, Birnbaum SG, Cooper DC, McClung CA 2010 Sep 68 503-511

Identification of a coiled coil in Werner syndrome protein that facilitates multimerization and promotes exonuclease processivity

Perry JJ, Asaithamby A, Barnebey A, Kiamanesch F, Chen DJ, Han S, Tainer JA, Yannone SM 2010 Aug 285 25699-25707

WRN participates in translesion synthesis pathway through interaction with NBS1

Kobayashi J, Okui M, Asaithamby A, Burma S, Chen BP, Tanimoto K, Matsuura S, Komatsu K, Chen DJ 2010 Jun 131 436-444

Overexpression of progesterone receptor A isoform in mice leads to endometrial hyperproliferation, hyperplasia and atypia

Fleisch MC, Chou YC, Cardiff RD, Asaithambi A, Shyamala G 2009 15 241-249

Cellular responses to DNA double-strand breaks after low-dose γ-irradiation

Asaithamby A, Chen DJ 2009 37 3912-3923

Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts

Asaithamby A, Uematsu N, Chatterjee A, Story MD, Burma S, Chen DJ 2008 Apr 169 437-446

RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR

Ramnarain DB, Paulmurugan R, Park S, Mickey BE, Asaithamby A, Saha D, Kelliher MA, Mukhopadhyay P, Banani F, Madden CJ, Wright PS, Chakravarty S, Habib AA 2008 Feb 15 344-353

Ku recruits XLF to DNA double-strand breaks

Yano KI, Morotomi-Yano K, Wang SY, Uematsu N, Lee KJ, Asaithamby A, Weterings E, Chen DJ 2008 Jan 9 91-96

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

Perry JJ, Yannone SM, Holden LG, Hitomi C, Asaithamby A, Han S, Cooper PK, Chen DJ, Tainer JA 2006 May 13 414-422

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks

Chen BP, Chan DW, Kobayashi J, Burma S, Asaithamby A, Morotomi-Yano K, Botvinick E, Qin J, Chen DJ 2005 Apr 280 14709-14715

MDC1 regulates DNA-PK autophosphorylation in response to DNA damage

Lou Z, Chen BP, Asaithamby A, Minter-Dykhouse K, Chen DJ, Chen J 2004 Nov 279 46359-46362

Progesterone receptor expression in medroxyprogesterone acetate-induced murine mammary carcinomas and response to endocrine treatment

Helguero LA, Viegas M, Asaithamby A, Shyamala G, Lanari C, Molinolo AA 2003 Jun 79 379-390

Synthesis and phosphorylation of androgen receptor of the mouse brain cortex and their regulation by sex steroids during aging

Thakur MK, Asaithambi A, Mukherjee S 2000 Mar 203 95-101

Amplification of exons 4 and 5 of Androgen Receptor gene by testosterone in aged female mouse brain cortex

Thakur MK, Asaithambi A, Mukherjee S 2000 1 329-334

Sex-specific alterations in chromatin conformation of the brain of aging mouse

Thakur MK, Asaithambi A, Mukherjee S 1999 Dec 26 239-247

Sex steroids modulate the synthesis and phosphorylation of proteins in the brain cortex of aging mice

Mukherjee S, Asaithambi A, Thakur MK 1999 Nov 111 13-22

Age-dependent degradation of amyloid precursor protein in the post-mortem mouse brain cortex

Asaithambi A, Mukherjee S, Thakur MK 1999 Aug 26 179-184

Expression of 112-kDa estrogen receptor in mouse brain cortex and its autoregulation with age

Asaithambi A, Mukherjee S, Thakur MK 1997 Feb 231 683-685

Androgen treatment protects mouse liver chromatin from cleavage by endogenous nucleases during aging: Androgen and nuclease activity

Mukherjee S, Asaithambi A, Thakur MK 1995 Feb 22 59-61