Singla A, Fedoseienko A, Giridharan SSP, Overlee BL, Lopez A, Jia D, Song J, Huff-Hardy K, Weisman L, Burstein E, Billadeau DD,
2019 Sep
Nat Commun
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Sifuentes-Dominguez LF, Li H, Llano E, Liu Z, Singla A, Patel AS, Kathania M, Khoury A, Norris N, Rios JJ, Starokadomskyy P, Park JY, Gopal P, Liu Q, Tan S, Chan L, Ross T, Harrison S, Venuprasad K, Baker LA, Jia D, Burstein E,
2019 Oct
Elife
8
Miyata N, Morris LL, Chen Q, Thorne C, Singla A, Zhu W, Winter M, Melton SD, Li H, Sifuentes-Dominguez L, Llano E, Huff-Hardy K, Starokadomskyy P, Lopez A, Reese TA, Turer E, Billadeau DD, Winter SE, Burstein E
2018 Aug
Cell Rep
9
24
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Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.
McNally KE, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, Langton P, Pearson N, Danson CM, Nägele H, Morris LL, Singla A, Overlee BL, Heesom KJ, Sessions R, Banks L, Collins BM, Berger I, Billadeau DD, Burstein E, Cullen PJ 2017 Oct Nat. Cell Biol. 10 19 1214-1225DNA polymerase-a regulates the activation of type I interferons through cytosolic RNA:DNA synthesis.
Starokadomskyy P, Gemelli T, Rios JJ, Xing C, Wang RC, Li H, Pokatayev V, Dozmorov I, Khan S, Miyata N, Fraile G, Raj P, Xu Z, Xu Z, Ma L, Lin Z, Wang H, Yang Y, Ben-Amitai D, Orenstein N, Mussaffi H, Baselga E, Tadini G, Grunebaum E, Sarajlija A, Krzewski K, Wakeland EK, Yan N, de la Morena MT, Zinn AR, Burstein E 2016 Mar Nat. Immunol.Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.
Li H, Koo Y, Mao X, Sifuentes-Dominguez L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen JM, Vooijs M, Billadeau DD, van de Sluis B, Cleaver O, Burstein E 2015 Nov J. Cell Biol. 3 211 605-17
Phillips-Krawczak CA, Singla A, Starokadomskyy P, Deng Z, Osborne DG, Li H, Dick CJ, Gomez TS, Koenecke M, Zhang JS, Dai H, Sifuentes-Dominguez LF, Geng LN, Kaufmann SH, Hein MY, Wallis M, McGaughran J, Gecz J, van de Sluis B, Billadeau DD, Burstein E
2014 Oct
Mol. Biol. Cell
Maine GN, Mao X, Komarck CM, Burstein E
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EMBO J.
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COMMD proteins, a novel family of structural and functional homologs of MURR1.
Burstein E, Hoberg JE, Wilkinson AS, Rumble JM, Csomos RA, Komarck CM, Maine GN, Wilkinson JC, Mayo MW, Duckett CS 2005 Jun J. Biol. Chem. 23 280 22222-32CCDC22 mutations that impair COMMD binding cause attenuated 3C/Ritscher-Schinzel syndrome.
Singla A, Rogers C, Touma MJ, El-Najjar Y, Colley A, Boesch DJ, Billadeau DD, Gecz J, Chen B, Burstein E, 2025 May BMC Med Genomics 1 18 98
Chen B, Burstein E, Billadeau DD,
2025 Aug
Proc Natl Acad Sci U S A
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Structural basis for Retriever-SNX17 assembly and endosomal sorting.
Singla A, Boesch DJ, Fung HYJ, Ngoka C, Enriquez AS, Song R, Kramer DA, Han Y, Banarer E, Lemoff A, Juneja P, Billadeau DD, Bai X, Chen Z, Turer EE, Burstein E, Chen B, 2024 Nov Nat Commun 1 15 10193Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism.
Tan S, Santolaya JL, Wright TF, Liu Q, Fujikawa T, Chi S, Bergstrom CP, Lopez A, Chen Q, Vale G, McDonald JG, Schmidt A, Vo N, Kim J, Baniasadi H, Li L, Zhu G, He TC, Zhan X, Obata Y, Jin A, Jia D, Elmquist JK, Sifuentes-Dominguez L, Burstein E, 2024 May Nat MetabStructural organization of the retriever-CCC endosomal recycling complex.
Boesch DJ, Singla A, Han Y, Kramer DA, Liu Q, Suzuki K, Juneja P, Zhao X, Long X, Medlyn MJ, Billadeau DD, Chen Z, Chen B, Burstein E, 2023 Dec Nat Struct Mol Biol
Giridharan SSP, Luo G, Rivero-Rios P, Steinfeld N, Tronchere H, Singla A, Burstein E, Billadeau DD, Sutton MA, Weisman LS,
2022 Jan
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Paneth cell-derived growth factors support tumorigenesis in the small intestine.
Chen Q, Suzuki K, Sifuentes-Dominguez L, Miyata N, Song J, Lopez A, Starokadomskyy P, Gopal P, Dozmorov I, Tan S, Ge B, Burstein E, 2021 Mar Life Sci Alliance 3 4
Kumar R, Singh AK, Starokadomskyy P, Luo W, Theiss AL, Burstein E, Venuprasad K,
2021 Jan
J Immunol
Immune Dysfunction in Mendelian Disorders of POLA1 Deficiency.
Starokadomskyy P, Escala Perez-Reyes A, Burstein E, 2021 Jan J Clin ImmunolStructural and mechanistic insights into secretagogin-mediated exocytosis.
Qin J, Liu Q, Liu Z, Pan YZ, Sifuentes-Dominguez L, Stepien KP, Wang Y, Tu Y, Tan S, Wang Y, Sun Q, Mo X, Rizo J, Burstein E, Jia D, 2020 Mar Proc. Natl. Acad. Sci. U.S.A. 12 117 6559-6570Regulation of copper homeostasis by members of the COMMD protein family.
Singla A, Chen Q, Suzuki K, Song J, Fedoseienko A, Wijers M, Lopez A, Billadeau DD, van de Sluis B, Burstein E, 2020 Dec Dis Model Mech
Starokadomskyy P, Wilton KM, Krzewski K, Lopez A, Sifuentes-Dominguez L, Overlee B, Chen Q, Ray A, Gil-Krzewska A, Peterson M, Kinch LN, Rohena L, Grunebaum E, Zinn AR, Grishin NV, Billadeau DD, Burstein E,
2019 Nov
JCI Insight
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4
Zhu W, Miyata N, Winter MG, Arenales A, Hughes ER, Spiga L, Kim J, Sifuentes-Dominguez L, Starokadomskyy P, Gopal P, Byndloss MX, Santos RL, Burstein E, Winter SE,
2019 Jul
J. Exp. Med.
Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E
2014 Apr
Gastroenterology
CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling.
Starokadomskyy P, Gluck N, Li H, Chen B, Wallis M, Maine GN, Mao X, Zaidi IW, Hein MY, McDonald FJ, Lenzner S, Zecha A, Ropers HH, Kuss AW, McGaughran J, Gecz J, Burstein E 2013 Apr J. Clin. Invest.Regulation of NF-?B activity by competition between RelA acetylation and ubiquitination.
Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine GN, Kracht M, Schmitz ML, Burstein E 2011 Jun OncogeneCOMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion.
van de Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, van der Wall E, van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E 2010 Jun J. Clin. Invest. 6 120 2119-30GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA.
Mao X, Gluck N, Li D, Maine GN, Li H, Zaidi IW, Repaka A, Mayo MW, Burstein E 2009 Apr Genes Dev. 7 23 849-61
Mufti AR, Burstein E, Csomos RA, Graf PC, Wilkinson JC, Dick RD, Challa M, Son JK, Bratton SB, Su GL, Brewer GJ, Jakob U, Duckett CS
2006 Mar
Mol. Cell
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A novel role for XIAP in copper homeostasis through regulation of MURR1.
Burstein E, Ganesh L, Dick RD, van De Sluis B, Wilkinson JC, Klomp LW, Wijmenga C, Brewer GJ, Nabel GJ, Duckett CS 2004 Jan EMBO J. 1 23 244-54The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes.
Ganesh L, Burstein E, Guha-Niyogi A, Louder MK, Mascola JR, Klomp LW, Wijmenga C, Duckett CS, Nabel GJ 2003 Dec Nature 6968 426 853-7Join Our Lab
There are frequent opportunities to join our lab. If you have an interest in the research that we are conducting and would like to be considered for a position in the lab, please send an email including your CV and a letter of interest to Ezra Burstein.