TET2-Mutant Clonal Hematopoiesis Promotes Heart Failure With Preserved Ejection Fraction.
Pandey A, Thomas T, Ji Y, Kroger B, Carlsgaard P, Irion CI, Kalkan F, Segar M, Subramanian V, Bayés-Genís A, Son A, Young KA, Trowbridge JJ, Premnath N, Jiang N, Daou D, Hu W, Ware SA, Tong D, Chung SS, 2025 Jun Circulation 22 151 1622-1625
Nishino J, Hu W, Kishtagari A, Shen B, Gao X, Blackman CM, Kassim A, Marneni N, Cherukuri AV, Vittrup R, Kalkan FN, Shah R, Ahn C, Gao A, Ahmedrabie A, Collins RH, Zeidan AM, Bidikian A, Gowda L, Shaffer BC, Madanat YF, Zhao Z, Chung SS, Morrison SJ
2024
Cancer Discov
CD99 is a therapeutic target on disease stem cells in myeloid malignancies.
Chung SS, Eng WS, Hu W, Khalaj M, Garrett-Bakelman FE, Tavakkoli M, Levine RL, Carroll M, Klimek VM, Melnick AM, Park CY 2017 01 Sci Transl Med 374 9Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia.
Chung SS, Kim E, Park JH, Chung YR, Lito P, Teruya-Feldstein J, Hu W, Beguelin W, Monette S, Duy C, Rampal R, Telis L, Patel M, Kim MK, Huberman K, Bouvier N, Berger MF, Melnick AM, Rosen N, Tallman MS, Park CY, Abdel-Wahab O 2014 May Sci Transl Med 238 6 238ra71
Kometas ML, Hoff FW, Hyak J, Irizarry-Gatell V, Marinos Velarde A, Jackson C, Anderson J, Kalkan FN, Ramakrishnan Geethakumari P, Alvarenga Thiebaud J, Chen W, Weinberg OK, Cantu MD, Collins RH, Chung SS, Madanat YF,
2025 Mar
Leuk Lymphoma
1-9
CD44-Mediated Metabolic Rewiring is A Targetable Dependency of IDH-Mutant Leukemia.
Lyu J, Liu Y, Liu N, Vu H, Cai F, Cao H, Kaphle P, Wu Z, Botten GA, Zhang Y, Wang J, Achyutuni S, Gao X, Iacobucci I, Mullighan CG, Chung SS, Ni M, DeBerardinis RJ, Xu J, 2025 Jan BloodRAS-mutant leukaemia stem cells drive clinical resistance to venetoclax.
Sango J, Carcamo S, Sirenko M, Maiti A, Mansour H, Ulukaya G, Tomalin LE, Cruz-Rodriguez N, Wang T, Olszewska M, Olivier E, Jaud M, Nadorp B, Kroger B, Hu F, Silverman L, Chung SS, Wagenblast E, Chaligne R, Eisfeld AK, Demircioglu D, Landau DA, Lito P, Papaemmanuil E, DiNardo CD, Hasson D, Konopleva M, Papapetrou EP, 2024 Oct Nature
Premnath N, Liu Y, Reves H, Pandey U, Nair RG, Anderson J, Afrough A, Anderson LD, Chung SS, Kaur G, Khan AM, Kumar KA, Madanat YF, Wolfe HR, Yilmaz E, Awan FT, Sweetenham J, Ramakrishnan Geethakumari P,
2024 Oct
JCO Oncol Pract
OP2400354
Risk Prediction for Clonal Cytopenia: Multicenter Real-World Evidence.
Xie Z, Komrokji RS, Al-Ali N, Regelson A, Geyer S, Patel AA, Saygin C, Zeidan AM, Bewersdorf JP, Mendez LM, Kishtagari A, Zeidner JF, Coombs CC, Madanat YF, Chung SS, Badar T, Foran JM, Desai P, Tsai C, Griffiths EA, Al Malki MM, Amanam I, Lai C, Deeg HJ, Ades L, Arana-Yi C, Osman AE, Dinner SN, Abaza Y, Taylor J, Chandhok NS, Soong D, Brunner AM, Carraway HE, Singh A, Elena C, Ferrari J, Galli A, Pozzi S, Padron E, Patnaik MM, Malcovati L, Savona MR, Al-Kali A, 2024 Jul Blood
Dong S, Premnath N, Sadeghi N, Kainthla R, Chung SS, Collins RH, Li HC, Madanat YF,
2024 Apr
Leuk Res
141
107503
Li Y, Hook JS, Ding Q, Xiao X, Chung SS, Mettlen M, Xu L, Moreland JG, Agathocleous M,
2023 May
Nat Commun
1
14
2610
Premnath N, Chung SS, Weinberg OK, Ikpefan R, Pandey M, Kaur G, Geethakumari PR, Afrough A, Awan FT, Anderson LD, Vusirikala M, Collins RH, Chen W, Agathocleous M, Madanat YF,
2023 Feb
Leuk Res
125
107001
Zahid MF, Moriarty K, Dryden C, Weinberg O, Asif M, Ikpefan R, Anderson JM, Collins RH, Chung SS, Chen W, Patel PA, Madanat YF,
2023 Aug
Eur J Haematol
Hoff FW, Goksu SY, Premnath N, Patel PA, Ikpefan R, Kaur G, Vusirikala M, Bat T, Chen W, Geethakumari PR, Anderson LD, Awan FT, Collins RH, Weinberg OK, Muthukumar A, Chung SS, Madanat YF,
2023 Apr
Acta Med Acad
1
52
30-36
Hoff FW, Chung SS, Patel PA, Premnath N, Khatib J, Tadic-Ovcina M, AhmedRabie A, Helton D, Yohannes S, Shahan J, Patel H, Geethakumari PR, Vusirikala M, Collins RH, Madanat YF,
2023 Apr
Transpl Immunol
77
101808
Hsieh HH, Yao H, Ma Y, Zhang Y, Xiao X, Stephens H, Wajahat N, Chung SS, Xu L, Xu J, Rampal RK, Huang LJ,
2022 Sep
Blood
Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance.
Lyu J, Liu Y, Gong L, Chen M, Madanat YF, Zhang Y, Cai F, Gu Z, Cao H, Kaphle P, Kim YJ, Kalkan FN, Stephens H, Dickerson KE, Ni M, Chen W, Patel P, Mims AS, Borate U, Burd A, Cai SF, Yin CC, You MJ, Chung SS, Collins RH, DeBerardinis RJ, Liu X, Xu J, 2022 Oct Cancer Discov
Oertling E, Fuda F, Koduru P, Chen M, Weinberg O, Juntilla M, Jaso J, Vusirikala M, Chung S, Geethakumari PR, Madanat YF, Collins R, Gagan J, Chen W,
2022 Nov
Leuk Res
124
106995
Liu Y, Gu Z, Cao H, Kaphle P, Lyu J, Zhang Y, Hu W, Chung SS, Dickerson KE, Xu J,
2021 11
Nat Commun
1
12
6323
Bergstrom CP, Dahiya S, Chen W, Zhang CC, Zhu H, Yan J, Madanat Y, Patel P, Vusirkala M, Ramakrishnan P, Rizvi S, Chung S, Awan F, Anderson LD, Collins R, Kansagra A,
2020 Nov
Leuk Res
100
106480
Taylor J, Mi X, Penson AV, Paffenholz SV, Alvarez K, Sigler A, Chung SS, Rampal RK, Park JH, Stein EM, Tallman MS, Sen F, Gönen M, Abdel-Wahab O, Klimek VM,
2020 Aug
Lancet Haematol
8
7
e566-e574
Chung SS,
2019 12
Leuk Lymphoma
13
60
3102-3103
CD97 is a critical regulator of acute myeloid leukemia stem cell function.
Martin GH, Roy N, Chakraborty S, Desrichard A, Chung SS, Woolthuis CM, Hu W, Berezniuk I, Garrett-Bakelman FE, Hamann J, Devlin SM, Chan TA, Park CY, 2019 10 J Exp Med 10 216 2362-2377Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies.
Taylor J, Pavlick D, Yoshimi A, Marcelus C, Chung SS, Hechtman JF, Benayed R, Cocco E, Durham BH, Bitner L, Inoue D, Chung YR, Mullaney K, Watts JM, Diamond EL, Albacker LA, Mughal TI, Ebata K, Tuch BB, Ku N, Scaltriti M, Roshal M, Arcila M, Ali S, Hyman DM, Park JH, Abdel-Wahab O 2018 Aug J. Clin. Invest. 9 128 3819-3825
Chung SS, Park CY
2017 Dec
Blood Adv
26
1
2572-2578
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.
Li S, Garrett-Bakelman FE, Chung SS, Sanders MA, Hricik T, Rapaport F, Patel J, Dillon R, Vijay P, Brown AL, Perl AE, Cannon J, Bullinger L, Luger S, Becker M, Lewis ID, To LB, Delwel R, Löwenberg B, Döhner H, Döhner K, Guzman ML, Hassane DC, Roboz GJ, Grimwade D, Valk PJ, D'Andrea RJ, Carroll M, Park CY, Neuberg D, Levine R, Melnick AM, Mason CE 2016 07 Nat. Med. 7 22 792-9Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia.
Tiacci E, Park JH, De Carolis L, Chung SS, Broccoli A, Scott S, Zaja F, Devlin S, Pulsoni A, Chung YR, Cimminiello M, Kim E, Rossi D, Stone RM, Motta G, Saven A, Varettoni M, Altman JK, Anastasia A, Grever MR, Ambrosetti A, Rai KR, Fraticelli V, Lacouture ME, Carella AM, Levine RL, Leoni P, Rambaldi A, Falzetti F, Ascani S, Capponi M, Martelli MP, Park CY, Pileri SA, Rosen N, Foà R, Berger MF, Zinzani PL, Abdel-Wahab O, Falini B, Tallman MS 2015 Oct N. Engl. J. Med. 18 373 1733-47
Tamari R, Chung SS, Papadopoulos EB, Jakubowski AA, Hilden P, Devlin SM, Goldberg JD, Perales MA, Ponce DM, Sauter CS, Maloy MA, Herman DY, Klimek V, Young JW, O'Reilly RJ, Giralt SA, Castro-Malaspina H
2015 Dec
Biol. Blood Marrow Transplant.
12
21
2106-2114
miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a.
Hu W, Dooley J, Chung SS, Chandramohan D, Cimmino L, Mukherjee S, Mason CE, de Strooper B, Liston A, Park CY 2015 Apr Blood 14 125 2206-16
Davila ML, Riviere I, Wang X, Bartido S, Park J, Curran K, Chung SS, Stefanski J, Borquez-Ojeda O, Olszewska M, Qu J, Wasielewska T, He Q, Fink M, Shinglot H, Youssif M, Satter M, Wang Y, Hosey J, Quintanilla H, Halton E, Bernal Y, Bouhassira DC, Arcila ME, Gonen M, Roboz GJ, Maslak P, Douer D, Frattini MG, Giralt S, Sadelain M, Brentjens R
2014 Feb
Sci Transl Med
224
6
224ra25
Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia.
Shih AH, Chung SS, Dolezal EK, Zhang SJ, Abdel-Wahab OI, Park CY, Nimer SD, Levine RL, Klimek VM 2013 Jun Haematologica 6 98 908-12
Dey BR, Chung SS, Spitzer TR, Zheng H, Macgillivray TE, Seldin DC, McAfee S, Ballen K, Attar E, Wang T, Shin J, Newton-Cheh C, Moore S, Sanchorawala V, Skinner M, Madsen JC, Semigran MJ
2010 Oct
Transplantation
8
90
905-11
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The Chung lab is looking for highly motivated individuals to pursue projects leveraging cutting-edge technologies to study in vitro and in vivo models of hematopoiesis, with extensive use of mouse models of disease and stem cell transplantation assays.