Publications for Jef De Brabander, Ph.D.

  1. De Brabander JK, Dong X, Liang Q, Pan Y-Z, Wang X, Kuo Y-C, Chiang W-C, Zhang X, Williams N, Rizo J, Levine B (2022) Novel Bcl-2 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2⎯Beclin 1 Protein⎯Protein Interaction. ACS Chem. Biol. ; https://doi.org/10.1021/acsmedchemlett.2c00309
  2. Povedano JM, Li V, Lake KE, Bai X, Rallabandi R, Kim J, Xie Y, De Brabander JK, McFadden DG (2022) TK216 targets microtubules in Ewing sarcoma cells. Cell Chem. Biol., 29, 1325-1332; https://doi.org/10.1016/j.chembiol.2022.06.002; PMID: 35803262; PMC939468
  3. Yin J, Kang Y, McGrath A, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM (2022) Molecular mechanism of the wake-promoting agent TAK-925. Nature Commun. 13, Article number: 2902. https://doi.org/10.1038/S41467-022-30601-3; PMID: 35614071; PMC9133036
  4. Hollibaugh R, Yu X, De Brabander JK (2020) A convergent approach toward fidaxomicin: Synthesis of the fully glycosylated northern and southern fragments. Tetrahedron, 76, 131673; https://doi.org/10.1016/j.tet.2020.131673; PMID: 33191957; PMC7665079
  5. Povedano JM, Rallabandi R, Bai X, Ye X, Liou J, Chen H, Kim J, Xie Y, Posner B, Rice B, De Brabander JK, McFadden DG (2020) A Multipronged Approach Establishes Covalent Modification of b-Tubulin as the Mode of Action of Benzamide Anti-Cancer Toxins. Med. Chem., 63, 14054-14066; https://doi.org/10.1021/acs.jmedchem.0c01482; PMID: 33180487; PMC7707623
  6. Jung H, Takeshima T, Nakagawa T, MacMillan KS, Wynn RM, Wang H, Sakiyama H, Wei S, Li Y, Bruick RK, Posner BA, De Brabander JK, Uyeda K (2020) The Structure of Importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP-Importin α interactions. J., 477, 3253-3269; https://doi.org/10.1042/BCJ20200520; PMID: 32776146; PMC7489895
  7. Theodoropoulos PC, Wang W, Budhipramono A, Thompson B; Madhusudhan N, Mitsche MA, McDonald JG; De Brabander JK, Nijhawan D (2020) A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins. Am. Chem. Soc., 142, 6128-6138; https://doi.org/10.1021/jacs.9b13407; PMID: 32163279; PMC7236545
  8. Long T, Qi X, Hassan A, Liang Q, De Brabander JK, Li X (2020) Structural basis for itraconazole-mediated NPC1 inhibition. Commun. 11:151; https://doi.org/10.1038/s41467-019-13917-5; PMCID: PMC6952396
  9. Wang W, Zhang L, Morlock L, Williams NS, Shay JW, De Brabander JK (2019) Design and Synthesis of TASIN Analogs Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC). Med. Chem., 62, 5217-5241; https://doi.org/10.1021/acs.jmedchem.9b00532; PMID: 31070915; PMC725524
  10. Gong J, Li W, Fu P, MacMillan J, De Brabander JK (2019) Isolation, Structure, and Total Synthesis of the Marine Macrolide Mangrolide D. Lett., 21, 2957-2961; https://doi.org/10.1021/acs.orglett.9b01126; PMID: 30957503; PMC6526702
  11. Shi Y, Lim SK, Liang Q, Iyer SV, Wang H-Y, Wang Z, Xie X, Chen Y-J, Tabar V, Gutin P, Williams N, De Brabander JK, Parada LF (2019) Vulnerability of glioma to a novel proton gradient dependent oxidative phosphorylation inhibitor. Nature, 567, 341-346; https://doi.org/10.1038/s41586-019-0993-x; PMID: 30842654
  12. Bender CF, Paradise CL, Lynch VM, Yoshimoto FK, De Brabander JK (2018) A biosynthetically inspired synthesis of (–)-berkelic acid and analogs. Tetrahedron, 74, 909-919; https://doi.org/10.1016/j.tet.2018.01.021; (Tetrahedron Symposium-in-Print: “Biogenetic Considerations in Complex Synthesis”). PMID: 29867257. PMCID: PMC5983035
  13. Bulanova D, Ianevski A, Bugai A, Akimov Y, Kuivanen S, Paavilainen H, Kakkola L, Nandania J, Turunen L, Ohman T, Ala-Hongisto H, Pesonen HM, Kuisma MS, Honkimaa A, Walton EL, Oksenych V, Lorey MB, Guschin D, Shim J, Kim J, Than TT, Chang SY, Hukkanen V, Kulesskiy E, Marjomaki VS, Julkunen I, Nyman TA, Matikainen S, Saarela JS, Sane F, Hober D, Gabriel G, De Brabander JK, Martikainen M, Windisch MP, Min J-Y, Aittokallio T, Bruzzone R, Vähä-Koskela M, Vapalahti O, Pulk A, Velagapudi V, Kainov DE (2017) Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins. Viruses, 9, 271; https://doi.org/10.3390/v9100271; PMCID: PMC5691623
  14. Brockway AJ, Volkov OA, Cosner CC, MacMillan KS, Wring SA, Richardson TE, Peel M, Phillips MA, De Brabander JK (2017) Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) – an inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. Med. Chem. 25, 5433-5440; http://dx.doi.org/10.1016/j.bmc.2017.07.063; PMID: 28807574. PMCID: PMC5632197
  15. Deng Y, Wang ZV, Gordillo R, An Y, Zhang C, Liang Q, Yoshino J, Cautivo KM, De Brabander J, Elmquist JK, Horton JD, Hill JA, Klein S, Schrerer PE (2017) An Adipo-Biliary-Uridine Axis that Regulates Energy Homeostasis. Science, 355 (6330), eaaf5375; https://doi.org/10.1126/science.aaf5375; PMID: 28302796
  16. Kuivanen S, Bespalov MM, Nandania J, Ianevsky A, Velagapudi V, De Brabander JK, Kainov DE, Vapalahti O (2017) Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism; Antiviral Res. 139, 117-128; https://doi.org/10.1016/j.antiviral.2016.12.022; PMID: 28049006
  17. Volkov OA, Cosner CC, Brockway AJ, Kramer M, Booker M, Zhong S, Ketcherside KA, Wei S, Longgood J, McCoy M, Richardson TE, Wring SA, Peel M, Klinger JD, Posner BA, De Brabander JK, Phillips MA (2017) Identification of Trypanosoma brucei AdoMetDC inhibitors using a high-throughput mass spectrometry based assay. ACS Dis., 7, 512-526; https://doi.org/10.1021/acsinfecdis.7b00022; PMCID: PMC5511061
  18. Trinh MN, Lu F, Li X, Das A, Liang Q, De Brabander JK, Brown, MS, Goldstein JL (2017) Triazoles inhibit cholesterol export from lysosomes by binding to NPC1. Natl. Acad. Sc. USA, 114, 89-94; https://doi.org/10.1073/pnas.1619571114; PMID: 27994139. PMC5224357
  19. Gaelings L, Söderholm S, Bugai A, Fu Y, Nandania J, Schepens B, Lorey MB, Tynell J, Vande Ginste L, Le Goffic R, Miller MS, Kuisma M, Marjomäki V, De Brabander J, Matikainen S, Nyman TA, Bamford D, Saelens X, Julkunen I, Paavilainen H, Hukkanen V, Velagapudi V, Kainov DE (2017) Regulation of Kynurenine Biosynthesis during Influenza Virus Infection. The FEBS Journal 284, 222-236; https://doi.org/10.1111/febs.13966; PMID: 27860276. (Selected by the Editor in Chief as Editor’s Choice Paper: Boergeling Y, Ludwig S (2017) Targeting a metabolic pathway to fight the flu. The FEBS Journal 284, 218-221. Freely available in Virtual Issue of Editor’s Choice Papers at: http://onlinelibrary.wiley.com/doi/10.1111/febs.13997/epdf)
  20. Eskiocak B, McMillan EA, Mendiratta S, Kollipara RK, Zhang H, Humphries CG, Wang C, Garcia-Rodriguez J, Ding M, Zaman A, Rosales TI, Eskiocak U, Smith MP, Sudderth J, Komurov K, DeBerardinis RJ, Wellbrock C, Davies MA, Wargo JA, Yu Y, De Brabander JK, Williams NS, Chin L, Rizos H, Long GV, Kittler R, White MA (2017) Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma. Cancer Discovery 7(8), 832-851; https://doi.org/10.1158/2159-8290.CD-16-0955; PMID: 28455392 PMCID: PMC5540806
  21. Kissing S, Rudnik S, Damme M, Lüllmann-Rauch R, Ichihara A, Kornak U, Eskelinen E-L, Jabs S, Heeren J, De Brabander JK, Haas A, Saftig P (2017) Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes. Authophagy 13 (4), 670-685; http://dx.doi.org/10.1080/15548627.2017.1280216; PMCID: PMC5388235
  22. Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon Y-A, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW (2016) Selective Targeting of Mutant Adenomatous Polyposis Coli (APC) in Colorectal Cancer. Science Translational Medicine 8, issue 361, pp. 361ra140; https://doi.org/10.1126/scitranslmed.aaf8127; PMID: 27798265 (Subject of commentary in ‘Nature Reviews Drug Discovery; Research Highlights, 2016, issue 15, pp 820-821; https://doi.org/10.1038/nrd.2016.247
  23. Feng Y, Liu J, Carrasco YP, MacMillan JB, De Brabander JK (2016) Rifamycin Biosynthetic Congeners: Isolation and Total Synthesis of Rifsaliniketal and Total Synthesis of Salinisporamycin and Saliniketals A and B. Journal of the American Chemical Society 138, 7130-7142; https://doi.org/10.1021/jacs.6b03248; PMID: 27232659
  24. Sato S, Jung H, Nakagawa T, Pawlosky R, Takeshima T, Lee W-R, Sakiyama H, Laxman S, Wynn RM, Tu B, MacMillan JB, De Brabander JK, Veech RL, Uyeda K (2016) Metabolite Regulation of Nuclear Localization of Carbohydrate Response Element-binding Protein (ChREBP). Role of AMP as an Allosteric Inhibitor. Biol. Chem. 291, 10515-10527; https://doi.org/10.1074/jbc.M115.708982; PMID: 26984404; PMCID: PMC4865902
  25. Brockway AJ, Cosner CC, Volkov OA, Phillips MA, De Brabander JK (2016) Improved Synthesis of MDL 73811 – a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound. Synthesis 48, 2065-2068; https://doi.org/10.1055/s-0035-1561608 ; PMID: 27482123; PMCID: PMC4966539
  26. Immuno-​modulating properties of saliphenylhalamide, SNS-​032, obatoclax, and gemcitabine
    Soderholm, S.; Anastasina, M.; Islam, M. M.; Tynell, J.; Poranen, M. M.; Bamford, D. H.; Stenman, J.; Julkunen, I.; Sauliene, I.; De Brabander, J. K.; Matikainen, S.; Nyman, T. A.; Saelens, X.; Kainov, D. Antiviral Research 2016, 126, 69.
  27. Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
    Lu, F.; Liang, Q.; Abi-Mosleh, L.; Das, A.; De Brabander, J. K.; Goldstein, J. L.; Brown, M. S. eLife 2015, 4, e12177.
  28. Synthesis and structure–activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs
    Garcia-Rodriguez, J.; Mendiratta, S.; White, M. A.; Xie, X.-S.; De Brabander, J. K. Med. Chem. Lett. 2015, 25, 4393.
  29. Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model
    Meyer, C. J.; Krauth, M.; Wick, M.; Shay, J. W.; Gellert, G.; De Brabander, J. K.; Northcote, P. T.; Miller, J. H. Mol. Cancer Ther. 2015, 14, 1816.
  30. Vacuolar ATPase in Phagosome-Lysosome Fusion
    Kissing, S.; Hermsen, C.; Repnik, U.; Nesset, C. K.; von Bargen, K.; Griffiths, G.; Ichihara, A.; Lee, B. S.; Schwake, M.; De Brabander, J.; Haas, A.; Saftig, P. J. Biol. Chem. 2015, 290, 14166.
  31. Ligand-free copper-catalyzed coupling of α-amino acids with N-Boc-2-iodoanilines for the synthesis of enantiopure 3-substituted dihydroquinoxalinones
    Luo, S.; De Brabander, J. K. Tetrahedron Lett. 2015, 56, 3179.
  32. Inhibition by Cellular Vacuolar ATPase Impairs Human Papillomavirus Uncoating and Infection
    Müller, K. H.; Spoden, G. A.; Scheffer, K. D.; Brunnhöfer, R.; De Brabander, J. K.; Maier, M. E.; Florin, L.; Muller, C. P. Antimicrob. Agents Chemother. 2014, 58, 2905.
  33. Preclinical Therapeutic Efficacy of a Novel Pharmacologic Inducer of Apoptosis in Malignant Peripheral Nerve Sheath Tumor
    Chau, V.; Lim, S. K.; Mo, W.; Liu, C.; Patel, A. J.; McKay, R. M.; Wei, S.; Posner, B. A.; De Brabander, J. K.; Williams, N. S.; Parada, L. F.; Le, L. Q. Cancer Res. 2014, 74, 586.
  34. Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer
    Kim, H. S.; Mendiratta, S.; Kim, J.; Pecot, C. V.; Larsen, J. E.; Zubovych, I.; Seo, B. Y.; Kim, J.; Eskiocak, B.; Chung, H.; McMillan, E.; Wu, S.; De Brabander, J.; Komurov, K.; Toombs, J. E.; Wei, S.; Peyton, M.; Williams, N.; Gazdar, A. F.; Posner, B. A.; Brekken, R. A.; Sood, A. K.; Deberardinis, R. J.; Roth, M. G.; Minna, J. D.; White, M. A. Cell 2013, 155, 552.
  35. Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles
    Bimbo, L. M.; Denisova, O. V.; Mäkilä, E.; Kaasalainen, M.; De Brabander, J. K.; Hirvonen, J.; Salonen, J.; Kakkola, L.; Kainov, D.; Santos, H. A. ACS Nano 2013, 7, 6884.
  36. SAR-Based Optimization of a 4-Quinoline Carboxylic Acid Analogue with Potent Antiviral Activity
    Das, P.; Deng, X.; Zhang, L.; Roth, M. G.; Fontoura, B. M. A.; Phillips, M. A.; De Brabander, J. K. ACS Med. Chem. Lett. 2013, 4, 517.
  37. Studies toward the Unique Pederin Family Member Psymberin: Structure–Activity Relationships, Biochemical Studies, and Genetics Identify the Mode-of-Action of Psymberin
    Wu, C.-Y.; Feng, Y.; Cardenas, E. R.; Williams, N.; Floreancig, P. E.; De Brabander, J. K.; Roth, M. G. J. Am. Chem. Soc. 2012, 134, 18998.
  38. Obatoclax, Saliphenylhalamide, and Gemcitabine Inhibit Influenza A Virus Infection
    Denisova, O. V.; Kakkola, L.; Feng, L.; Stenman, J.; Nagaraj, A.; Lampe, J.; Yadav, B.; Aittokallio, t.; Kaukinen, P.; Ahola, T.; Kuivanen, S.; Vapalahti, O.; Kantele, A.; Tynell, J.; Julkunen, I.; Kallio-Kokko, H.; Paavilainen, H.; Hukkanen, V.; Elliott, R. M.; De Brabander, J. K.; Saelens, X.; Kainov, D. E. J. Biol. Chem. 2012, 287, 35324.
  39. Studies toward the Unique Pederin Family Member Psymberin: Full Structure Elucidation, Two Alternative Total Syntheses, and Analogs
    Feng, Y.; Jiang, X.; De Brabander, J. K. J. Am. Chem. Soc. 2012, 134, 17083.
  40. Inhibition of Pyrimidine Synthesis Reverses Viral Virulence Factor-mediated Block of mRNA Nuclear Export
    Zhang, L.; Das, P.; Schmolke; M.; Manicassamy, B.; Wang, Y.; Deng, X.; Cai, L.; Tu, B. P.; Forst, C. V.; Roth, M. G.; Levy, D. E.; García-Sastre, A.; De Brabander, J. K.; Phillips, M. A.; Fontoura, B. M.A. J. Cell Biol. 2012, 196, 315.
  41. Lessons and Revelations from Biomimetic Syntheses
    Razzak, M.; De Brabander, J. K. Nature Chemical Biology 2011, 7, 865.
  42. Platinum-Catalyzed Synthesis of β-Keto Tetrahydropyrans and Cyclic Dienolethers
    Liang, Q.; Qian, M.; Razzak, M.; De Brabander, J. K. Chem. Asian J. 2011, 6, 1958.
  43. Heterocycles via Intramolecular Platinum-Catalyzed Propargylic Substitution
    Liang, Q.; De Brabander, J. K. Tetrahedron 2011, 67, 5046.
  44. Gold-Catalysed Synthesis of Amino Acid-Derived 2,5-Disubstituted Oxazoles
    Paradise, C. L.; Sarkar, P. R.; Razzak, M.; De Brabander, J. K. Org. Biomol. Chem. 2011, 9, 4017.
  45. Development of Proneurogenic, Neuroprotective Small Molecules
    MacMillan, K. S.; Naidoo, J.; Liang, J.; Melito, L.; Williams, N. S.; Morlock, L.; Huntington, P. J.; Estill, S. J.; Longgood, J.; Becker, G. L.; McKnight, S. L.; Pieper, A. A.; De Brabander, J. K.; Ready, J. M. J. Am. Chem. Soc. 2011, 133, 1428.
  46. Discovery of a Proneurogenic, Neuroprotective Chemical
    Pieper, A. A.; Xie, S.; Capota, E.; Estill, S. J.; Zhong, J.; Long, J. M.; Becker, G. L.; Huntington, P.; Goldman, S. E.; Shen, C.-H.; Capota, M.; Britt, J. K.; Kotti, T.; Ure, K.; Brat, D. J.; Williams, N. S.; MacMillan, K.S.; Naidoo, J.; Melito, L.; Hsieh, J.; De Brabander, J. K.; Ready, J. M.; McKnight, S. L. Cell 2010, 142, 39.
  47. Inhibition of Iron Uptake Is Responsible for Differential Sensitivity to V-ATPase Inhibitors in Several Cancer Cell Lines
    Straud, S.; Zubovych, I.; De Brabander, J. K.; Roth, M. G. PloS ONE 2010, 5, e11629.
  48. Expanded Utility of the β-Glucuronide Linker: ADCs That Deliver Phenolic Cytotoxic Agents
    Jeffrey, S. C.; De Brabander, J. K.; Miyamoto, J.; Senter, P. D. ACS Med. Chem. Lett. 2010, 1, 277.
  49. A Concise Total Synthesis of Saliniketal B
    Liu, J.; De Brabander, J. K. J. Am. Chem. Soc. 2009, 131, 12562.
  50. A Concise Synthesis of Berkelic Acid Inspired by Combining the Natural Products Spicifernin and Pulvilloric Acid
    Bender, C. F.; Yoshimoto, F. K.; Paradise, C. L.; De Brabander, J. K. J. Am. Chem. Soc. 2009, 131, 11350.
  51. Evaluating the potential of Vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide
    Lebreton, S.; Jaunbergs, J.; Roth, M. G.; Ferguson, D. A.; De Brabander, J. K. Bioorg. Med. Chem. Lett. 2008, 18, 5879.
  52. Au(I)- and Pt(II)-Catalyzed Cycloetherification of ω-Hydroxy Propargylic Esters
    De Brabander, J. K.; Liu, B.; Qian, M. Org. Lett. 2008, 10, 2533.
  53. Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A
    Jiang, X.; Liu, B.; Lebreton, S.; De Brabander, J. K. J. Am. Chem. Soc. 2007, 129, 6386.
  54. Synthesis of Psymberin Analogues: Probing a Functional Correlation with the Pederin/Mycalamide Family of Natural Products
    Jiang, X.; Williams, N.; De Brabander, J. K. Org. Lett. 2007, 9, 227.
  55. Metal-Catalyzed Regioselective Oxy-Functionalization of Internal Alkynes: An Entry into Ketones, Acetals, and Spiroketals
    Liu, B.; De Brabander, J. K. Org. Lett. 2006, 8, 4907.
  56. Synthesis of spirastrellolide A fragments for structure elucidation 
    Pan, Y.; De Brabander, J. K. Synlett  2006, 853.
  57. Synthesis and Complete Stereochemical Assignment of Psymberin/Irciniastatin A
    Jiang, X.; Garcia-Fortanet, J.; De Brabander, J. K. J. Am. Chem. Soc. 2005, 127, 11254.
  58. A Concise Synthesis of (+)-SCH 351448
    Soltani, O.; De Brabander, J. K. Org. Lett. 2005, 7, 2791.
  59. Synthesis of functionalized salicylate esters and amides by photochemical acylation
    Soltani, O.; De Brabander, J. K. Angew. Chem. Int. Ed. 2005, 44, 1696.
  60. A Photochemical Entry to Depsides: Synthesis of Gustastatin
    Garcia-Fortanet, J.; Debergh, J. R.; De Brabander, J. K. Org. Lett. 2005, 7, 685.
  61. Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs
    Adams, C. M.; Reitz, J.; De Brabander, J. K.; Feramisco, J. D.; Li, L.; Brown, M. S.; Goldstein, J. L. J. Biol. Chem. 2004, 279, 52772.
  62. Ring-closing metathesis: a powerful tool for the synthesis of simplified salicylihalamide-based V-ATPase inhibitors
    Lebreton, S.; Xie, X.-S.; Ferguson, D.; De Brabander, J. K. Tetrahedron 2004, 60, 9635.
  63. A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death
    Li, L.; Thomas, R. M.; Suzuki, H.; De Brabander, J. K.; Wang, X.; Harran, P. G. Science 2004, 305, 1471.
  64. Salicylihalamide A inhibits the V0 sector of the V-ATPase through a mechanism distinct from bafilomycin A1
    Xie, X.-S.; Padron, D.; Liao, X.; Wang, J.; Roth, M. G.; De Brabander, J. K. J. Biol. Chem. 2004, 279, 19755.
  65. Total synthesis and absolute configuration of the novel microtubule-stabilizing agent peloruside A
    Liao, X.; Wu, Y.; De Brabander, J. K. Angew. Chem. Int. Ed. 2003, 42, 1648.
  66. Total synthesis and initial structure-function analysis of the potent V-ATPase inhibitors salicylihalamide A and related compounds
    Wu, Y.; Liao, X.; Wang, R.; Xie, X.-S.; De Brabander, J. K. J. Am. Chem. Soc. 2002, 124, 3245.
  67. Synthesis of the C1-C21 (C1'-C21') Fragment of the Dimeric Polyketide Natural Product SCH 351448
    Bhattacharjee, A.; Soltani, O.; De Brabander, J. K. Org. Lett. 2002, 4, 481.
  68. Total synthesis and biological evaluation of apicularen A and synthetic analogs
    Bhattacharjee, A.; Seguil, O. R.; De Brabander, J. K. Tetrahedron Lett. 2001, 42, 1217.
  69. Revision of the absolute configuration of salicylihalamide A through asymmetric total synthesis
    Wu, Y.; Esser, L.; De Brabander, J. K. Angew. Chem. Int. Ed. 2000, 39, 4308.
  70. Synthesis and Initial Structure-Activity Relationships of Modified Salicylihalamides
    Wu, Y.; Seguil, O. R.; De Brabander, J. K. Org. Lett. 2000, 2, 4241.
  71. Synthesis of side chain truncated apicularen A
    Bhattacharjee, A.; De Brabander, J. K. Tetrahedron Lett. 2000, 41, 8069.
  72. The chemistry-medicine continuum: synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leads
    Wender, P. A.; Martin-Cantalejo, Y.; Carpenter, A. J.; Chiu, A.; De Brabander, J. K.; Harran, P. G.; Jimenez, J.-M.; Koehler, M. F. T.; Lippa, B.; Morrison, J. A.; Müller, S. G.; Müller, S. N.; Park, C.-M.; Shiozaki, M.; Siedenbiedel, C.; Skalitzky, D. J.; Tanaka, M.; Irie, K. Pure & Appl. Chem. 1998, 70, 539.
  73. The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1 
    Wender, P. A.; De Brabander, J. K.; Harran, P. G.; Jimenez, J.-M.; Koehler, M. F. T.; Lippa, B.; Park, C.-M.; Siedenbiedel, C.; Pettit, G. R. Proc. Nat. Acad. Sci. 1998, 95, 6624.
  74. Synthesis of the First Members of a New Class of Biologically Active Bryostatin Analogues
    Wender, P. A.; De Brabander, J. K.; Harran, P. G.; Jimenez, J.-M.; Koehler, M. F. T.; Lippa, B.; Park, C.-M.; Shiozaki, M. J. Am. Chem. Soc. 1998,120, 4534.
  75. (R)-Carvone as chiral template for the synthesis of some polyols 
    De Brabander, J. K.; Kulkarni, B. A.; Garcia-Lopez, R.; Vandewalle, M. Bulletin des Societes Chimiques Belges 1997, 106, 665.
  76. Non-destructive removal of the bornanesultam auxiliary in α-substituted N-acylbornane-10,2-sultams under mild conditions. An efficient synthesis of enantiomerically pure ketones and aldehydes
    Oppolzer, W.; Darcel, C.; Rochet, P.; Rosset, S.; De Brabander, J. K. Helv. Chim. Act. 1997, 80, 1319.
  77. Towards a synthesis of epothilone A. Rapid assembly of the C(1)-C(6) and C(7)-C(12) fragments
    De Brabander, J. K.; Rosset, S.; Bernardinelli, G. Synlett 1997, 824.
  78. Enantioselective total synthesis of (–)-denticulatins A and B using a novel group-selective aldolization of a meso dialdehyde as a key step
    De Brabander, J. K.; Oppolzer, W. Tetrahedron 1997, 53, 9169.
  79. Bryostatin: a novel asymmetric synthesis of the C27-C34 fragment starting from (R)-carvone as chiral template
    De Brabander, J. K.; Kulkarni, B. A.; Garcia-Lopez, R.; Vandewalle, M. Tetrahedron: Asymmetry 1997, 8, 1721.
  80. Asymmetric synthesis of ibuprofen via diastereoselective alkylation of a homochiral N-acylbornanesultam
    Oppolzer, W.; Rosset, S.; De Brabander, J. K. Tetrahedron Lett. 1997, 38, 1539.
  81. Enantioselective synthesis of the Prelog-Djerassi lactonic acid via group-selective aldolization/desymmetrization of a meso dialdehyde with a chiral N-propionylsultam
    Oppolzer, W.; Walther, E.; Balado, C. P.; De Brabander, J. K. Tetrahedron Lett. 1997, 38, 809.
  82. Towards the asymmetric synthesis of bryostatin 1
    De Brabander, J. K.; Vandewalle, M. Pure & Appl. Chem. 1996, 68, 715.
  83. Asymmetric synthesis of (–)-denticulatins A and B via group-selective aldolization of a meso dialdehyde with a chiral N-propionylsultam
    Oppolzer, W.; De Brabander, J. K.; Walther, E.; Bernardinelli, G. Tetrahedron Lett. 1995, 36, 4413.
  84. Total synthesis of the macrolide (+)-aspicilin by an asymmetrically catalyzed macrocyclization of an ω-alkynal ester
    Oppolzer, W.; Radinov, R. N.; De Brabander, J. K. Tetrahedron Lett. 1995, 36, 2607.
  85. Bryostatins: the asymmetric synthesis of the C1-C9 and C17-C27 fragments
    De Brabander, J. K.; Vandewalle, M. Synthesis 1994, 855.
  86. Bryostatins: the asymmetric synthesis of C1-C9 and C11-C16 fragments
    De Brabander, J. K.; Vanhessche, K.; Vandewalle, M. Tetrahedron Lett. 1991, 32, 2821.
  87. Chemistry of the transition metals: application to organic synthesis
    De Brabander, J. K. Chemie Magazine 1989, 15, 23.
  88. The Protective Effect of Behavioral Activation on the Growth of a Syngeneic Tumor and Mortality in Socially Stressed Mice
    De Brabander, B.; D'haeseleer, F.; De Brabander, M.; Distelmans, W.; Van Ginckel, R.; De Brabander, J. K. Eur. J. Psychiat., 1989, 3, 238.

Patents

  1. Substituted benzimidazolium, pyrido-imidazolium, or pyrazino-imidazolium compounds as chemotherapeutics.
    De Brabander, J. K.; Parada, L. F.; Lim, S. K.; Liang, Q.; Wang, H.-Y.; Shi, Y. Provisional Patent Appl. (Dec. 11, 2015); Serial Number 62/266,427.
  2. Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol synthesis.
    De Brabander, J. K.; Nijhawan, D.; Wang, W.; Theodoropoulos, P. Patent Appl. (July 5, 2015); Serial Number 62/189,069.
  3. Benzamide or benzamine compounds useful as anticancer agents for the treatment of human cancers.
    De Brabander, J. K.; Parada, L.; Dierick, S.; Lim, K. Patent Appl. (July 5, 2015); Serial Number 62/193,019.
  4. Small-Molecule Agonists for Type-2 Orexin Receptor.
    Yanagisawa, M.; De Brabander, J. K.; Kumagai, H. Patent Appl. (August 20, 2012); Serial Number 3/590,064.  Issued as patent number US 8,871,794.
  5. Small-Molecule Agonists for Type-2 Orexin Receptor.
    Yanagisawa, M.; De Brabander, J. K.; Kumagai, H. Patent Appl. (June 4, 2009); Serial Number 12/478,753.  Issued as patent number US 8,258,163.
  6. Small Molecule Compounds Selective against Gram-Negative Bacterial Infections.
    De Brabander, J. K.; MacMillan, J. B. Patent Appl. (May 13, 2014); Serial Number 61/992,642.
  7. Compositions and Methods to Treat the Bihormonal Disorder in Diabetes.
    Unger, R.; De Brabander, J.; Roth, M.; Evans, M. Patent Appl. Pub. Number US20150037361 A1 and WO2015017642A1.
  8. Therapeutics Targeting Truncated Adenomatous Polyposis Coli (APC) Proteins.
    De Brabander, J.; Shay, J. Patent Appl. (September 10, 2013); PCT/US14/0549.
  9. Methods for Treating Parkinson’s Disease Using Pro-Neurogenic Compounds.
    McKnight, S.L.; Pieper, A.A.; Ready, J.M.; De Brabander, J. Issued as patent number U.S. 8,877,797.
  10. Methods of treating traumatic brain injury using pro-neurogenic compounds.
    McKnight, S.L.; Pieper, A.A.; Ready, J.M.; De Brabander, J. Issued as patent number US 8,791,149 B2.
  11. Methods of treating post- traumatic stress disorder using pro-neurogenic compounds.
    McKnight, S.L.; Pieper, A.A.; Ready, J.M.; De Brabander, J. Issued as patent number US 8,748,473 B2.
  12. Methods for treating amyotrophic lateral sclerosis using pro-neurogenic compounds.
    McKnight, S.L.; Pieper, A.A.; Ready, J.M.; De Brabander, J. Issued as patent number US 8,735,440 B2.
  13. Pro-neurogenic Compounds
    McKnight, S. L.; Pieper, A.; Ready, J.; De Brabander, J. K. Patent Appl. (January 11, 2010); Serial Number 12/685,652.  Issued as patent number US 8,362,277 and patent number US 8,604,074.
  14. Palmerolides: Methods of Preparation and Derivatives
    De Brabander, J. K.; Jiang, X.; Liu, B. Issued as patent number US 7,838,691.
  15. Synthesis and Complete Stereochemical Assignment of Psymberin/Irciniastatin for use as Antitumor Compounds.
    De Brabander, J. K.; Jiang, X. Issued as patent number US 7,429,616.
  16. Dimeric Small Molecule Potentiators of Apoptosis.
    Harran, P. G.; Wang, X.; De Brabander, J. K.; Li, L.; Thomas, R. M.; Suzuki, H. Issued as patent number  US 7,309,792.
  17. Synthesis of Peloruside A and Analogs Thereof for Use as Antitumor Agents.
    De Brabander, J. K.; Liao, X. Issued as patent number US20040235939 A1, WO2004074249 A2.
  18. Synthetic Salicylihalamides, Apicularens and Derivatives Thereof.
    De Brabander, J. K.; Wu, Y. Issued as patent number US 6,617,348.
  19. Müller KH, Kainov DE, El Bakkouri K, Saelens X, De Brabander JK, Kittel C, Samm E, de Landtsheer S, Muller CP (2011) The proton translocation domain of cellular vacuolar-ATPase provides a target for the treatment of influenza A virus infections. British Journal of Pharmacology 164, 344-357.
  20. Takeshima T, Lee W-R, Sakiyama H, Laxman S, Wynn RM, Tu B, MacMillan JB, De Brabander JK, Veech RL, Uyeda K (2016) Metabolite Regulation of Nuclear Localization of Carbohydrate Response Element-binding Protein (ChREBP). Role of AMP as an Allosteric Inhibitor. Biol. Chem. First Published online March 16, 2016; doi:10.1074/jbc.M115.708982
  21. Brockway AJ, Cosner CC, Volkov OA, Phillips MA, De Brabander JK (2016) Improved Synthesis of MDL 73811 – a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound. Synthesis, accepted.