Publications for Marc I. Diamond, M.D.

A synthetic heparinoid blocks tau aggregate cell uptake and amplification
Stopschinski BE, Thomas TL, Nadji S, Darvish E, Fan L, Holmes BB, Modi AR, Finnell J, Kashmer OM, Estill-Terpack S, Mirbaha H, Luu HS, Diamond MI, J. Biol. Chem. 2020 Jan

Tau local structure shields an amyloid-forming motif and controls aggregation propensity
Chen D, Drombosky KW, Hou Z, Sari L, Kashmer OM, Ryder BD, Perez VA, Woodard DR, Lin MM, Diamond MI, Joachimiak LA, Nat Commun 2019 06 10 1 2493

Propagation of Protein Aggregation in Neurodegenerative Diseases
Vaquer-Alicea J, Diamond MI Annu. Rev. Biochem. 2019 Mar

Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers
Posey AE, Ruff KM, Harmon TS, Crick SL, Li A, Diamond MI, Pappu RV J. Biol. Chem. 2018 Jan

Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation
Reilly P, Winston CN, Baron KR, Trejo M, Rockenstein EM, Akers JC, Kfoury N, Diamond M, Masliah E, Rissman RA, Yuan SH Neurobiol. Dis. 2017 Oct 106 222-234

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition
Eskandari-Sedighi G, Daude N, Gapeshina H, Sanders DW, Kamali-Jamil R, Yang J, Shi B, Wille H, Ghetti B, Diamond MI, Janus C, Westaway D Mol Neurodegener 2017 10 12 1 72

Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue
Kaufman SK, Thomas TL, Del Tredici K, Braak H, Diamond MI Acta Neuropathol Commun 2017 Jun 5 1 41

FRET and Flow Cytometry Assays to Measure Proteopathic Seeding Activity in Biological Samples
Furman JL, Diamond MI Methods Mol. Biol. 2017 1523 349-359

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo
Kaufman SK, Sanders DW, Thomas TL, Ruchinskas AJ, Vaquer-Alicea J, Sharma AM, Miller TM, Diamond MI Neuron 2016 Nov 92 4 796-812

Neuronal activity enhances tau propagation and tau pathology in vivo
Wu JW, Hussaini SA, Bastille IM, Rodriguez GA, Mrejeru A, Rilett K, Sanders DW, Cook C, Fu H, Boonen RA, Herman M, Nahmani E, Emrani S, Figueroa YH, Diamond MI, Clelland CL, Wray S, Duff KE Nat. Neurosci. 2016 Jun

Prions and Protein Assemblies that Convey Biological Information in Health and Disease
Sanders DW, Kaufman SK, Holmes BB, Diamond MI Neuron 2016 Feb 89 3 433-48

Distinct therapeutic mechanisms of Tau antibodies: promoting microglial clearance vs. blocking neuronal uptake
Funk KE, Mirbaha H, Jiang H, Holtzman DM, Diamond MI J. Biol. Chem. 2015 Jun

Subcellular Localization and Ser-137 Phosphorylation Regulate Tumor-Suppressive Activity of Profilin-1
Diamond MI, Cai S, Boudreau A, Carey CJ, Lyle N, Pappu RV, Swamidass SJ, Bissell M, Piwnica-Worms H, Shao J J. Biol. Chem. 2015 Feb

The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios
Wobst HJ, Sharma A, Diamond MI, Wanker EE, Bieschke J FEBS Lett. 2015 Jan 589 1 77-83

Proteopathic tau seeding predicts tauopathy in vivo
Holmes BB, Furman JL, Mahan TE, Yamasaki TR, Mirbaha H, Eades WC, Belaygorod L, Cairns NJ, Holtzman DM, Diamond MI Proc. Natl. Acad. Sci. U.S.A. 2014 Sep

Distinct tau prion strains propagate in cells and mice and define different tauopathies
Sanders DW, Kaufman SK, DeVos SL, Sharma AM, Mirbaha H, Li A, Barker SJ, Foley AC, Thorpe JR, Serpell LC, Miller TM, Grinberg LT, Seeley WW, Diamond MI Neuron 2014 Jun 82 6 1271-88

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo
Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM Neuron 2013 Oct 80 2 402-14

Advances in diagnostic testing for Alzheimer disease
Schindler SE, McConathy J, Ances BM, Diamond MI Mo Med 2013 Sep-Oct 110 5 401-5

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI Proc. Natl. Acad. Sci. U.S.A. 2013 Aug 110 33 E3138-47