Featured Publications

Severely polarized extracellular acidity around tumor cells. Feng Q, Bennett, Z, Grichuk A, Huang, T, Faubert B, Huang G, Chen M, DeBerardinis, RJ, Sumer RD, Gao J. Nature Biomed. Eng. 2024, doi.org/10.1038/s41551-024-01178-7. PDF

STING licensing of type I dendritic cells potentiates antitumor immunity. Wang J, Li S, Wang M, Wang X, Chen S, Sun Z, Ren X, Huang G, Sumer BD, Yan N, Fu YX, Gao J. Sci. Immunol. 2024, 9, eadj3945. PDF

Lactate increases stemness of CD8+ T Cells to augment anti-tumor immunity. Feng Q, Liu ZD, Yu XX, Huang TY, Chen JH, Wang J, Wilhelm J, Li SX, Song JW, Li W, Sun ZC, Sumer BD, Li B, Fu YX, Gao J. Nature Comm. 2022, 13, 4981. PDF

Prolonged activation of innate immune pathways by a polyvalent STING agonist. Li S, Luo M, Wang Z, Feng Q, Wilhelm J, Wang X, Li W, Wang J, Cholka A, Fu Y, Sumer BD, Yu H, Gao J. Nature Biomed. Eng. 2021, 5, 455-466. PDF

PET imaging of occult tumors by temporal integration of tumour-acidosis signals from pH-sensitive 64CU-labelled polymers. Huang G, Zhao T, Wang C, Nham K, Xiong Y, Gao X, Wang Y, Hao G, Ge W, Sun X, Sumer BD, Gao J. Nature Biomed. Eng. 2019, 4, 314-324. PDF

Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and tend C. elegant lifespan. Wang C, Niederstrasser H, Li Y, Oswald N, Lin R, Jaramillo J, Douglas P, MacMillan E, Wang Z, Brekken R, Posner BA, MacMillan JB, Hang G, Gao J, White MA. Nature Comm. 2017, 8, 2270. PDF

A STING-activating nanovaccine for cancer immunotherapy. Luo M, Wang H, Wang Z, Cai H, Lu Z, Li Y, Du M, Huang G, Wang C, Chen X, Porembka MR, Lea J, Frankel AE, Fu Y, Chen ZJ, Gao J. Nature Nanotech. 2017, 12, 648-654. PDF

A transistor-like pH nanoprobe for tumour detection and Image-guided Surgery. Zhao T, Huang G, Li Y, Yang S, Ramazani S, Lin Z, Wang Y, Ma X, Zeng Z, Luo M, De Boer E, Sun X, Thibodeaux J, Brekken RA, Sun X, Sumer BD, Gao J. Nature Biomed. Eng. 2016, 1, 0006. PDF

Molecular basis of cooperativity in pH-triggered supramolecular self-assembly. Li Y, Zhao T, Wang C, Lin Z, Huang G, Sumer BD, Gao J. Nature Comm. 2016, 7, 13214. PDF

A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles. Wang C, Wang Y, Li Y, Bodemann B, Zhao T, Ma X, Huang G, Hu Z, DeBerardinis RJ, White MA, Gao, J. Nature Comm. 2015, 6, 8524. PDF

A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals. Wang Y, Zhou K, Huang G, Hensley C, Huang X, Ma X, Zhao T, Sumer BD, DeBerardinis RJ, Gao J. Nat. Mater. 2014, 13, 204-212PDF

Ultra-pH-Sensitive nanoprobe library with broad pH tunability and fluorescence emissions. Ma X, Wang Y, Zhao T, Li Y, Su L, Wang Z, Huang G, Sumer BD, Gao J. J. Am. Chem. Soc. 2014, 136, 11085-11092. PDF