Full Publications

143. Zhu M, Kim J, Deng Q, Ricciuti B, Alessi JV, Eglenen-Polat B, Bender M, Huang HC, Kowash RR, Cuevas I, Bennett Z, Gao J, Minna JD, Castrillon DH, Awad MM, Akbay EA. Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden. Cancer Cell, 2023, 41, 1-18.

142. Annapragada A, Sikora A, Marathe H, Liu S, Demetriou M, Fong L, Gao J, Kufe D, Morris Z, Vilar E, Hutson A, Odunsi K. The Cancer Moonshot Immuno-Oncology Translational Network (IOTN) at Age 5: Accelerating Cancer Immunotherapies. J. Natl. Cancer Inst. 2023, 115, 1262-1270. 

141. Wang M, Singh P, Feng Q, Wilhelm J, Bennett ZT, Huang G, Gao J. Elucidation of Protonation Cooperativity of STING-Activating Polymer. Adv. Mater. 2023, 2305255.

140. Feng Q, Liu ZD, Yu XX, Huang TY, Chen JH, Wang J, Wilhelm J, Li SX, Song JW, Li W, Sun ZC, Sumer BD, Li B, Fu YX, Gao J. Lactate Increases Stemness of CD8+ T Cells to Augment Anti-Tumor Immunity. Nature Comm. 2022, 13, 4981. PDF

139. Zi Z, Zhang Z, Feng Q, Kim C, Wang XD, Scherer P, Gao J, Levine B, Yu Y. Quantitative Phosphoproteomic Analyses Identify STK11IP as a Lysosome-Specific Substrate of mTORC1 that Regulates Lysosomal Acidification. Nature Comm. 2022, 13, 1760. PDF

138. Jiang X, Wang J, Zheng X, Yin W, Wilhelm J, Cao J, Huang G, Zhang J, Lu Z, Sumer BD, Lea J, Gao J, Luo M. Intratumoral Administration of STING-activating Nanovaccine Enhances T Cell Immunotherapy.  J. Immunother. Cancer. 2022, 10, e003960. PDF

137. Bhalli H, Chen SQ, Day A, Tillman B, Gordin E, Truelson J, Sher D, Myers L, Gao J, Sumer BD. Factors Associated with Lymph Node Count in Mucosal Squamous Cell Carcinoma Neck Dissection. Laryngoscope. 2021, 131, 1516-1521. PDF

136. Steinkamp PJ, Voscuil FJ, van der Vegt B, Doff JJ, Schepman KP, Vsscher SA, Kelder W, Jayalakshmi Y, Gao J, Sumer BD, van Dam GM, Witjes MJH.  A standardized framework for fluorescence-guided margin assessment for head and neck cancer using a tumor acidosis sensitive optical imaging agent. Mol. Imaging Biol. 2021, 23, 809-817. PDF

135. Bennett ZT, Li S, Sumer BD, Gao J. Polyvalent design in the cGAS-STING pathway. Seminars in Immunology. 2021, 101580, 1044-5323. PDF

134. Li S, Luo M, Wang Z, Feng Q, Wilhelm J, Wang X, Li W, Wang J, Cholka A, Fu Y, Sumer BD, Yu H, Gao J. Prolonged activation of innate immune pathways by a polyvalent STING agonist. Nature Biomed. Eng. 2021, 5, 455-466. PDF

133. Wilhelm J, Quiñones-Pérez M, Wang J, Wang X, Basava VS, Gao J. Antigen folding improves loading efficiency and antitumor efficacy of PC7A nanoparticle vaccine. J. Controlled Release. 2021, 329, 353-360. PDF

132. Wang X, Wilhelm J, Li W, Li S, Wang Z, Huang G, Wang J, Tang H, Khorsandi S, Sun Z, Evers B, Gao, J. Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window. Nature Comm. 2020, 11, 5828. PDF

131. Li S, Bennett ZT, Sumer BD, Gao, J. Nano-Immune-Engineering Approaches to Advance Cancer Immunotherapy: Lessons from Ultra-pH-Sensitive Nanoparticles. Acc. Chem. Res. 2020, 53, 11, 2546-2557. PDF

130. Wilhelm J, Wang Z, Sumer BD, Gao J. Exploiting nanoscale cooperativity for precision medicine. Adv. Drug Deliv. Rev. 2020, 158, 63-72. PDF

129. Voskuil FJ, Steinkamp PJ, Zhao T, van der Vegt B, Koller M, Doff JJ, Jayalakshmi Y, Hartung JP, Gao J, Sumer BD, Witjes MJH, van Dam GM, & the SHINE study group. Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery. Nat. Comm. 2020, 11, 3257. PDF

128. Huang T, Feng Q, Wang, Z, Li W, Sun Z, Wilhelm J, Huang G, Vo T, Sumer BD, Gao J. Tumor-Targeted Inhibition of Monocarboxylate Transporter 1 Improves T-Cell Immunotherapy of Solid Tumors. Adv. Healthcare Mater. 2020, 2000549. PDF

127. Bennett ZT, Feng Q, Bishop JA, Huang G, Sumer BD, Gao J. Detection of Lymph Node Metastases by Ultra-pH-Sensitive Polymeric Nanoparticles. Theranostics. 2020, 10(7), 3340-3350.  PDF

126. Kong C, Li Y, Liu Z, Ye J, Wang Z, Zhang L, Kong W, Liu H, Liu C, Pang H, Hu Z, Gao J, Qian F. Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release. ACS Nano. 2019, 34, 4, 4049-4063. PDF

125. Huang G, Zhao T, Wang C, Nham K, Xiong Y, Gao X, Wang Y, Hao G, Ge W, Sun X, Sumer BD, Gao J. PET imaging of occult tumors by temporal integration of tumor-acidosis signals from pH-sensitive 64CU-labelled polymers. Nature Biomed. Eng. 2019, 4, 314-324. PDF

124. Feng Q, Wilhelm J, Gao J. Transistor-like Ultra-pH-Sensitive Polymeric Nanoparticles. Acc. Chem. Res. 2019, 52, 6, 1485-1495. PDF

123. Luo M, Liu Z, Zhang X, Han C, Samandi L, Dong C, Sumer BD, Lea J, Fu Y, Gao J. Synergistic STING activation by PC7A nanovaccine and ionizing radiation improves cancer immunotherapy. J. Controlled Release. 2019, 300, 154-160. PDF

122. Li Y, Wang Y, Huang G, Gao J. Cooperativity Principles in Self-Assembled Nanomedicine. Chem. Rev. 2018, 118, 11, 5359-5391. PDF

121. Wang C, Niederstrasser H, Li Y, Olswald N, Lin R, Jaramillo J, Douglas P, MacMillan E, Wang Z, Brekken R, Posner BA, MacMillan JB, Hang G, Gao J, White MA. Small-molecular TFEB pathway agonists ameliorate metabolic syndrome and modulate life-span. Nat. Comm. 2018, 8, 2270. PDF

120. Aroh C, Wang Z, Dobbs N, Luo M, Chen Z, Gao J, Yan N. Innate immune activation by cGAMP-PC7A nanoparticles leads to potent and long-acting antiretroviral response against HIV-1. J. Immunol. 2017, 199, 3840-3848. PDF

119. Luo M, Samandi LZ, Wang Z, Chen ZJ, Gao J. Synthetic nanovaccines for immunotherapy. J. Controlled Release. 2017, 263, 200-210. PDF

118. Luo M, Wang H, Wang Z, Cai H, Lu Z, Li Y, Du M, Huang G, Wang C, Chen X, Porembka MR, Lea J, Frankel AE, Fu Y, Chen ZJ, Gao J. A STING-activating nanovaccine for cancer immunotherapy. Nature Nanotech. 2017, 12, 648-654. PDF

117. Wang Y, Wang C, Li Y, Huang G, Zhao T, Ma X, Wang Z, Sumer BD, White MA, Gao J. Digitization of Endocytic pH by Hybrid Ultra-pH-Sensitive Nanoprobes at Single-Organelle Resolution. Adv. Mater. 2017, 29, 1603794. PDF

116. Wang Z, Luo M, Mao C, Wei Q, Zhao T, Li Y, Huang G, Gao, J. A Redox-Activatable Fluorescent Sensor for the High-Throughput Quantification of Cytosolic Delivery of Macromolecules. Angew. Chem. Int. Ed. 2017, 56, 1319-1323. PDF

115. Zhao T, Huang G, Li Y, Yang S, Ramazani S, Lin Z, Wang Y, Ma X, Zeng Z, Luo M, De Boer E, Sun X, Thibodeaux J, Brekken RA, Sun X, Sumer BD, Gao J. A transistor-like pH nanoprobe for tumour detection and image-guided surgery. Nature Biomed. Eng. 2016, 1, 0006. PDF

114. Li Y, Zhao T, Wang C, Lin Z, Huang G, Sumer BD, Gao J. Molecular basis of cooperativity in pH-triggered supramolecular self-assembly. Nature Comm. 2016, 7, 13214. PDF

113. Li Y, Wang Z, Wei Q, Luo M, Huang G, Sumer BD, Gao J. Non-covalent interactions in controlling pH-responsive behaviors of self-assembled nanosystems. Polym. Chem. 2016, 7, 5949-5956. PDF

112. Wang C, Zhao T, Li Y, Huang G, White MA, Gao J. Investigation of Endosome and Lysosome Biology by Ultra pH-Sensitive Nanoprobes. Adv. Drug. Deliver. Rev. 2017, 113, 87-96. PDF

111. Ma X, Moore Z, Huang G, Huang X, Boothman DA, Gao, J. Nanotechnology-enabled delivery of NQO1 bioactivatable drugs. J. Drug Target. 2015, 7-8, 672-680. PDF

110. Zhang L, Chen Z, Yang K, Liu C, Gao J, Qian F. β-Lapachone and Paclitaxel Combination Micelles with Improved Drug Encapsulation and Therapeutic Synergy as Novel Nanotherapeutics for NQO1-Targeted Cancer Therapy. Mol. Pharm. 2015, 12, 3999-4010. PDF

109. Wang C, Wang Y, Li Y, Bodemann B, Zhao T, Ma X, Huang G, Hu Z, DeBerardinis RJ, White MA, Gao, J. A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles. Nature Comm. 2015, 6, 8524. PDF

108. Ma X, Huang X, Moore Z, Huang G, Kilgore JA, Wang Y, Hammer S, Williams NS, Boothman DA, Gao, J. Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy. J. Controlled. Release. 2015, 200, 201-211PDF

107. Ma X, Wang Y, Zhao T, Li Y, Su L, Wang Z, Huang G, Sumer BD, Gao J. Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions. J. Am. Chem. Soc. 2014, 136, 11085-11092. PDF

106. Li Y, Wang Y, Huang G, Ma X, Zhou K, Gao J. Chaotropic-Anion-Induced Supramolecular Self-Assembly of Ionic Polymeric Micelles. Angew. Chem. Int. Ed. 2014, 53, 8074-8078. PDF

105. Morales, JC, Li L, Fattah FJ, Dong Y, Bey EA, Patel M, Gao J, Boothman DA Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases. Crit. Rev. Eukaryot. Gene Expr. 2014, 24, 15-28. PDF

104. Ma X, Huang X, Huang G, Li L, Wang Y, Luo X, Boothman DA, Gao J. Prodrug Strategy to Achieve Lyophilizable, High Drug Loading Micelle Formulations Through Diester Derivatives of β-Lapachone. Adv. Healthc. Mater. 2014, 3, 1210-1216. PDF

103. Sun JY, Shen J, Thibodeaux J, Huang G, Wang Y, Gao J, Low PS, Dimitrov DS, Sumer BD, In Vivo optical imaging of folate receptor-β in Head and Neck squamous cell carcinoma. Laryngoscope. 2014, 124, E312-319. PDF

102. Wang Y, Zhou K, Huang G, Hensley C, Huang X, Ma X, Zhao T, Sumer BD, DeBerardinis RJ, Gao J. A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals. Nat. Mater. 2014, 13, 204-212PDF

101. Zhou H, Stafford JH, Hallac RR, Zhang L, Huang G, Mason RP, Gao J, Thorpe PE, Zhao D. Phosphatidylserine-Targeted Molecular Imaging of Tumor Vasculature by Magnetic Resonance Imaging. J. Biomed. Nanotechnol. 2013, 10, 846-855. PDF

100. Bey EA, Reinicke KE, Srougi MC, Varnes M, Anderson VE, Pink JJ, Li LS, Patel M, Cao L, Moore Z, Rommel A, Boatman M, Lewis C, Euhus DM, Bornmann WG, Buchsbaum DJ, Spitz DR, Gao J, Boothman DA. Catalase Abrogates β-Lapachone-Induced PARP1 Hyperactivation-Directed Programmed Necrosis in NQO1-Positive Breast Cancers. Mol. Cancer Ther. 2013, 12, 2110-2120 PDF

99. Togao O, Kessinger CW, Huang G, Soesbe TC, Sagiyama K, Dimitrov AI, Sherry DA, Gao J, Takahashi M. Characterization of Lung Cancer by Amide Proton Transfer (APT) Imaging: An In-Vivo Study in an Orthotopic Mouse Model. PLoS ONE. 2013, 8(10): e77019 PDF

98. Regonda S, Tian R, Gao J, Greene S, Ding J, Hu W. Silicon multi-nanochannel FETs to improve device uniformity/stability and femtomolar detection of insulin in serum. Biosens. Bioelectron., 2013, 45, 245–251. PDF

97. Huang X, Huang G, Zhang S, Sagiyama K, Togao O, Ma X, Wang Y, Li Y, Soesbe TC, Sumer BD, Takahashi M, Sherry AD, Gao J. Multi-Chromatic pH-Activatable 19F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical-Shift Barcodes. Angew. Chem. Int. Ed. 2013, 52, 8074-8078. PDF

96. Zhang S, Zhou K, Huang G, Takahashi M, Sherry AD, Gao J. A Novel Class of Polymeric pH-Responsive MRI CEST Agents. Chem. Comm. 2013, 49, 6418-6420. PDF

95. Huang G, Chen H, Dong Y, Luo X, Yu H, Moore Z, Bey EA, Boothman DA, Gao J. Superparamagnetic Iron Oxide Nanoparticles: Amplifying ROS Stress to Improve Anticancer Drug Efficacy. Theranostics 2013, 3, 116-126. (Article was picked for the journal cover). PDF

94. Zheng N, Dai W, Du W, Zhang H, Lei L, Zhang H, Wang X, Wang J, Zhang X, Gao J, Zhang Q. A novel lanreotide-encoded micelle system targets paclitaxel to the tumors with overexpression of somatostatin receptors. Mol. Pharm. 2012, 9, 1175-88. PDF

93. Huang X, Dong Y, Bey EA, Kilgore JA, Bair JS, Li LS, Patel M, Parkinson EI, Wang Y, Williams NS, Gao J, Hergenrother PJ, Boothman DA. An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis. Cancer Res. 2012, 72, 3038–47. PDF

92. Zhou K, Liu H, Zhang S, Huang X, Wang Y, Huang G, Sumer BD, Gao J. Multicolored pH-Tunable and Activatable Fluorescence Nanoplatform Responsive to Physiologic pH Stimuli. J Am Chem Soc, 2012, 134, 7803-7811. PDF

91. Yu H, Zou Y, Wang Y, Huang XN, Huang G, Sumer BD, Boothman DA, Gao J. Overcoming Endosomal Barrier by Amphotericin B-loaded Dual pH-Responsive PDMA-b-PDPA Micelleplexes for siRNA Delivery. ACS Nano, 2011, 5, 9246-55. PDF

90. Ding H, Yu H, Dong Y, Tian R, Huang G, Boothman DA, Sumer BD, Gao J. Photoactivation Switch from Type II to Type I Reactions by Electron-Rich Micelles for Improved Photodynamic Therapy of Cancer Cells Under Hypoxia. J. Controlled Release. 2011, 156, 276-80. PDF

89. Ding H, Sumer BD, Kessinger CW, Dong Y, Huang G, Boothman DA, Gao J. Nanoscopic Micelle Delivery Improves the Photophysical Properties and Efficacy of Photodynamic Therapy of Protoporphyrin IX. J. Controlled Release. 2011, 151, 271-277. PDF

88. Tian R, Regonda R, Gao J, Hu W. Reliable multi-Si-nanowires FETs for ultrasensitive protein detection at sub-femtomolar levels. Lab on a Chip. 2011, 11, 1952-1961. PDF

87. Zhou K, Wang Y, Huang X, Luby-Phelps K, Sumer BD, Gao J. Tunable, Ultrasensitive pH-Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells. Angew. Chem. Int. Ed., 2011, 50, 6109-6114. PDF

86. Kessinger CW, Togao O, Khemtong C, Huang G, Takahashi M, Gao J. Investigation of In Vivo Targeting Kinetics of αvβ3-Specific Superpara-magnetic Nanoprobes by Time-Resolved MRI. Theranostics, 2011, 1, 263-275. PDF

85. Khemtong C, Togao O, Ren J, Kessinger CW, Takahashi M, Sherry AD, Gao J. Off-Resonance Saturation MRI of Superparamagnetic Nanoprobes: Theoretical Models and Experimental Validations. J. Mag. Res., 2011, 209, 53-60. PDF

84. Li LS, Bey EA, Dong Y, Meng J, Patra B, Yan J, Xie XJ, Brekkend RA, Barnett C, Bornmann WG, Gao J, Boothman DA. Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of beta-lapachone for pancreatic cancer therapy. Clin. Cancer Res., 2011, 17, 275-85. PDF

83. Tao L, Hu W, Liu Y, Huang G, Sumer BD, Gao J. Shape-specific Polymeric Nanomedicine: Emerging Opportunities and Challenges. Exp. Biol. Med., 2011, 236, 20-29. PDF

82. Dong Y, Bey E, Li LS, Kabbani W, Yan J, Xie XJ, Hsieh JT, Gao J. Boothman, Prostate Cancer Radiosensitization through poly(ADP-ribose) polymerase-1 hyperactivation. Cancer Res. 2010, 70, 8088-8096. PDF

81. Shah S, Liu L, Hu H, Gao J. Modeling Particle Shape-Dependent Dynamics in Nanomedicine. J. Nanotech. Nanosci., 2010, 11, 919-928. PDF

80. Tao L, Zhao XM, Gao J, Hu W. Lithographically Defined Uniform Worm-shaped Polymeric Nanoparticles. Nanotechnology, 2010, 21, 1-6. PDF

79. Chen H, Khemtong C, Yang X, Gao J. Nanonization Strategies for Poorly Water-Soluble Drugs. Drug Discovery Today. 2011, 16, 354-360. PDF

78. Tian R, Seitz O, Li M, Hu W, Chabal Y, Gao J. Infrared Characterization of Interfacial Si-O-Si Bond Formation on Silanized SiO2 Surfaces. Langmuir, 2010, 26, 4563-4566. PDF

77. Kessinger C, Khemtong C, Togao O, Takahashi M, Sumer BD, Gao J. In Vivo Angiogenesis Imaging of Solid Tumors by alphavbeta3-Targeted, Dual-Modality Micellar Nanoprobes. Exp. Bio. Med. 2010, 235, 957-965. PDF

76. Cohen E, Kessinger CK, Khemtong C, Gao J, Sumer B. Polymeric micelle nanoparticles for photodynamic treatment of head and neck cancer cells. Otolaryngol. Head Neck Surg., 2010, 143, 109-115. (Article was picked for the journal cover). PDF

75. Blanco E, Bey EA, Khemtong C, Yang SG, Setti-Guthi J, Kessinger C, Bornmann WG, Boothman DA, Gao J. β-Lapachone Micelle Nanotherapeutics for Lung Cancer Treatment. Cancer Res., 2010, 70, 3896-3904. PDF

74. Setti Guthi J, Yang SG, Huang G, Li S, Khemtong C, Kessinger CW, Peyton M, Minna JD, Brown KC, Gao J. MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells. Mol. Pharm. 2010, 7, 32-40. PDF

73. Huang G, Zhang C, Li S, Khemtong C, Yang S, Tian R, Minna JD, Brown KC, Gao, J. A Novel Strategy for Surface Modification of Superparamagnetic Iron Oxide Nanoparticles for Lung Cancer Imaging. J. Mater. Chem., 2009, 19, 6367- 6372. PDF

72. Buyukserin F, Aryal M, Gao J, Hu WH. High Throughput Fabrication of Polymeric Composite Nanorods Using Bilayer Nanoimprint Lithography, Small, 2009, 5, 1632-1636. PDF

71. Khemtong C, Kessinger C, Gao J. Polymeric Nanomedicine for Cancer MR Imaging and Drug Delivery. Chem. Comm. 2009, 3497-3510. (Article was picked for the journal cover). PDF

70. Chen GH, Chen W, Wu Z, Yuan R, Li H, Gao J, Shuai XT. MRI-visible polymeric vector bearing CD3 single chain antibody mediated highly efficient gene delivery to T cells for immunosuppression. Biomaterials, 2009, 30, 1962-1970. PDF

69. Khemtong C, Kessinger CW, Ren J, Bey E, Yang SG, Guthi J, Boothman DA, Sherry AD, Gao J. In Vivo Off Resonance Saturation Magnetic Resonance Imaging of avb3-Targeted Superparamagnetic Nanoparticles. Cancer Res. 2009, 69, 1651-1658. (Article was picked for the journal cover). PDF

68. Blanco E, Kessinger C, Sumer B, Gao J. Multifunctional Micellar Nanomedicine for Cancer Therapy. Exp. Biol. Med. 2009, 234, 123-131. PDF

67. Dong Y, Chin SF, Blanco E, Bey EA, Kabbani W, Xie XJ, Bornmann WG, Boothman DA, Gao J. Intratumoral Delivery of β-Lapachone via Polymer Implants for Prostate Cancer Therapy. Clin. Cancer Res. 2009, 15, 131-139. PDF

66. Sumer BD, Gao J. Theranostic Nanomedicine for Cancer. Nanomedicine, 2008, 3, 137-140. PDF

65. Aryal M, Buyukserin F, Mielczarek K, Zhao XM, Gao J, Zakhidov A, Hu W. Imprinted large-scale high density polymer nanopillars for organic solar cells. J. Vac. Sci. Tech. B, 2008, 26, 2562-2566. PDF

64. Yang X, Deng W, Fu L, Gao J, Quan, D, Shuai X. Folate-Functionalized Polymeric Micelles for Tumor Targeted Delivery of a Potent Multidrug-resistance Modulator FG020326. J. Biomed. Mat. Res. 2008, 86, 48-60. PDF

63. Yang X, Chen Y, Yuan R, Chen G, Blanco E, Gao J, She X. Folate-Encoded and Fe3O4-Loaded Polymeric Micelles for Dual Targeting of Cancer Cells. Polymer 2008, 49, 3477-3485. PDF

62. Barcena C, Sra AK, Chaubey GS, Khemtong C, Liu JP, Gao J. Zinc Ferrite Nanoparticles as MRI Contrast Agents. Chem. Comm. 2008, 2224-2226. PDF

61. Weinberg B, Blanco E, Gao J. Polymer Implants for Intratumoral Drug Delivery and Cancer Therapy. J. Pharm. Sci. 2008, 97,1681-1702. PDF

60. Tao L, Crouch A, Yoon F, Lee BK, Guthi JS, Kim JY, Gao J, Hu W. Induced patterning of organic and inorganic materials by spatially discrete surface energy. J. Vac. Sci. Tech. B, 2007, 25, 1993-1997. PDF

59. ​Weinberg BD, Patel R, Exner A, Saidel GM, Gao J. Modeling Doxorubicin Transport Properties to Improve Intratumoral Drug Delivery to RF Ablated Tumors. J. Controlled Release, 2007, 124, 11-19PDF

58. Blanco E, Bey EA, Dong Y, Weinberg BD, Sutton DM, Boothman DA, Gao J. Beta-Lapachone-containing PEG-PLA Polymer Micelles as Novel Nanotherapeutics against NQO1-overexpressing Tumor Cells. J. Controlled Release, 2007, 122, 365-374. PDF

57. Bey EA, Bentle MS, Reinicke KE, Dong Y, Yang CR, Girard L, Minna JD, Bornmann WG, Gao J, Boothman DA. A Novel NQO1- and PARP-1-Mediated Cell Death Pathway Induced In Non-Small Cell Lung Cancer Cells By Beta-Lapachone. Proc. Natl. Acad. Sci. USA, 2007, 104, 11832-11837. PDF

56. Sutton D, Wang SH, Nasongkla N, Gao J. Dormidontova, E.E. Doxorubicin and Beta-Lapachone Release and Interaction with Micellar Core Materials: Experiment and Modeling. Exp. Biol. Med. 2007, 232, 1090-1099. PDF

55. Chaubey GS, Barcena C, Poudyal N, Rong C, Gao J, Sun S, Liu JP. Synthesis and Stabilization of FeCo Nanoparticles. J. Am. Chem. Soc. 2007, 129, 7214-7215. PDF

54. Sutton D, Nasongkla N, Blanco E, Gao J. Functionalized Micellar Systems for Cancer Targeted Drug Delivery. Pharm. Res. 2007, 24, 1029-1046. PDF

53. Wang F, Saidel G, Gao J. A Mechanistic Model of Controlled Drug Release from Polymer Millirods: Effects of Excipients and Complex Binding. J. Controlled Release. 2007, 119, 111-120. PDF

52. Weinberg BD, Blanco EB, Lempka SF, Anderson JM, Exner A, Gao J. Combined Radiofrequency Ablation and Doxorubicin-Eluting Polymer Implants for Liver Cancer Treatment. J. Biomed. Mat. Res. 2007, 81, 205-213. PDF

51. Weinberg B, Ai H, Blanco E, Anderson JM, Gao, J. Antitumor Efficacy and Local Distribution of Doxorubicin via Intratumoral Delivery from Polymer Millirods. J. Biomed. Mat. Res. 2007, 81, 161-170. PDF

50. Nasongkla N, Bey E, Ren J, Ai H, Khemtong C, Setti Guthi J, Chin S, Sherry AD, Boothman D, Gao J. Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Deliveryu Systems. Nano Letters. 2006, (6)11, 2427-2430. PDF

49. Bey EA, Wuerzberger-Davis S, Pink J, Yang C, Araki S, Reinicke K, Bentle M, Dong Y, Cataldo E, Criswell T, Wagner M, Li L, Gao J. Boothman, D. A. Feedback Regulation, Restriction Threshold Biology, and Redundancy Govern Molecular Stress Responses. J. Cellular Physiology. 2006, 209, 604-610. PDF

48. Wang F, Blanco E, Ai H, Boothman D, Gao J. Modulating Beta-Lapachone Release from Polymer Millirods through Cyclodextrin Complexation. J. Pharm. Sci. 2006, 95, 1-11. PDF

47. Sutton D, Kim S, Shuai X, Leskov K, Marques J, Williams B, Boothman D, Gao J. Efficient Suppression of Secretory Clusterin Levels By Polymer-siRNA Nanocomplexes Enhances Ionizing Radiation Lethality in Human MCF-7 Breast Cancer Cells. Int. J. Nanomed. 2006, 1, 155-162 PDF

46. Sutton D, Durand R, Shuai XT, Gao J. 999000A Facile Route for a Self-Compatiblized pH Sensitive Drug Delivery Matrix. J. Appl. Polymer Sci. 2006, 100, 89-96. PDF

45. Blanco E, Weinberg B, Stowe N, Anderson JM, Gao J. Local Release of Dexamethasone Prevents Fibrosis in Radiofrequency Ablated Livers. J. Biomed. Mat. Res. 2006, 76,174-182. PDF

44. Ai H, Flask C, Weinberg R, Shuai X, Pagel M, Farrell D, Duerk J, Gao J. Magnetite-Loaded Polymeric Micelles as Novel Magnetic Resonance Probes. Adv. Mater. 2005, 17, 1949-1952. PDF

43. Ai H, Pink J, Shuai X, Boothman D, Gao J. Interactions of Polyelectrolyte Shells with Cells. J. Biomed. Mat. Res. 2005, 73, 303-315. PDF

42. Reinicke KE, Bey EA, Bentle MS, Pink J, Ingalls S, Hoppel C, Burton G, Bornmann W, Gao J. Boothman, D. Development of Beta-Lapachone Prodrugs for Therapy Against Human Cancer Cells with Elevated Levels of NQO1. Clin. Cancer Res. 2005, 11, 3055-3064. PDF

41. Park HJ, Ahn KJ, Ahn SD, Choi E, Lee SW, Williams B, Kim JS, Griffin R, Bey EA, Bornmann WG, Gao J, Park HJ, Boothman DA, Song CW. Susceptibility of cancer cells to Beta-Lapachone is enhanced by ionizing radiation. Int. J. Rad. Onco. Biol. Phys. 2005, 61, 212-219. PDF

40. Ough M, Lewis A, Bey E, Gao J, Ritchie JM, Bornman DA, Boothman DA, Oberley LW, Cullen JJ. Efficacy of Beta-Lapachone in Pancreatic Cancer Treatment: Exploiting the Novel, Therapeutic Target NQO1. Cancer Biology & Therapy, 2004, 4, e54-e61. PDF

39. Szymanski-Exner A, Weinberg B, Stowe N, Gallacher A, Wilson D, Haaga JR, Gao J. Pharmacokinetic Analysis of Local Drug Delivery by Computed Tomography. Acad. Rad. 2004, 11, 1326-1336. PDF

38. Nasongkla, N.; Shuai, X.; Ai, H.; Weinberg, B.D.; Pink, J.; Boothman, D.A.; Gao, J. cRGD-Functionalized Polymer Micelles for Targeted Doxorubicin Delivery. Angew. Chem. Int. Ed. 2004, 43, 6323-6327. PDF

37. Shuai XT, Ai H, Nasongkla N, Kim, S, Gao J. Micellar Carriers Based on Block Copolymers of Poly(epsilon-caprolactone) and Poly(ethylene glycol) for Doxorubicin Delivery. J. Controlled Release. 2004, 98, 415-426. PDF

36. Blanco E, Qiang F, Weinberg B, Stowe N, Anderson JM, Gao J. Effect of Fibrous Capsule Formation on Doxorubicin Distribution in Radiofrequency Ablated Rat Livers. J. Biomed. Mat. Res. 2004, 69, 398-406. PDF

35. Qian F, Stowe N, Saidel GM, Gao J. Pharmacokinetic Comparison of Sustained and Dual-Release Polymer Millirods in RF Ablated Livers. Pharm. Res. 2004, 21, 394-399. PDF

34. Ai H, Gao J. Size-Controlled Polyelectrolyte Nanocapsules via Layer-by-Layer Self-Assembly. J. Mater. Sci. 2004, 39, 1429-1432. PDF

33. Szymanski-Exner A, Gallacher A, Stowe N, Weinberg B, Haaga J, Gao J. Local Carboplatin Delivery and Tissue Distribution in Livers Following Radiofrequency (RF) Ablation. J. Biomed. Mat. Res. 2003, 67, 510-516. PDF

32. Nasongkla N, Wiedmann A, Bruening A, Beman M, Ray D, Bornmann WG, Boothman D, Gao J. Enhancement of Solubility and Bioavailability of Beta-Lapachone using Cyclodextrin Inclusion Complexes. Pharm. Res. 2003, 20, 1626-1633. PDF

31. Qian F, Stowe N, Liu EH, Saidel GM, Gao J. Quantification of In Vivo Doxorubicin Transport from PLGA Millirods in Thermoablated Rat Livers. J. Controlled Release, 2003, 91, 157-166. PDF

30. Szymanski-Exner A, Stowe N, Lazebnik R, Salem K, Haaga J, Wilson D, Gao J. Noninvasive Monitoring of Local Drug Release Using X-Ray Computed Tomography: Optimization and In Vitro/In Vivo Validation. J. Pharm. Sci. 2003, 92, 289-296. PDF

29. Salem K, Szymanski-Exner A, Lazebnik R, Breen M, Gao J, Wilson D. X-Ray Computed Tomography Methods for In Vivo Evaluation of Local Drug Release Systems. IEEE-Trans. Med. Imaging, 2002, 21, 1310-1316. PDF

28. Qian F, Saidel G, Sutton D, Szymanski A, Gao J. Combined Modeling and Experimental Approach for The Development of Dual-Release Polymer Millirods. J. Controlled Release 2002, 83, 427-435. PDF

27. Szymanski-Exner A, Stowe N, Lazebnik R, Salem K, Wilson D, Haaga J, Gao J. Noninvasive Monitoring of Local Drug Release in A Rabbit Radiofrequency (RF) Ablation Model Using X-Ray Computed Tomography. J. Controlled Release 2002, 83, 415-425. PDF

26. Gao J, Qian F, Szymanski-Exner A, Stowe N, Haaga J. In Vivo Drug Distribution Dynamics in Thermoablated and Normal Rabbit Livers from Biodegradable Polymers. J. Biomed. Mat. Res. 2002, 62, 308-314. PDF

25. Qian F, Nasongkla N, Gao J. Membrane-encased Polymer Millirods for Sustained Release of 5-Fluorouracil. J. Biomed. Mat. Res. 2002, 61, 203-211. PDF

24. Qian F, Szymanski A, Gao J. Fabrication and Characterization of Controlled Release Poly(D, L-Lactide-co-Glycolide) Millirods. J. Biomed. Mat. Res. 2001, 55, 512-522. PDF

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Professor Gao's publications from his postdoctoral years with Prof. Robert Langer at MIT

23. Niklason LE, Abbott W, Gao J, Klagges B, Hirschi KK, Ulubayram K, Conroy N, Jones R, Vasanawala A, Sanzgiri S, Langer R. Morphologic and Mechanical Characteristics of Engineered Bovine Arteries. J. Vas. Surg. 2001, 33, 628-638PDF

22. Niklason L, Gao J, Abbott W, Hirschi K, Houser S, Marini R, Langer R. Functional Arteries Grown In Vitro. Science 1999, 284, 489-493. PDF

21. Gao J, Niklason L, Langer RS. Surface Hydrolysis of Poly(glycolic acid) Meshes Increases the Seeding Density of Vascular Smooth Muscle Cells. J. Biomed. Mater. Res. 1998, 42, 417-424. PDF

20. Gao J, Niklason L, Zhao X, Langer RS. Surface Modification of Polyanhydride Microspheres. J. Pharm. Sci. 1998, 87, 246-248. PDF

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Professor Gao's Publications from his graduate school years working with Prof. George Whitesides at Harvard University

19. Gao J, Wu Q, Carbeck J, Lei QP, Smith RD, Whitesides GM. Probing the Energetics of Dissociation of Carbonic Anhydrase-Ligand Complexes in the Gas Phase. Biophys J. 1999, 76, 3253-3260. PDF

18. Carbeck J, Severs J, Gao J, Wu Q, Smith RD, Whitesides GM. Correlation between the Charge of Proteins in Solution and in the Gas Phase Investigated by Protein Charge Ladders, Capillary Electrophoresis, and Electrospray Ionization Mass Spectrometry. J. Phys. Chem. B 1999, 102, 10596-10601. PDF

17. Carbeck J, Colton I, Gao J, Whitesides GM. Protein Charge Ladders, Capillary Electrophoresis, and the Role of Electrostatics in Biomolecular Recognition. Acc. Chem. Res. 1998, 31, 343-350. PDF

16. Colton I, Anderson J, Gao J, Chapman R, Isaacs L, Whitesides GM. Formation of Protein Charge Ladders by Acylation of Amino Groups on Proteins. J. Am. Chem. Soc. 1997, 119, 12701-12709. PDF

15. Córdova E, Gao J, Whitesides GM. Non-Covalent Polycationic Coatings for Capillaries in Capillary Electrophoresis of Proteins. Anal. Chem. 1997, 69, 1370-1379. PDF

14. Gao J, Whitesides GM. Using Protein Charge Ladders to Determine the Values of Effective Charge and Molecular Weight of Proteins. Anal. Chem. 1997, 69, 575-580. PDF

13. Wu Q, Gao J, Joseph-McCarthy D, Sigal GB, Bruce JE, Whitesides GM, Smith RD. Carbonic Anhydrase-Inhibitor Binding: From Solution to the Gas Phase. J. Am. Chem. Soc. 1997, 119, 1157-1158. PDF

12. Gao J, Martichonok V, Whitesides GM. Synthesis of a Phosphonate Analog of Sialic Acid (Neu5Ac) Using Indium-Mediated Allylation of Unprotected Carbohydrates in Aqueous Media. J. Org. Chem. 1996, 61, 9538-9540. PDF

11. Gao J, Cheng X, Chen R, Sigal GB, Bruce JE, Schwartz BL, Hofstadler SA, Anderson GA, Smith RD, Whitesides GM. Screening Derivatized Peptide Libraries for Tight Binding Inhibitors to Carbonic Anhydrase II by Electrospray Ionization-Mass Spectrometry. J. Med. Chem. 1996, 39, 1949-1955. PDF

10. Gao J, Mammen M, Whitesides GM. The Use of Protein Charge Ladders to Evaluate Electrostatic Contributions to Biomolecular Recognition. Science 1996, 272, 535-537. PDF

9. Chu YH, Avila LZ, Gao J, Whitesides GM. Affinity Capillary Electrophoresis. Acc. Chem. Res. 1995, 28, 461-468. PDF

8. Gao J, Mrksich M, Gomez FA, Whitesides GM. Using Capillary Electrophoresis to Follow the Acetylation of the Amino Groups of Insulin and to Estimate their Basicities. Anal. Chem. 1995, 67, 3093-3100. PDF

7. Cheng X, Chen R, Bruce JE, Schwartz BL, Anderson GA, Hofstadler SA, Gale DC, Smith RD, Gao J, Sigal GB, Mammen M, Whitesides GM. Using Electrospray Ionization FTICR Mass Spectrometry to Study Competitive Binding of Inhibitors to Carbonic Anhydrase. J. Am. Chem. Soc. 1995, 117, 8859-8860. PDF

6. Gao J, Qiao S, Whitesides GM. Increasing Binding Constants of Ligands to Carbonic Anhydrase by Using "Greasy Tails." J. Med. Chem. 1995, 38, 2292-2301. PDF

5. Gao J, Gomez FA, Haerter R, Whitesides GM. Determination of the Effective Charge of a Protein in Solution by Capillary Electrophoresis. Proc. Natl. Acad. Sci. USA, 1994, 91, 2027-12030. PDF

4. Gao J, Haerter R, Gordon D, Whitesides GM. Synthesis of KDO Using Indium-Mediated Allylation of 2,3:4,5-Di-O-isopropylidene-D-arabinose in Aqueous Media. J. Org. Chem. 1994, 59, 3714-3715. PDF

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Professor Gao's publications from his undergraduate years with Profs. Biying Zhao and Xianping Xu at Peking University

3. Zhao B, Xu X, Gao J, Fu Q, Tang Y. Structure Characterization of WO3/ZrO2 Catalysts by Raman Spectroscopy. J. Raman Spectrosc. 1996, 27, 549-554. PDF

2. Zhao B, Xu X, Gao J, Ma H, Tang Y. The Effect of the Preparation Method on the Structure of WO3/ZrO2. Acta Phys.-Chim. Sinica, 1995, 11, 982-986.

1. Zhao B, Xu X, Ma H, Gao J, Wang R, Sun D, Tang Y. A New Way to Prepare Catalysts on Solid Support with Highly Specific Surfaces. Acta Phys. -Chim. Sinica, 1993, 9, 8-14.

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