Publications

Selected Publications for Henne lab:

2024

• Ugrankar-Banerjee R, Tran S, Srivastava S, Bowerman J, Paul B, Zacharias LG, Mathews TP, DeBerardinis RJ, Henne WM. Metabolic rewiring in fat-depleted Drosophila reveals triglyceride:glycogen crosstalk and identifies cDIP as a new regulator of energy metabolism. BioRxiv, May 2024.
• Henne WM. Molecular determinants of lipid droplet subpopulations and their fates. FEBS Letters. May 2024.
• Merta H, Isogai T, Paul B, Danuser G, Henne WM. Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration. BioRxiv. Jan 2024.
• Paul B, Merta H, Ugrankar-Banerjee R, Hensley M, Tran S, Dias do Vale G, McDonald JG, Farber SA, Henne WM. Paraoxonase-like APMAP maintains endoplasmic reticulum-associated lipid and lipoprotein homeostasis. BioRxiv, Jan 2024.
• Ortiz Speer N, Braun RJ, Reynolds E, Swanson J, Henne WM. Tld1 is a regulator of triglyceride lipolysis that demarcates a lipid droplet subpopulation. Journal of Cell Biology, Jan 2024.

2023

• Henne WM. The (social) lives, deaths, and biophysical phases of lipid droplets. Current Opinion in Cell Biology. June 2023.
• Ugrankar R, Tran S, Bowerman J, Kovalenko A, Paul B, Henne WM. The fat body cortical actin network regulates Drosophila inter-organ nutrient trafficking, signaling, and adipocyte cell size. ELife, May 2023.
• Ortiz Speer N, Braun RJ, Reynolds E, Swanson J, Henne WM. Bsc2 is a novel regulator of triglyceride lipolysis that demarcates a lipid droplet subpopulation. BioRxiv, Mar 2023.

2022

• Rogers S, Long G, Kovalenko A, Zoni V,...Thiam AR, Vanni S, Nicastro D, Henne WM. Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome. The Journal of Cell Biology. Nov 2022. See highlight of this work here!
• Ugrankar R, Tran S, Bowerman J, Kovalenko A, Paul B, Henne WM. The fat body cortical actin network regulates Drosophila inter-organ nutrient trafficking and adipocyte cell size. BioRxiv, June 2022.
• Zhou J, Simon JM, Liao C, Zhang C, Hu L, Zurlo G, Liu X, Fan C, Hepperla A, Jia L, Tcheuyap V, Zhong H, Elias R, Ye J, Henne WM, Kapur P, Nijhawan D, Brugarolas J, Zhang Q. An oncogenic JMHD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal carcinoma. Molecular Cell, Aug 2022.
• Zechner C, Henne WM, Sathe AA, Xing C, Hernandez G, Sun S, Cheong MC. Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1 and phosphate uptake are controlled post-transcriptionally by ESCRT. JBC, June 2022.
• Hariri H, Henne WM. Filling in the gaps: SNX-RGS proteins as multiorganelle tethers. The Journal of Cell Biology. May 2, 2022.
• Girik V, Feng S, Hariri H, Henne WM, Riezman H. Vacuole-specific lipid release for tracking intracellular lipid metabolism and transport in Saccharomyces cervisiae. ACS Chemical Biology, Feb 15, 2022.
• Paul B, Weeratunga S, Tillu V, Hariri H, Henne WM, Collins B. Structural predictions of the SNX-RGS proteins suggests they belong to a New Class of Lipid Transfer Proteins. Front Cell Dev Biol, Feb 3, 2022.
• Henne WM. Mapping organelle supply chains. Nature Reviews Molecular Cell Biology. Jan 13, 2022.

2021

• Paul B, Henne WM. How cells flex their PEX to fine-tune lipolysis in NAFLD. Nature Metabolism. Dec 13, 2021.
• Paul B, Weeratunga S, Tillu V, Hariri H, Henne WM, Collins B. Experimental and in silico Alphafold2 derived structures of the SNX-RGS proteins suggest a new class of lipid transfer protein. BioRxiv, Dec 1, 2021.
• Lauzier A, Bossanyi M, Larcher R, Nassari S, Ugrankar R, Henne WM, Jean S. Snazarus and its human ortholog SNX25 regulate autophagic flux by affecting VAMP8 endocytosis. Journal of Cell Science, Nov 25, 2021.
• Gok M, Speer N, Henne WM, Friedman J. ER localized phosphatidylethanolamine synthase plays a conserved role in lipid droplet formation. MBoC, Nov 24, 2021.
• Rogers S, Gui L, Kovalenko A, Reetz E, Nicastro D, Henne WM. Liquid-crystalline lipid phase transitions in lipid droplets selectively remodel the LD proteome. BioRxiv. Aug 31, 2021.
• Henne WM. How the vacuole ESCRTs its own proteins to their final destination. JCB. July 19, 2021. (Spotlight article).
• Rogers S, Hariri H, Wood NE, Speer N, Henne WM. Glucose restriction drives spatial re-organization of mevalonate metabolism. eLife. April 7, 2021. (see ELife highlight article)
• Henne WM. (2021). Organelle homeostasis principles: How organelle quality control and inter-organelle crosstalk promote cell survival. Developmental Cell. (Commentary for special organelle issue), April 5, 2021.
• Henne WM. (2021). How NPC1 Loss Twists the TORCque of Lysosomes. Developmental Cell. (Preview). Feb 8, 2021.
• Rogers S, Henne WM. (2021). Analysis of Neutral Lipid Synthesis in Saccharomyces cervisiae by Metabolic Labeling and Thin Layer Chromatography. JOVE, Feb 2, 2021.

2020

• Datta S, Bowerman J, Hariri H, Ugrankar R, Eckert KM, Corley C, Vale G, McDonald JG, Henne WM. Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease. PNAS, Dec 11, 2020.
• Wood NE, Kosintangool P, Hariri H, Marchland A, Henne WM. Nutrient signaling, stress response, and interorganelle communication are non-canonical determinants of cell fate. Cell Reports, Dec 1, 2020.
• Bryant D, Seda M, Peskett E, Maurer C, Pomeranz G, Ghosh M, Hawkins T, Cleak J, Datta S, Hariri H, Eckert K, Jafree D, Walsh C, Demetriou C, Ishida M, Alemán‑Charlet C, Vestito L, Seselgyte R, McDonald J, Bitner‑Glindzicz M, Hemberger M, Rihel J, Teboul L, Henne WM, Jenkins D, Moore G & Stanier P. (2020). Diverse species‑specific phenotypic consequences of loss of function sorting nexin 14 mutations. Scientific Reports, 10 13763. doi.org/10.1038/s41598-020-70797-2

2019   

•  Ugrankar R, Bowerman J, Hariri H, Chandra M, Chen K, Bossanyi M, Datta S, Rogers S, Eckert K, Vale G, Victoria A, Fresquez J, McDonald J, Jean S, Collins B, Henne WM. Drosophila Snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes. Developmental Cell. Aug 6; pii: S1534-5807(19)30627-6. (see highlight in Science Signaling)
•  Henne WM, Goodman J, Hariri H*. Spatial compartmentalization of lipid droplet biogenesis. BBA Mol Cell Biol Lipids. Jul 25, 2019.
•  Henne WM. Spastin joins LDs and peroxisomes in the interorganelle contact ballet. The Journal of Cell Biology. July 5;2019.
•  Datta S, Liu Y, Hariri H, Henne WM. Cerebellar ataxia disease-associated Snx14 promotes lipid droplet growth at ER-droplet contacts. The Journal of Cell Biology, Apr1; 218(4):1335. (see Spotlight in JCB)
•  Hariri H, Speer N, Bowerman J, Datta S, Ugrankar R, Henne WM. Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating droplet biogenesis. The Journal of Cell Biology. Apr 1; 218(4):1319. (see Dispatch in Current Biology)
•  Chandra M, Chin YK, Mas C, Feathers R, Paul B, Datta S…Henne WM, Medhi M, Collin BM. Classification of human the human phox homology (PX) domains based on their phosphoinositide binding specificities. Nature Communications, Apr 4; (10):1528.
•  Henne WM. And three's a party: Lysosomes, lipid droplets, and the ER in lipid trafficking and cell homeostasis. Current Opinion in Cell Biology. Apr 16; 59:40-49.

 2018

• Henne WM, Reese M, Goodman J. (2018).  The assembly of lipid droplets and their roles in challenged cells. EMBO J. May 22. e98947.
• Henne WM, Hariri H. (2018). Endoplasmic Reticulum-Vacuole Contact Sites "Bloom" with Stress-Induced Lipid Droplets. CONTACT. Apr3;(1).
• Bryant D*, Liu Y*, Datta S, Hariri H, Seda M, Anderson G, Peskett E, Demetriou C, Sousa S, Jenkins D, Clayton P, Bitner-Glindzicz M, Moore G, Henne WM^, Stanier P^. (2018) SNX14 mutations affect endoplasmic reticulum associated neutral lipid metabolism in autosomal recessive spinocerebellar ataxia 20. Human Molecular Genetics. Apr. 9 (*:co-first authors; ^: co-corresponding authors)
• Ugrankar R, Theodoropoulos P, Akdemir F, Henne WM, Graff JM. (2018). Circulating glucose levels inversely correlate with Drosophila larval feeding behavior. Communications Biology, Aug 13, 2018.
• Ferguson S, Henne WM. (2018). Organelles in Metabolism and Stress Responses. Mol. Biol. Cell. Mar 15;29;(6):691.

 2017

• Hariri H, Rogers S, Ugrankar R, Liu Y, Feathers R, WM Henne. (2017) Lipid Droplet Biogenesis is Spatially Coordinated at Yeast ER-Vacuole Contact Sites in Response to Nutritional Stress. EMBO Reports. Nov 16; 2017.
• Henne WM. Discovery and roles of ER-endolysosomal contact sites in disease. (book chapter in book: Organelle Contact Sites: From Molecular Mechanism to Disease. In Tayaga M, Simmens T (eds) Organelle Contact Sites. Advances in Experimental Biology and Medicine. vol 997. Springer Press.

2016

• Henne WM. (2016). Organelle remodeling at membrane contact sites. Journal of Structural Biology, Oct 16, 2016.
• Hariri H, Ugrankar R, Liu Y, Henne WM. (2016). Inter-organelle ER-endolysosomal contact sites in metabolism and disease across evolution. Comm. & Integ. Biol. Apr 9;3 pii:e1156278.
• Tang S, Buchkovich NJ, Henne WM, Banjade S, Kim YJ, Emr SD. (2016). ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis. ELife. Apr13;5 pii:e15507.

 2015

• Tang S, Henne WM, Borbat PP, Buchkovich NJ, Freed JH, Mao Y, Fromme JC, Emr SD. (2015). Structural basis for activation, assembly, and membrane binding of ESCRT-III Snf7 filaments. ELife. Dec 15; 4. pii:e12548.
• Henne WM, Zhu,L, Balogi Z, Stefan C, Pleiss J, Emr SD. (2015).  Mdm1/Snx13 is a novel ER-endolysosomal inter-organelle tethering protein.  J Cell Biol. Aug. 17;210(4):541-551. (see Spotlight in JCB )
• Henne WM, Liou J, Emr SD. (2015).  Molecular mechanisms of inter-organelle ER-PM contact sites. Curr Opin Cell Biol. May 26;35:123-130.

 2014 and before

• Henne WM, Stenmark H, Emr SD. (2013). Molecular mechanisms of the membrane sculpting ESCRT pathway. Cold Springs Harb Perspect Biol. Sept 1;5(9).
• Buchovich N, Henne WM, Tang S, Emr SD. (2013). Essential N-terminal insertion motif anchors the ESCRT-III filament during MVB vesicle formation. 
Dev. Cell. Oct. 28; 27(2):201-214.
• Henne WM, Buchkovich N, Zhao Y, Emr SD. (2012). The endosomal sorting complex ESCRT-II coordinates the assembly and architecture of ESCRT-III helices. 
Cell. Oct 12; 151(2):356-71.
• Henne WM, Buchkovich N, Emr SD. (2011). The ESCRT Pathway. 
Dev. Cell. July 19;21(1):77-91. Review.
• Henne WM, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT. (2010). FCHo proteins are nucleators of clathrin-mediated endocytosis. 
Science. Jun 4;328(5983):1281-4.
• Henne WM, Kent HM, Ford MG, Hegde BG, Daumke O, Butler PJ, Mittal R, Langen R, Evans PR, McMahon HT. (2007). Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature. 
Structure. Jul;15(7):839-52.