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Mechanisms and pathology of protein misfolding and aggregation.
Louros N, Schymkowitz J, Rousseau F. Nature Rev. Mol. Cell Biol. 24(12): 912-933. (2023)
Medin promotes vascular amyloid-β aggregation in Alzheimer’s disease.
Wagner J, Degenhardt K, Veit M, Louros N, et al. Nature 612, 123-131.
(2022)
Louros N, et al. Nature Communications 13, 1351 (2022)
#van der Kant R, #Louros N, et al. Structure 30(8): 1178-89 #equal contribution (2022)
Louros N, et al. Nature Communications 11, 3314. (2020)
Libé-Philippot B, Lejeune A, Wierda K, Louros N, et al. Cell 186(26): 5766-5783 (2023)
Louros N, Rousseau F, Schymkowitz J. Bioinformatics, btae279. (2024)
https://doi.org/10.1093/bioinformatics/btae279
Single-cell infrared absorption spectroscopy of bacterial inclusion bodies.
Duverger W, Tsaka G, Khodoparast L, Khodoparast L, Louros N, Rousseau F, Schymkowitz J. (2024) doi: https://doi.org/10.21203/rs.3.rs-4094624/v1
Local structural preferences in shaping tau amyloid polymorphism.
Louros N, Wilkinson M, Tsaka G, Ramakers M, Morelli C, Garcia T, Gallardo R, D’Haeyer S, Goossens V, Audenaert D, Thal D, Mackenzie IR, Rademakers R, Ranson N, Radford S, Rousseau F, Schymkowitz J. Nature Commun 15, 1028. (2024)
N-glycosylation as a eukaryotic protective mechanism against protein aggregation.
Duran-Romaña R, Houben B, Louros N, De Vleeschouwer M, Wilson M, Matthijs G, Schymkowitz J, Rousseau F. Science Adv. 10, eadk8173. (2024)
Libé-Philippot B, Lejeune A, Wierda K, Louros N, Erkol E, Vlaeminck I, Beckers S, Gaspariunaite V, Bilheu A, Konstantoulea K, Nyitrai H, Vennekens KM, Vidal N, Bird TW, Soto D, Dennis MY, Rousseau F, Comoletti D, Schymkowitz J, Theys T, de Wit J, Vanderhaeghen P. Cell 186(26): 5766-5783.e25. (2023)
Mechanisms and pathology of protein misfolding and aggregation.
Louros N, Schymkowitz J, Rousseau F. Nature Rev. Mol. Cell Biol. 24(12): 912-933. (2023)
Sønderby T, Louros N, Khodaparast L, Khodaparast L, Madsen D, Olsen W, Nagaraj M, Strømgaard K, Rousseau F, Schymkowitz J, Otzen D. J. Mol. Biol. 435 (11): 168039. (2023)
Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein.
Janssen K, Claes F, Van de Velde D, Wehbi V, Houben B, Lampi Y, Louros N, Nys M, Khodoparast L, Khodoparast L, van der Kant R, Verniers J, Garcia T, Ramakers M, Konstantoulea K, Maragkou K, Musteanu M, Barbacid M, Scorneaux B, Beinaert E, Schymkowitz J, Rousseau F. Proc. Nat. Acad. Sci. USA 120(9):e2214921120. (2023)
Wu G, Khodoparast L, Khodoparast L, De Vleeschouwer M, Louros N, Gallardo R, Yi P, Rousseau F, Schymkowitz J. PLOS ONE 18(3): e0283674. (2023)
Bademosi A, Decet M, Kuenen S, Catalayud C, Swerts J, Gallego S, Schoovaerts N, Louros N, Martin E, Karamanou S, Sibarita J-B, Vints K, Gounko N, Meunier F, Economou A, Versees, W, Rousseau F, Schymkowitz J, Soukup S, Verstreken P. Neuron 119(9): 1402-22. (2023)
Exploiting ligand binding domain dimerization for development of novel androgen receptor inhibitors.
Helsen C, Nguyen TT, Lee XY, Eerlings R, Louros N, Schymkowitz J, Rousseau F, Claessens F, Voet A (2022) Mol. Cancer Ther. 21(12): 1823-34. (2022)
Medin promotes vascular amyloid-β aggregation in Alzheimer’s disease.
Wagner J, Degenhardt K, Veit M, Louros N, Konstantoulea K, Skodras A, Obermüller U, Wild K, Bansal V, Dalmia A, Häsler L, Lambert M, Liu P, Davies H, Madine J, Kronenberg-Versteeg D, Feederle R, Del Turco D, Nilsson P, Lashley T, Deller T, Gearing M, Walker L, Heutink P, Rousseau F, Schymkowitz J, Jucker M, Neher J. Nature 612, 123-131. (2022)
Housmans J, Houben B, Monge-Morera M, Asvestas D, Nguyen H, Tsaka G, Louros N, Carpentier S, Delcour J, Rousseau F, Schymkowitz J. Biomacromolecules, 23(9): 3779-97. (2022)
#van der Kant R, #Louros N, Schymkowitz J, Rousseau F. Structure 30(8): 1178-89 #equal contribution (2022)
StAmP-DB: A platform for structures of polymorphic amyloid fibril cores.
#Louros N, #van der Kant R, Rousseau F, Schymkowitz J. Bioinformatics, 38(9):2636-8. #equal contribution (2022)
Louros N, Ramakers M, Michiels E, Konstantoulea K, Morelli C, Garcia T, Moonen N, D’Haeyer S, Goossens V, Thal D, Audenaert D, Rousseau F, Schymkowitz J. Nature Commun 13, 1351 (2022)
Heterotypic amyloid interactions: clues to polymorphic bias and selective cellular vulnerability?
Louros N, Schymkowitz J, Rousseau F. Curr. Opinion Struct. Biol. 72:176-186. (2021)
Nasi G, Aktipi F, Spatharas P, Louros N, Tsiolaki P, Magafa V, Trougakos I, Iconomidou V. Plants 11(1):9. (2021)
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis.
Rosa N, Ivanova H, Wagner L, Kale J, Lemmens I, Karamanou S, Louros N, Shabardina V, Welkenhuyzen K, La Rovere R, Vandermarliere E, Hamada K, Ando H, Rousseau F, Schymkowitz J, Mikoshiba K, Economou A, Tavernier J, Andrews DW, Parys JB, Yule DI, Bultynck G. Nature Cell Death Differ. 29: 788-805. (2021)
Heterotypic Aβ interactions facilitate amyloid assembly and modify amyloid structure.
Konstantoulea K, Guerreiro P, Ramakers M, Louros N, Aubrey L, Houben B, Michiels E, De Vleeschouwer M, Lampi Y, Ribeiro L, De Wit J, Xue W-F, Rousseau F, Schymkowitz J. EMBO Journal, 41(2):e108591. (2021)
Monge-Morera M, Lambrecht M, Deleu L, Louros N, Rousseau F, Schymkowitz J, Delcour J. ACS Omega 6(3):1823. (2021)
Heterotypic interactions in amyloid function and disease.
#Konstantoulea K, #Louros N, Rousseau F., Schymkowitz J. FEBS J 289: 2025-2046. #equal contribution (2021)
Geeraerts S, Kampen KR, Rinaldi G, Gupta P, Planque M, Louros N, Heylen E, De Cremer K, De Brucker K, Vereecke S, Verbelen B, Vermeersch P, Schymkowitz J, Rousseau F, Cassiman D, Fendt SM, Voet A, Cammue BPA, Thevissen K, De Keersmaecker K. Mol. Cancer Ther. 20(1): 50-63. (2021)
The structural basis for an on-off switch controlling Gβγ-mediated inhibition of TRPM3 channels.
Behrendt M, Gruss F, Enzeroth R, Dembla S, Zhao S, Crassous P-A, Mohr F, Nys M, Louros N, Gallardo R, Zorzini V, Wagner D, Economou A, Rousseau F, Schymkowitz J, Philipp S, Rohacs T, Ulens C, Oberwinkler J. Proc. Natl. Acad. Sci. USA 117(46): 29090-0. (2020)
Processing induced changes in food proteins: amyloid formation during boiling of hen egg white.
Monge-Morera M, Lambrecht M, Deleu L, Gallardo R, Louros N, De Vleeschouwer M, Rousseau F, Schymkowitz J, Delcour J. Biomacromolecules 21(6), 2218-28. (2020)
Louros N, Orlando G, De Vleeschouwer M, Rousseau F, Schymkowitz J. Nature Commun 11, 3314. (2020)
Houben B, Michiels E, Ramakers M, Konstantoulea K, Louros N, Verniers J, De Vleeschouwer M, Chicoria N, Vanpoucke T, Gallardo R, Schymkowitz J, Rousseau F. EMBO Journal, e102864. (2020)
Reverse engineering synthetic antiviral amyloids.
Michiels E, Roose K, Gallardo R, Khodoparast L, Khodoparast L, van der Kant R, Siemons M, Houben B, Ramakers M, Wilkinson H, Guerrero P, Louros N, Kaptein S, Ibañez L, Smet A, Baatsen P, Liu S, Vorberg I, Bormans G, Neyts J, Saelens X, Schymkowitz J, Rousseau F. Nature Commun 11, 2832. (2020)
Thermodynamic and Evolutionary Coupling between the Native and Amyloid State of Globular Proteins.
Langenberg T, Gallardo R, van der Kant R, Louros N, Michiels E, Duran-Romaña R, Houben B, Cassio R, Wilkinson H, Garcia T, Ulens C, Van Durme J, Rousseau F, Schymkowitz J. Cell Reports 31(2), 107512. (2020)
Entropic bristles tune the seeding efficiency of prion-nucleating fragments.
Michiels E, Liu S, Gallardo R, Louros N, Mathelié-Guinlet M, Dufrêne Y, Schymkowitz J, Vorberg I, Rousseau F. Cell Reports 30, 2834-45. (2020)
Claes F, Rudyak S, Laird A, Louros N, Beerten J, Debulpaep M, Van Durme J, De Baets G, Houben B, Ramakers M, Yuan K, Gwee S, Hernandez S, Broersen K, Oliveberg M, Moahamed B, Kirstein J, Robberecht W, Rousseau F, Schymkowitz J. Prot. Eng. Des. and Selection (PEDS). 32(10):443‐457. (2019)
Louros N, Konstantoulea K, De Vleeschouwer M, Ramakers M, Schymkowitz J, Rousseau F. Nucleic Acids Res. 48: D389-93. (2019)
Hidden aggregation hot-spots on human apolipoprotein E: a structural study.
Tsiolaki P, Katsafana A, Baltoumas F, Louros N, Iconomidou V. Inter. J. Mol. Sciences, 20(9): 2274. (2019)
Hexapeptide tandem repeats dictate the formation of silkmoth chorion, a natural protective amyloid.
#Tsiolaki P, #Louros N, Iconomidou V. J. Mol. Biol., 430: 3774-3783. #equal contribution (2018)
Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis.
Khodaparast L, Khodaparast L, Gallardo R, Louros N, Michiels E, Ramakrishnan R, Ramakers M, Claes F, Young L, Shahrooei M, Wilkinson H, Desager M, Mengistu W, Nilsson PR, Hammarström P, Aertsen A, Carpentier S, Van Eldere J, Rousseau F, Schymkowitz J. Nature Commun, 9(1): 866. (2018)
αCGRP, another amyloidogenic member of the CGRP family.
Tsiolaki P, Nasi GI, Baltoumas FA, Louros N, Magafa V, Hamodrakas SJ, Iconomidou VA. J. Struct. Biol., 203(1): 27-36. (2018)
Tracking the amyloidogenic core of IAPP amyloid fibrils: Insights from micro-Raman spectroscopy.
Louros N, Tsiolaki PL, Baltoumas FA, Chryssikos GD, Gionis V, Hamodrakas SJ, Iconomidou VA. J. Struct. Biol., 199(2): 140-152. (2017)
Unraveling the aggregation propensity of human insulin C-peptide.
Tsiolaki P, Louros N, Zompra AA, Hamodrakas SJ, Iconomidou VA. Biopolymers, 108 (2). (2017)
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Exploring amyloidogenicity of Clusterin: a structural and bioinformatics analysis.
Tsiolaki P, Nastou K, Louros N, Hamodrakas S, Iconomidou V. Adv. Exp. Med. and Biol., 989:93-107. (2017)
Intrinsic aggregation propensity of the CsgB nucleator protein is crucial for curli fiber formation.
Louros N, Bolas GM, Tsiolaki PL, Hamodrakas SJ, Iconomidou VA. J. Struct. Biol., 195(2): 179-189. (2016)
Louros N, Chrysina ED, Baltatzis GE, Patsouris ES, Hamodrakas SJ, Iconomidou VA. FEBS Letters, 590: 619–630. (2016)
Louros N, Baltoumas FA, Hamodrakas SJ, Iconomidou VA. J. Comp. Aid Mol. Des., 30(2): 153-164. (2016)
Identification of an amyloid fibril forming segment of human Pmel17 repeat domain (RPT domain).
Louros N and Iconomidou V. Biopolymers, 106(1):133-139. (2016)
Exploring the 'aggregation-prone' core of human Cystatin C: A structural study.
Tsiolaki P, Louros N, Hamodrakas SJ, Iconomidou VA. J. Struct. Biol., 191(3): 272. (2015)
Louros N, Tsiolaki PL, Griffin MD, Howlett GJ, Hamodrakas SJ, Iconomidou VA. Int. J. Biol. Macromol., 79: 711-718. (2015)
Louros N, Tsiolaki P, Zompra A, Pappa E, Magafa V, Pairas G, Cordopatis P, Cheimonidou C, Trougakos I, Iconomidou V, Hamodrakas S. Biopolymers, 104(3): 196–5. (2015)
Structural studies of 'aggregation-prone' peptide-analogues of teleostean egg chorion ZPB proteins.
Louros N, Petronikolou N, Karamanos T, Cordopatis P, Iconomidou VA, Hamodrakas SJ. Biopolymers, 102(6): 427-236. (2014)
Louros N, Iconomidou V, Tsiolaki P, Chrysina E, Baltatzis G, Patsouris E, Hamodrakas S. FEBS Letters, 588:52-7. (2014)
Louros N, Iconomidou V, Giannelou P, Hamodrakas S. PLoS ONE, 8(9): e73258. (2013)
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An ‘aggregation prone’ segments of human amylin (IAPP) and non-amyloidogenic variants.
Louros N, Tsiolaki P, Zompra A, Pappa E, Magafa V, Pairas G, Iconomidou V, Cordopatis P, Hamodrakas S. (2014) J. Pept. Sci. 20: S208-209.
Structural analysis of peptide-analogues of human zona pellucida ZP1 protein with amyloidogenic properties: Insights into mammalian zona pellucida formation.
Louros N, Iconomodou V, Hamodrakas S. (2012) J. Pept. Sci. 18: S168-168.