Welcome to the Louros Lab website!
Integrating molecular biophysics, structural biology, and bioinformatics to investigate protein stability, misfolding and aggregation
The Louros Lab focuses on uncovering the determining molecular forces related to protein folding, stability, and misfolding and understanding their impact on function and disease. Another facet of these important biological questions involves the process of protein self-assembly into ordered amyloid fibrils, which are the main hallmark of major neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.
To do this, we employ a hybrid approach combining molecular biophysics with computational biology, structural biology with molecular and cellular biology, a well as biological engineering.
Lab News Feed
N-glycosylation is a novel aggregation gatekeeper!
Our work on how N-glycosylation has been evolutionarily tuned to protect proteins from aggregation.
Click here to read more in Science Advances!
Can we now selectively excite neurons?
LRRC37B is a human modifier of neuronal excitability. We find that LRRC37B is a receptor for FGF13A, which inhibits voltage-gated sodium channels.
Find out more now in Cell!
Our Nature review on all-things aggregation!
Everything you need to know about mechanisms related to protein misfolding, aggregation, amyloid polymorphism, cross-interactions, and much more!
Read more at Nature Rev Mol Cell Biol!
Local amyloid motifs control tau aggregation and polymorphism!
What controls tau aggregation? We find short sequences shape tau polymorphism linked to AD, PSP, and CBD.
Click here to read more in Nature Communications!
We got the Cover on Structure!
Our work on the thermodynamic analysis of polymorphic amyloid fibril structures has made the cover of the Structure issue!
Click here to read the paper!
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What we do
Find out more about the research performed in our lab?
Do you have interesting ideas you would like to pursue by joining in our group?
Meet our group members
Science is not a one-person job..
Who are we?
Interested in joining our team?
Our tools
Find out more information about software developed by the members of our team.
What about You? Join our Team!
We are newly established at the Center for Alzheimer's and Neurodegenerative Diseases, part of the Peter O'Donnell Jr. Brain Institute at UT Southwestern Medical Center. The Louros lab also holds a secondary affiliation to the Department of Biophysics at UT Southwestern Medical Center.
Our group is growing quickly, and we are currently accepting graduate students and postdoctoral scientists. We welcome qualified applicants from all backgrounds
Postdocs
Please email Dr. Louros with your CV and a brief description of your scientific interests and research goals.
Graduate Students
Potential graduate students at UT Southwestern apply and are accepted via the Graduate School of Biomedical Sciences. Once admitted, they typically take the one-semester Core Course and join individual Ph.D. programs during the second semester.
If you are already a UTSW graduate student and are interested in joining the lab, email Dr. Louros or drop by his office in the Center for Alzheimer's and Neurodegenerative Diseases (NS8.314).
- Do you have expertise that could help us?
- Are you interested in expanding your skillset?
- Are you a motivated and curious researcher with interesting ideas you want to pursue?
Contact Dr. Louros about joining the lab!