Featured Publications
Von Hippel-Lindau protein signalling in clear cell renal cell carcinoma.
Liao C, Hu L, Zhang Q, 2024 May Nat Rev Urol
Hu L, Zhang Y, Guo L, Zhong H, Xie L, Zhou J, Liao C, Yao H, Fang J, Liu H, Zhang C, Zhang H, Zhu X, Luo M, von Kriegsheim A, Li B, Luo W, Zhang X, Chen X, Mendell JT, Xu L, Kapur P, Baldwin AS, Brugarolas J, Zhang Q,
2024 Jan
Mol Cell
Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis.
Zhang C, Yu M, Hepperla AJ, Zhang Z, Raj R, Zhong H, Zhou J, Hu L, Fang J, Liu H, Liang Q, Jia L, Liao C, Xi S, Simon JM, Xu K, Liu Z, Nam Y, Kapur P, Zhang Q, 2024 Apr J Clin Invest 8 134USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer.
Xie H, Zhou J, Liu X, Xu Y, Hepperla AJ, Simon JM, Wang T, Yao H, Liao C, Baldwin AS, Gong K, Zhang Q, 2022 Sep Proc Natl Acad Sci U S A 36 119 e2119854119Histone H3 proline 16 hydroxylation regulates mammalian gene expression.
Liu X, Wang J, Boyer JA, Gong W, Zhao S, Xie L, Wu Q, Zhang C, Jain K, Guo Y, Rodriguez J, Li M, Uryu H, Liao C, Hu L, Zhou J, Shi X, Tsai YH, Yan Q, Luo W, Chen X, Strahl BD, von Kriegsheim A, Zhang Q, Wang GG, Baldwin AS, Zhang Q, 2022 Nov Nat Genet
Zhou J, Simon JM, Liao C, Zhang C, Hu L, Zurlo G, Liu X, Fan C, Hepperla A, Jia L, Tcheuyap VT, Zhong H, Elias R, Ye J, Henne WM, Kapur P, Nijhawan D, Brugarolas J, Zhang Q,
2022 Jun
Mol Cell
ZHX2 promotes HIF1a oncogenic signaling in triple-negative breast cancer.
Fang W, Liao C, Shi R, Simon JM, Ptacek TS, Zurlo G, Ye Y, Han L, Fan C, Bao L, Ortiz CL, Lin HR, Manocha U, Luo W, Kim WY, Yang LW, Zhang Q, 2021 Nov Elife 10
Liao C, Glodowski CR, Fan C, Liu J, Mott KR, Kaushik A, Vu H, Locasale JW, McBrayer SK, DeBerardinis RJ, Perou CM, Zhang Q,
2021 Dec
Cancer Res
Hong K, Hu L, Liu X, Simon JM, Ptacek TS, Zheng X, Liao C, Baldwin AS, Zhang Q,
2020 May
Proc. Natl. Acad. Sci. U.S.A.
Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer.
Liao C, Zhang Y, Fan C, Herring LE, Liu J, Locasale JW, Takada M, Zhou J, Zurlo G, Hu L, Simon JM, Ptacek TS, Andrianov VG, Loza E, Peng Y, Yang H, Perou CM, Zhang Q, 2020 Jul Cancer DiscovGenome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss.
Liu X, Simon JM, Xie H, Hu L, Wang J, Zurlo G, Fan C, Ptacek TS, Herring L, Tan X, Li M, Baldwin AS, Kim WY, Wu T, Kirschner MW, Gong K, Zhang Q, 2020 Jan Mol. Cell
Zurlo G, Liu X, Takada M, Fan C, Simon JM, Ptacek TS, Rodriguez J, von Kriegsheim A, Liu J, Locasale JW, Robinson A, Zhang J, Holler JM, Kim B, Zikánová M, Bierau J, Xie L, Chen X, Li M, Perou CM, Zhang Q,
2019 Nov
Nat Commun
1
10
5177
Hu L, Xie H, Liu X, Potjewyd F, James LI, Wilkerson EM, Herring LE, Xie L, Chen X, Cabrera JC, Hong K, Liao C, Tan X, Baldwin AS, Gong K, Zhang Q,
2019 Dec
Cancer Discov
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.
Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, Lawrence C, Fan J, Geng J, Liu X, Hu L, Wang J, Liao C, Hong K, Zurlo G, Parker JS, Auman JT, Perou CM, Rathmell WK, Kim WY, Kirschner MW, Kaelin WG, Baldwin AS, Zhang Q 2018 07 Science 6399 361 290-295
Takada M, Zhang W, Suzuki A, Kuroda TS, Yu Z, Inuzuka H, Gao D, Wan L, Zhuang M, Hu L, Zhai B, Fry CJ, Bloom K, Li G, Karpen GH, Wei W, Zhang Q
2017 Jul
Cancer Res.
EglN2 associates with the NRF1-PGC1a complex and controls mitochondrial function in breast cancer.
Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang C, Pestell RG, Aird KM, Kaelin WG, Liu XS, Zhang Q 2015 Oct EMBO J.
Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG, Zhang Q
2014 Jul
Genes Dev.
13
28
1429-44
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.
Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW, Boehm JS, Ni M, Geisen C, Root DE, Polyak K, Brown M, Richardson AL, Hahn WC, Kaelin WG, Bommi-Reddy A 2009 Nov Cancer Cell 5 16 413-24
Zhang Q, Thomas SM, Lui VW, Xi S, Siegfried JM, Fan H, Smithgall TE, Mills GB, Grandis JR,
2006 May
Proc. Natl. Acad. Sci. U.S.A.
18
103
6901-6
Zhang Q, Thomas SM, Xi S, Smithgall TE, Siegfried JM, Kamens J, Gooding WE, Grandis JR,
2004 Sep
Cancer Res.
17
64
6166-73
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.
Cai W, Su L, Liao L, Liu ZZ, Langbein L, Dulaimi E, Testa JR, Uzzo RG, Zhong Z, Jiang W, Yan Q, Zhang Q, Yang H, 2019 Dec Nat Commun 1 10 5800Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection.
Rowe SE, Wagner NJ, Li L, Beam JE, Wilkinson AD, Radlinski LC, Zhang Q, Miao EA, Conlon BP, 2019 Dec Nat MicrobiolFoxO3 activation in hypoxic tubules prevents chronic kidney disease.
Li L, Kang H, Zhang Q, D'Agati VD, Al-Awqati Q, Lin F, 2019 03 J. Clin. Invest. 6 129 2374-2389Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer.
Kumar S, Srivastav RK, Wilkes DW, Ross T, Kim S, Kowalski J, Chatla S, Zhang Q, Nayak A, Guha M, Fuchs SY, Thomas C, Chakrabarti R, 2019 03 Oncogene 12 38 2092-2107
Wang L, Wrobel JA, Xie L, Li D, Zurlo G, Shen H, Yang P, Wang Z, Peng Y, Gunawardena HP, Zhang Q, Chen X
2018 Feb
Cell Chem Biol
Regulation of Hypoxia-Inducible Factor 1a during Hypoxia by DAP5-Induced Translation of PHD2.
Bryant JD, Brown MC, Dobrikov MI, Dobrikova EY, Gemberling SL, Zhang Q, Gromeier M, 2018 06 Mol. Cell. Biol. 11 38MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma.
Bailey ST, Smith AM, Kardos J, Wobker SE, Wilson HL, Krishnan B, Saito R, Lee HJ, Zhang J, Eaton SC, Williams LA, Manocha U, Peters DJ, Pan X, Carroll TJ, Felsher DW, Walter V, Zhang Q, Parker JS, Yeh JJ, Moffitt RA, Leung JY, Kim WY 2017 Jun Nat Commun 8 15770
Di Conza G, Trusso Cafarello S, Zheng X, Zhang Q, Mazzone M,
2017 03
Cell Rep
12
18
2836-2844
Exploring the role of CENP-A Ser18 phosphorylation in CIN and Tumorigenesis.
Zhang W, Karpen GH, Zhang Q, 2017 Cell Cycle 24 16 2323-2325EglN2 positively regulates mitochondrial function in breast cancer.
Zhang J, Zheng X, Zhang Q, 2016 Mar Mol Cell Oncol 2 3 e1120845Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.
Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG, 2016 Jun Cell 1 166 126-39
Takada M, Zhuang M, Inuzuka H, Zhang J, Zurlo G, Zhang J, Zhang Q
2016 Dec
Oncotarget
pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.
Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, Asara JM, Kaelin WG, Wei W 2016 Aug Science 6302 353 929-32New Insights into Protein Hydroxylation and Its Important Role in Human Diseases.
Zurlo G, Guo J, Takada M, Wei W, Zhang Q, 2016 12 Biochim. Biophys. Acta 2 1866 208-220Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.
Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, Lim E, Liu W, Bronson RT, Bowden M, Brock J, Krop IE, Dillon DA, Gygi SP, Mills GB, Richardson AL, Signoretti S, Yaffe MB, Kaelin WG 2014 Aug Cancer Cell 2 26 222-34XBP1 promotes triple-negative breast cancer by controlling the HIF1a pathway.
Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH 2014 Apr Nature 7494 508 103-7The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer.
Zhang Q, Yang H, 2012 Front Oncol 2 35
Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG, Yan Q
2011 Jul
13379-86
Li Y, Zhang Q, Tian R, Wang Q, Zhao JJ, Iglehart JD, Wang ZC, Richardson AL,
2011 Dec
Cancer Res.
24
71
7481-9
Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG, Harper JW, Wei W
2010 Aug
Cancer Cell
2
18
147-59
Seethala RR, Gooding WE, Handler PN, Collins B, Zhang Q, Siegfried JM, Grandis JR,
2008 Mar
Clin. Cancer Res.
5
14
1303-9
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.
Young AP, Schlisio S, Minamishima YA, Zhang Q, Li L, Grisanzio C, Signoretti S, Kaelin WG, 2008 Mar Nat. Cell Biol. 3 10 361-9
Nozawa H, Howell G, Suzuki S, Zhang Q, Qi Y, Klein-Seetharaman J, Wells A, Grandis JR, Thomas SM,
2008 Jul
Clin. Cancer Res.
13
14
4336-44
Wang J, Seethala RR, Zhang Q, Gooding W, van Waes C, Hasegawa H, Ferris RL,
2008 Apr
J. Natl. Cancer Inst.
7
100
502-12
Zhang Q, Bhola NE, Lui VW, Siwak DR, Thomas SM, Gubish CT, Siegfried JM, Mills GB, Shin D, Grandis JR,
2007 Apr
Mol. Cancer Ther.
4
6
1414-24
Decreased STAT1 expression by promoter methylation in squamous cell carcinogenesis.
Xi S, Dyer KF, Kimak M, Zhang Q, Gooding WE, Chaillet JR, Chai RL, Ferrell RE, Zamboni B, Hunt J, Grandis JR, 2006 Feb J. Natl. Cancer Inst. 3 98 181-9
Thomas SM, Bhola NE, Zhang Q, Contrucci SC, Wentzel AL, Freilino ML, Gooding WE, Siegfried JM, Chan DC, Grandis JR,
2006 Dec
Cancer Res.
24
66
11831-9
Lui VW, Thomas SM, Zhang Q, Wentzel AL, Siegfried JM, Li JY, Grandis JR,
2003 Sep
Oncogene
40
22
6183-93
Constitutive activation of Stat5b contributes to carcinogenesis in vivo.
Xi S, Zhang Q, Gooding WE, Smithgall TE, Grandis JR, 2003 Oct Cancer Res. 20 63 6763-71Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck.
Xi S, Zhang Q, Dyer KF, Lerner EC, Smithgall TE, Gooding WE, Kamens J, Grandis JR, 2003 Aug J. Biol. Chem. 34 278 31574-83