Publications

Featured Publications

Demonstrating Tumor Vascular Disrupting Activity of the Small-Molecule Dihydronaphthalene Tubulin-Binding Agent OXi6196 as a Potential Therapeutic for Cancer Treatment.

Liu L, Schuetze R, Gerberich JL, Lopez R, Odutola SO, Tanpure RP, Charlton-Sevcik AK, Tidmore JK, Taylor EA, Kapur P, Hammers H, Trawick ML, Pinney KG, Mason RP, 2022 Aug Cancers (Basel) 17 14

Imaging-Guided Evaluation of the Novel Small-Molecule Benzosuberene Tubulin-Binding Agent KGP265 as a Potential Therapeutic Agent for Cancer Treatment.

Guo Y, Wang H, Gerberich JL, Odutola SO, Charlton-Sevcik AK, Li M, Tanpure RP, Tidmore JK, Trawick ML, Pinney KG, Mason RP, Liu L, 2021 Sep Cancers (Basel) 19 13

Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors.

Liu L, O'Kelly D, Schuetze R, Carlson G, Zhou H, Trawick ML, Pinney KG, Mason RP, 2021 Apr Molecules 9 26

Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.

Zhang L, Zhang K, Zhang J, Zhu J, Xi Q, Wang H, Zhang Z, Cheng Y, Yang G, Liu H, Guo X, Zhou D, Xue Z, Li Y, Zhang Q, Da Y, Liu L, Yin Z, Yao Z, Zhang R, 2021 07 Nat Commun 1 12 4300

Oxygen-enhanced optoacoustic tomography reveals the effectiveness of targeting heme and oxidative phosphorylation at normalizing tumor vascular oxygenation.

Ghosh P, Guo Y, Ashrafi A, Chen J, Dey S, Zhong S, Liu J, Campbell J, Konduri PC, Gerberich J, Garrosian M, Mason RP, Zhang L, Liu L, 2020 Jun Cancer Res.

Restoration of miR-340 controls pancreatic cancer cell CD47 expression to promote macrophage phagocytosis and enhance antitumor immunity.

Xi Q, Zhang J, Yang G, Zhang L, Chen Y, Wang C, Zhang Z, Guo X, Zhao J, Xue Z, Li Y, Zhang Q, Da Y, Liu L, Yao Z, Zhang R, 2020 Jun J Immunother Cancer 1 8

Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression.

Kalainayakan SP, Ghosh P, Dey S, Fitzgerald KE, Sohoni S, Konduri PC, Garrossian M, Liu L, Zhang L 2019 Feb Sci Rep 1 9 1405

The vascular disrupting agent combretastatin A-4 phosphate causes prolonged elevation of proteins involved in heme flux and function in resistant tumor cells.

Dey S, Kumari S, Kalainayakan SP, Campbell J, Ghosh P, Zhou H, FitzGerald KE, Li M, Mason RP, Zhang L, Liu L 2018 Jan Oncotarget 3 9 4090-4101

Interactions of Renal-Clearable Gold Nanoparticles with Tumor Microenvironments: Vasculature and Acidity Effects.

Yu M, Zhou C, Liu L, Zhang S, Sun S, Hankins JD, Sun X, Zheng J 2017 Mar Angew. Chem. Int. Ed. Engl.

Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors.

Yan Y, Zhou K, Xiong H, Miller JB, Motea EA, Boothman DA, Liu L, Siegwart DJ 2017 Feb Biomaterials 118 84-93

Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells.

Yan Y, Liu L, Xiong H, Miller JB, Zhou K, Kos P, Huffman KE, Elkassih S, Norman JW, Carstens R, Kim J, Minna JD, Siegwart DJ 2016 Sep Proc. Natl. Acad. Sci. U.S.A. 39 113 E5702-10

In Vivo Chemiluminescent Imaging Agents for Nitroreductase and Tissue Oxygenation.

Cao J, Campbell J, Liu L, Mason RP, Lippert AR 2016 Apr Anal. Chem.

Imaging beta-galactosidase activity in human tumor xenografts and transgenic mice using a chemiluminescent substrate.

Liu L, Mason RP 2010 PLoS ONE 8 5 e12024

Development of aliphatic biodegradable photoluminescent polymers.

Yang J, Zhang Y, Gautam S, Liu L, Dey J, Chen W, Mason RP, Serrano CA, Schug KA, Tang L 2009 Jun Proc. Natl. Acad. Sci. U.S.A. 25 106 10086-91

Anti-GRP-R monoclonal antibody antitumor therapy against neuroblastoma

Qiao J, Liu J, Jacobson JC, Clark RA, Lee S, Liu L 2022 17 12 e0277956

The developments of metal-based agents against lung cancer

Gou Y, Liu L and Liang H 2022 Front. Pharmacol

Modulation of heme and tumor vascular oxygenation- a novel strategy for lung cancer therapy.

Ghosh P, Mason RP, Liu L, Zhang L, 2022 Oncoscience 9 66-69

In Situ Generated Novel 1H MRI Reporter for β-Galactosidase Activity Detection and Visualization in Living Tumor Cells

Shuo Gao, Lei Zhao, Zhiqiang Fan, Vikram D. Kodibagkar, Li Liu, Hanqin Wang, Hong Xu, Mingli Tu 2021 Front Chem

Use of copper-cysteamine nanoparticles to simultaneously enable radiotherapy, oxidative therapy and immunotherapy for melanoma treatment.

Zhang Q, Guo X, Cheng Y, Chudal L, Pandey NK, Zhang J, Ma L, Xi Q, Yang G, Chen Y, Ran X, Wang C, Zhao J, Li Y, Liu L, Yao Z, Chen W, Ran Y, Zhang R, 2020 May Signal Transduct Target Ther 1 5 58

F]Fluoroethyl-Tryptophan for PET Imaging of Cancer.

Xin Y, Gao X, Liu L, Ge WP, Jain MK, Cai H 2019 Feb Mol Imaging Biol

tRF/miR-1280 suppresses stem cell-like cells and metastasis in colorectal cancer.

Huang B, Yang H, Cheng X, Wang D, Fu S, Shen W, Zhang Q, Zhang L, Xue Z, Li Y, Da Y, Yang Q, Li Z, Liu L, Qiao L, Kong Y, Yao Z, Zhao P, Li M, Zhang R 2017 Apr Cancer Res.

Synthesis of a cell penetrating peptide modified superparamagnetic iron oxide and MRI detection of bladder cancer.

Ding C, Wu K, Wang W, Guan Z, Wang L, Wang X, Wang R, Liu L, Fan J 2016 Nov Oncotarget

Latex Carrier for Improving Protoporphyrin IX for Photodynamic Therapy.

Bui B, Liu L, Chen W 2016 Mar Photodiagnosis Photodyn Ther

Inorganic phosphate-triggered release of anti-cancer arsenic trioxide from a self-delivery system: an in vitro and in vivo study.

Chen FY, Yi JW, Gu ZJ, Tang BB, Li JQ, Li L, Kulkarni P, Liu L, Mason RP, Tang Q 2016 Mar Nanoscale 11 8 6094-100

Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization.

Herdman CA, Strecker TE, Tanpure RP, Chen Z, Winters A, Gerberich J, Liu L, Hamel E, Mason RP, Chaplin DJ, Trawick ML, Pinney KG 2016 Dec Medchemcomm 12 7 2418-2427

The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts.

Strecker TE, Odutola SO, Lopez R, Cooper MS, Tidmore JK, Charlton-Sevcik AK, Li L, MacDonough MT, Hadimani MB, Ghatak A, Liu L, Chaplin DJ, Mason RP, Pinney KG, Trawick ML 2015 Sep Cancer Lett.

Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization.

Herdman CA, Devkota L, Lin CM, Niu H, Strecker TE, Lopez R, Liu L, George CS, Tanpure RP, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG 2015 Oct Bioorg. Med. Chem.

Click-Chemistry Strategy for Labeling Antibodies with Copper-64 via a Cross-Bridged Tetraazamacrocyclic Chelator Scaffold.

Kumar A, Hao G, Liu L, Ramezani S, Hsieh JT, Öz OK, Sun X 2015 Mar Bioconjug. Chem.

Investigation of the Strategies for Targeting of the Afterglow Nanoparticles to Tumor Cells.

Rashidi LH, Homayoni H, Zou X, Liu L, Chen W 2015 Aug Photodiagnosis Photodyn Ther

One-pot Synthesis of Functional Poly(amino ester sulfide)s and Utility in Delivering pDNA and siRNA.

Yan Y, Xue L, Miller JB, Zhou K, Kos P, Elkassih S, Liu L, Nagai A, Xiong H, Siegwart DJ 2015 Aug Polymer (Guildf) 72 271-280

Dynamic bioluminescence and fluorescence imaging of the effects of the antivascular agent Combretastatin-A4P (CA4P) on brain tumor xenografts.

Liu L, Mason RP, Gimi B 2014 Oct Cancer Lett.

Development of Intrinsically Photoluminescent and Photostable Polylactones.

Xie Z, Zhang Y, Liu L, Weng H, Mason RP, Tang L, Nguyen KT, Hsieh JT, Yang J 2014 Mar Adv. Mater. Weinheim

Dynamic contrast enhanced fluorescent molecular imaging of vascular disruption induced by combretastatin-A4P in tumor xenografts.

Liu L, Su X, Mason RP 2014 Aug J Biomed Nanotechnol 8 10 1545-51

Red-shifted emission from 1,2-dioxetane-based chemiluminescent reactions.

Park JY, Gunpat J, Liu L, Edwards B, Christie A, Xie XJ, Kricka LJ, Mason RP 2014 Apr Luminescence

Novel Fe(3+)-Based (1)H MRI ?-Galactosidase Reporter Molecules**

Yu JX, Gulaka PK, Liu L, Kodibagkar VD, Mason RP 2012 May Chempluschem 5 77 370-378

Serial non-invasive monitoring of renal disease following immune-mediated injury using near-infrared optical imaging

Du Y., An S., Liu L, Mason RP, Li L., Zhou X., Mohan C. 2012 7 9 e43941

Tubulin-Destabilizing Agent BPR0L075 Induces Vascular-Disruption in Human Breast Cancer Mammary Fat Pad Xenografts.

Liu L, Beck H, Wang X, Hsieh HP, Mason RP, Liu X 2012 PLoS ONE 8 7 e43314

Comparison of optical and power Doppler ultrasound imaging for non-invasive evaluation of arsenic trioxide as a vascular disrupting agent in tumors.

Alhasan MK, Liu L, Lewis MA, Magnusson J, Mason RP 2012 PLoS ONE 9 7 e46106

A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment.

Mason RP, Zhao D, Liu L, Trawick ML, Pinney KG 2011 Apr Integr Biol (Camb) 4 3 375-87

S-Gal, a novel 1H MRI reporter for beta-galactosidase.

Cui W, Liu L, Kodibagkar VD, Mason RP 2010 Jul Magn Reson Med 1 64 65-71

Cell encapsulation and oxygenation in nanoporous microcontainers.

Gimi B, Kwon J, Liu L, Su Y, Nemani K, Trivedi K, Cui Y, Vachha B, Mason R, Hu W, Lee JB 2009 Dec Biomed Microdevices 6 11 1205-12

Evaluation of red CdTe and near infrared CdHgTe quantum dots by fluorescent imaging.

Zhang J, Su J, Liu L, Huang Y, Mason RP 2008 Mar J Nanosci Nanotechnol 3 8 1155-9

In vitro and In vivo Assessment of CdTe and CdHgTe Toxicity and Clearance.

Liu L, Zhang J, Su X, Mason RP 2008 Dec J Biomed Nanotechnol 4 4 524-528

A 19F-NMR approach using reporter molecule pairs to assess beta-galactosidase in human xenograft tumors in vivo.

Yu JX, Kodibagkar VD, Liu L, Mason RP 2008 Aug NMR Biomed 7 21 704-12

19F-NMR detection of lacZ gene expression via the enzymic hydrolysis of 2-fluoro-4-nitrophenyl beta-D-galactopyranoside in vivo in PC3 prostate tumor xenografts in the mouse.

Liu L, Kodibagkar VD, Yu JX, Mason RP 2007 Jul FASEB J. 9 21 2014-9

Imaging beta-galactosidase activity using 19F chemical shift imaging of LacZ gene-reporter molecule 2-fluoro-4-nitrophenol-beta-D-galactopyranoside.

Kodibagkar VD, Yu J, Liu L, Hetherington HP, Mason RP 2006 Sep Magn Reson Imaging 7 24 959-62

Synthesis and evaluation of novel enhanced gene reporter molecules: detection of beta-galactosidase activity using 19F NMR of trifluoromethylated aryl beta-D-galactopyranosides.

Yu J, Liu L, Kodibagkar VD, Cui W, Mason RP 2006 Jan Bioorg. Med. Chem. 2 14 326-33

Synthesis and evaluation of a novel gene reporter molecule: detection of beta-galactosidase activity using 19F NMR of a fluorinated vitamin B6 conjugate+.

Yu J, Ma Z, Li Y, Koeneman KS, Liu L, Mason RP 2005 May Med Chem 3 1 255-62

Novel NMR platform for detecting gene transfection: synthesis and evaluation of fluorinated phenyl beta-D-galactosides with potential application for assessing LacZ gene expression.

Yu J, Otten P, Ma Z, Cui W, Liu L, Mason RP 2004 Nov-Dec Bioconjug. Chem. 6 15 1334-41

Hereditary error in epidermal growth factor prohormone metabolism in a rat model of autosomal dominant polycystic kidney disease.

Lakshmanan J, Eysselein V, 1993 Dec Biochem Biophys Res Commun 3 197 1083-93

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