PGLYRP1-mediated intracellular peptidoglycan detection promotes intestinal mucosal protection
Chen S, Putnik R, Li X, Diwaker A, Vasconcelos M, Liu S, Gondi S, Zhou J, Guo L, Xu L, Temme S, Bersch K, Hyland S, Yin J, Burstein E, Bahnson BJ, Gildersleeve JC, Grimes CL, Reinecker HC 2025 Dec Nature communications 16Structural basis for Retriever-SNX17 assembly and endosomal sorting
Singla A, Boesch DJ, Fung HY, Ngoka C, Enriquez AS, Song R, Kramer DA, Han Y, Banarer E, Lemoff A, Juneja P, Billadeau DD, Bai X, Chen Z, Turer EE, Burstein E, Chen B 2024 Dec Nature communications 15Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism
Tan S, Santolaya JL, Wright TF, Liu Q, Fujikawa T, Chi S, Bergstrom CP, Lopez A, Chen Q, Vale G, McDonald JG, Schmidt A, Vo N, Kim J, Baniasadi H, Li L, Zhu G, He TC, Zhan X, Obata Y, Jin A, Jia D, Elmquist JK, Sifuentes-Dominguez L, Burstein E 2024 Jun Nature Metabolism 6 1076-1091Structural organization of the retriever–CCC endosomal recycling complex
Boesch DJ, Singla A, Han Y, Kramer DA, Liu Q, Suzuki K, Juneja P, Zhao X, Long X, Medlyn MJ, Billadeau DD, Chen Z, Chen B, Burstein E 2024 Jun Nature Structural and Molecular Biology 31 910-924Human peri-gastruloids: a significant advancement in embryology research
Yang Q, Burstein E, Jia D 2024 Jan MedComm 5SCGN deficiency is a risk factor for autism spectrum disorder
Liu Z, Tan S, Zhou L, Chen L, Liu M, Wang W, Tang Y, Yang Q, Chi S, Jiang P, Zhang Y, Cui Y, Qin J, Hu X, Li S, Liu Q, Chen L, Li S, Burstein E, Li W, Zhang X, Mo X, Jia D 2023 Dec Signal Transduction and Targeted Therapy 8RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation
Singh AK, Kumar R, Yin J, Brooks JF, Kathania M, Mukherjee S, Kumar J, Conlon KP, Basrur V, Chen Z, Han X, Hooper LV, Burstein E, Venuprasad K 2023 Dec Nature communications 14Maternal obesity, pregnancy weight gain, and birth weight and risk of colorectal cancer
Murphy CC, Cirillo PM, Krigbaum NY, Singal AG, Lee MJ, Zaki T, Burstein E, Cohn BA 2022 Jul Gut 71 1332-1339GMPPB-congenital disorders of glycosylation associate with decreased enzymatic activity of GMPPB
Liu Z, Wang Y, Yang F, Yang Q, Mo X, Burstein E, Jia D, Cai Xt, Tu Y 2021 Dec Molecular Biomedicine 2Immune Dysfunction in Mendelian Disorders of POLA1 Deficiency
Starokadomskyy P, Escala Perez-Reyes A, Burstein E 2021 Feb Journal of Clinical Immunology 41 285-293Regulation of murine copper homeostasis by members of the COMMD protein family
Singla A, Chen Q, Suzuki K, Song J, Fedoseienko A, Wijers M, Lopez A, Billadeau DD, van de Sluis B, Burstein E 2021 Jan DMM Disease Models and Mechanisms 14JAK Inhibition in a Patient with X-Linked Reticulate Pigmentary Disorder
Légeret C, Meyer BJ, Rovina A, Deigendesch N, Berger CT, Daikeler T, Heijnen I, Burstein E, Köhler H, Recher M 2021 Jan Journal of Clinical Immunology 41 212-216Paneth cell-derived growth factors support tumorigenesis in the small intestine
Chen Q, Suzuki K, Sifuentes-Dominguez L, Miyata N, Song J, Lopez A, Starokadomskyy P, Gopal P, Dozmorov I, Tan S, Ge B, Burstein E 2020 Dec Life Science Alliance 4Colorectal neoplasia among patients with and without human immunodeficiency virus
Faqih A, Singal AG, Fullington HM, Hewitt B, Burstein E, Gopal P, Wylie A, Abrams J, Murphy CC 2020 Aug Cancer Epidemiology Biomarkers and Prevention 29 1689-1691Structural and mechanistic insights into secretagogin-mediated exocytosis
Qin J, Liu Q, Liu Z, Pan YZ, Sifuentes-Dominguez L, Stepien KP, Wang Y, Tu Y, Tan S, Wang Y, Sun Q, Mo X, Rizo J, Burstein E, Jia D 2020 Mar Proceedings of the National Academy of Sciences of the United States of America 117 6559-6570Mosaic tetrasomy 9p associated with inflammatory bowel disease
Sifuentes-Dominguez L, Starokadomskyy P, Welch J, Gurram B, Park JY, Koduru P, Burstein E 2019 Oct Journal of Crohn's and Colitis 13 1474-1478Natural compounds in the chemoprevention of alcoholic liver disease
Tu Y, Zhu S, Wang J, Burstein E, Jia D 2019 Sep Phytotherapy Research 33 2192-2212Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation
Miyata N, Morris LL, Chen Q, Thorne C, Singla A, Zhu W, Winter M, Melton SD, Li H, Sifuentes-Dominguez L, Llano E, Huff-Hardy K, Starokadomskyy P, Lopez A, Reese TA, Turer E, Billadeau DD, Winter SE, Burstein E 2018 Aug Cell Reports 24 2342-2355Epithelial Na+ Channel: Reciprocal control by COMMD10 and Nedd4-2
Ware AW, Cheung TT, Rasulov S, Burstein E, McDonald FJ 2018 Jun Frontiers in Physiology 9Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation
Burger E, Araujo A, López-Yglesias A, Rajala MW, Geng L, Levine B, Hooper LV, Burstein E, Yarovinsky F 2018 Feb Cell Host and Microbe 23 177-190.e4Evolution of the skin manifestations of X-linked pigmentary reticulate disorder
Starokadomskyy P, Sifuentes-Dominguez L, Gemelli T, Zinn AR, Dossi MT, Mellado C, Bertrand P, Borzutzky A, Burstein E 2017 Nov British Journal of Dermatology 177 e200-e201Efficacy of Combination Vedolizumab and Ustekinumab for Refractory Crohn's Disease
Huff-Hardy K, Bedair M, Vazquez R, Burstein E 2017 Oct Inflammatory bowel diseases 23 E49Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling
McNally KE, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, Langton P, Pearson N, Danson CM, Nägele H, Morris LL, Singla A, Overlee BL, Heesom KJ, Sessions R, Banks L, Collins BM, Berger I, Billadeau DD, Burstein E, Cullen PJ 2017 Sep Nature cell biology 19 1214-1225Structural and mechanistic insights into regulation of the retromer coat by TBC1d5
Jia D, Zhang JS, Li F, Wang J, Deng Z, White MA, Osborne DG, Phillips-Krawczak C, Gomez TS, Li H, Singla A, Burstein E, Billadeau DD, Rosen MK 2016 Nov Nature communications 7DNA polymerase-α regulates the activation of type i interferons through cytosolic RNA:DNA synthesis
Starokadomskyy P, Gemelli T, Rios JJ, Xing C, Wang RC, Li H, Pokatayev V, Dozmorov I, Khan S, Miyata N, Fraile G, Raj P, Xu Z, Xu Z, Ma L, Lin Z, Wang H, Yang Y, Ben-Amitai D, Orenstein N, Mussaffi H, Baselga E, Tadini G, Grunebaum E, Sarajlija A, Krzewski K, Wakeland EK, Yan N, De La Morena MT, Zinn AR, Burstein E 2016 May Nature immunology 17 495-504CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
Bartuzi P, Billadeau DD, Favier R, Rong S, Dekker D, Fedoseienko A, Fieten H, Wijers M, Levels JH, Huijkman N, Kloosterhuis N, Van Der Molen H, Brufau G, Groen AK, Elliott AM, Kuivenhoven JA, Plecko B, Grangl G, McGaughran J, Horton JD, Burstein E, Hofker MH, Van De Sluis B 2016 Mar Nature communications 7Inhibiting cancer cell hallmark features through nuclear export inhibition
Sun Q, Chen X, Zhou Q, Burstein E, Yang S, Jia D 2016 Signal Transduction and Targeted Therapy 1Endosomal sorting of notch receptors through COM MD9-dependent pathways modulates notch signaling
Li H, Koo Y, Mao X, Sifuentes-Dominguez L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen JM, Vooijs M, Billadeau DD, Van de Sluis B, Cleaver O, Burstein E 2015 Nov Journal of Cell Biology 211 605-617Obesity in Inflammatory Bowel Disease: A Marker of Less Severe Disease
Flores A, Burstein E, Cipher DJ, Feagins LA 2015 Aug Digestive Diseases and Sciences 60 2436-2445Detection of IκB degradation dynamics and IκB-α ubiquitination
Starokadomskyy P, Burstein E 2015 Methods in Molecular Biology 1280 15-24A cell-type-specific role for murine Commd1 in liver inflammation
Bartuzi P, Wijshake T, Dekker DC, Fedoseienko A, Kloosterhuis NJ, Youssef SA, Li H, Shiri-Sverdlov R, Kuivenhoven JA, de Bruin A, Burstein E, Hofker MH, van de Sluis B 2014 Nov Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 2257-2265Bimolecular affinity purification: A variation of TAP with multiple applications
Starokadomskyy P, Burstein E 2014 Methods in Molecular Biology 1177 193-209COMMD1 regulates inflammation and colitis-associated cancer progression
Li H, Burstein E 2014 OncoImmunology 3Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin
Raetz M, Kibardin A, Sturge CR, Pifer R, Li H, Burstein E, Ozato K, Larin S, Yarovinsky F 2013 Nov Journal of Immunology 191 4818-4827Paraneoplastic diarrhea in a patient with lung adenocarcinoma
Nguyen AD, Valasek MA, Burstein E 2013 Oct Clinical Journal of Gastroenterology 6 357-360CCDC22 deficiency in humans blunts activation of proinfammatory NF-κB signaling
Starokadomskyy P, Gluck N, Li H, Chen B, Wallis M, Maine GN, Mao X, Zaidi IW, Hein MY, McDonald FJ, Lenzner S, Zecha A, Ropers HH, Kuss AW, McGaughran J, Gecz J, Burstein E 2013 May Journal of Clinical Investigation 123 2244-2256Deubiquitination of NF-κB by ubiquitin-specific protease-7 promotes transcription
Colleran A, Collins PE, O'Carroll C, Ahmed A, Mao X, McManus B, Kiely PA, Burstein E, Carmody RJ 2013 Jan Proceedings of the National Academy of Sciences of the United States of America 110 618-623The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB
Ziesché E, Kettner-Buhrow D, Weber A, Wittwer T, Jurida L, Soelch J, Müller H, Newel D, Kronich P, Schneider H, Dittrich-Breiholz O, Bhaskara S, Hiebert SW, Hottiger MO, Li H, Burstein E, Schmitz ML, Kracht M 2013 Jan Nucleic acids research 41 90-109Regulation of NF-B activity by competition between RelA acetylation and ubiquitination
Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine GN, Kracht M, Schmitz ML, Burstein E 2012 Feb Oncogene 31 611-623COMMD1 disrupts HIF-1α/β dimerization and inhibits human tumor cell invasion
Van De Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, Van Der Wall E, Van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E 2010 Jun Journal of Clinical Investigation 120 2119-2130GCN5 is a required cofactor for a ubiquitin ligase that targets NF-κB/RelA
Mao X, Gluck N, Li D, Maine GN, Li H, Zaidi IW, Repaka A, Mayo MW, Burstein E 2009 Apr Genes and Development 23 849-861COMMD1 expression is controlled by critical residues that determine XIAP binding
Maine GN, Mao X, Muller PA, Komarck CM, Klomp LW, Burstein E 2009 Jan Biochemical Journal 417 601-609Nuclear-cytosolic transport of COMMD1 regulates NF-κB and HIF-1 activity
Muller PA, De Sluis BV, Groot AJ, Verbeek D, Vonk WI, Maine GN, Burstein E, Wijmenga C, Vooijs M, Reits E, Klomp LW 2009 Traffic 10 514-527Bimolecular affinity purification (BAP): Tandem affinity purification using two protein baits
Maine GN, Gluck N, Zaidi IW, Burstein E 2009 Cold Spring Harbor Protocols 4Colitis and cancer: A tale of inflammatory cells and their cytokines
Burstein E, Fearon ER 2008 Feb Journal of Clinical Investigation 118 464-467COMMD1 promotes the ubiquitination of NF-κB subunits through a cullin-containing ubiquitin ligase
Maine GN, Mao X, Komarck CM, Burstein E 2007 Jan EMBO Journal 26 436-447Characterization of COMMD protein-protein interactions in NF-κB signalling
De Bie P, Van De Sluis B, Burstein E, Duran KJ, Berger R, Duckett CS, Wijmenga C, Klomp LW 2006 Aug Biochemical Journal 398 63-71COMMD proteins, a novel family of structural and functional homologs of MURR1
Burstein E, Hoberg JE, Wilkinson AS, Rumble JM, Csomos RA, Komarck CM, Maine GN, Wilkinson JC, Mayo MW, Duckett CS 2005 Jun Journal of Biological Chemistry 280 22222-22232Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression
Rudd BD, Burstein E, Duckett CS, Li X, Lukacs NW 2005 Mar Journal of virology 79 3350-3357VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation
Wilkinson JC, Richter BW, Wilkinson AS, Burstein E, Rumble JM, Balliu B, Duckett CS 2004 Dec Journal of Biological Chemistry 279 51091-51099Uncoupling of the Signaling and Caspase-inhibitory Properties of X-linked Inhibitor of Apoptosis
Lewis J, Burstein E, Reffey SB, Bratton SB, Roberts AB, Duckett CS 2004 Mar Journal of Biological Chemistry 279 9023-9029An Alternative Splice Form of Mdm2 Induces p53-independent Cell Growth and Tumorigenesis
Steinman HA, Burstein E, Lengner C, Gosselin J, Pihan G, Duckett CS, Jones SN 2004 Feb Journal of Biological Chemistry 279 4877-4886A novel role for XIAP in copper homeostasis through regulation of MURR1
Burstein E, Ganesh L, Dick RD, Van De Sluis B, Wilkinson JC, Klomp LW, Wijmenga C, Brewer GJ, Nabel GJ, Duckett CS 2004 Jan EMBO Journal 23 244-254The gene product Murr1 restricts HIV-1 replication in resting CD4 + lymphocytes
Ganesh L, Burstein E, Guha-Niyogi A, Louder MK, Mascola JR, Klomp LW, Wijmenga C, Duckett CS, Nabel GJ 2003 Dec Nature 426 853-857Dying for NF-κB? Control of cell death by transcriptional regulation of the apoptotic machinery
Burstein E, Duckett CS 2003 Dec Current Opinion in Cell Biology 15 732-737Join Our Lab
There are frequent opportunities to join our lab. If you have an interest in the research that we are conducting and would like to be considered for a position in the lab, please send an email including your CV and a letter of interest to Ezra Burstein.