Issued Patents

Compositions and Methods for Preserving DNA Methylation. Markowitz, S.; Moinova, H.; Ready, J. (2025). U.S. Patent No. 12,404,538 B2.

Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity. Markowitz, S.; Ready, J.M.; Gwaltney, S.L.; Antczak, M. (2025). U.S. Patent No. 12,336,982 B2.

Inhibitors of Short-Chain Dehydrogenase Activity for Treating Coronary Disorders. Markowitz, S.; Ho, W. J.; Yuan, Y.; Jain, M.; Sabeh, M.; Ready, J.; Williams, N. (2022). U.S. Patent No. 11,426,420 B2.

Compositions and Methods for Modulating Cervical Ripening. Word, R. A.; Annavarapu, H. K.; Posner, B.; Ready, J.; Markowitz, S. (2019). WO 2019010482.

Preparation of Thienopyridines and Related Compounds, Their Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity. Markowitz, S.; Antczak, M.; Ready, J.; Zhang, Y. (2018). WO 2018218251.

Preparation of Pyrazolopyrimidine and Quinoxaline Derivatives for Modulating Short-Chain Dehydrogenase Activity. Markowitz, S. D.; Yuan, Y.; Zhang, Y.; Ready, J.; Hu, B. (2018). WO 2018145080.

Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity. Markowitz, S.; Willson, J.K.V.; Posner, B.; Ready, J.M.; Antczak, M.; Zhang, Y.; Desai, A.; Gerson, S.; Greenlee, W. (2017). U.S. Patent No. 9,789,116 B2.

Compositions and Methods of Modulating 15-PGDH Activity. Markowitz, S.; Willson, J.K.V.; Posner, B.; Ready, J.M.; Zhang, Y.; Hsin-Hsiung, T.; Antczak, M.; Gerson, S.; Bae, K.; Yang, S.Y.; Desai, A. (2017). U.S. Patent No. 9,790,233 B2.

Preparation of Benzothiophenes and Other Compounds and Methods and Compositions for Selective and Targeted Cancer Therapy. Ready, J.M.; Nijhawan, D.; Gonzales, S.S.; Theodoropoulos, P. (2015). WO 2015/035051 A1.

Methods for Treating Parkinson’s Disease Using Pro-Neurogenic Compounds. McKnight, S.L.; Pieper, A.A.; Ready, J.M.; De Brabander, J. (2014). U.S. Patent No. 8,877,797.

Methods of Treating Traumatic Brain Injury Using Pro-Neurogenic Compounds. McKnight, S.L.; Pieper, A.A.; Ready, J.M.; De Brabander, J. (2014). U.S. Patent No. 8,791,149 B2.

Methods of Treating Post-Traumatic Stress Disorder Using Pro-Neurogenic Compounds. McKnight, S.L.; Pieper, A.A.; Ready, J.M.; De Brabander, J. (2014). U.S. Patent No. 8,748,473 B2.

Chemical Inducers of Neurogenesis. Schneider, J.; Hsieh, J.; Frantz, D. E.; McKnight, S. L.; Ready, J. M. (2014). U.S. Patent No. 8,778,940 B2.

Methods for Treating Amyotrophic Lateral Sclerosis Using Pro-Neurogenic Compounds. McKnight, S.L.; Pieper, A.A.; Ready, J.M.; De Brabander, J. (2014). U.S. Patent No. 8,735,440 B2.

Proneurogenic Compounds. McKnight, S.L.; Pieper, A.A.; Ready, J.M.; De Brabander, J. (2013). U.S. Patent No. 8,604,074.

Proneurogenic Compounds. McKnight, S.L.; Pieper, A.A.; Ready, J.M.; De Brabander, J. (2013). U.S. Patent No. 8,362,277.

Isoxazole Amides, Derivatives and Methods of Chemical Induction of Neurogenesis. Schneider, J.; Hsieh, J.; Frantz, D. E.; McKnight, S. L.; Ready, J. M. (2012). U.S. Patent No. 8,193,225.