Development of Mucosal Immunity

We study human genetic diversity associated with inflammatory bowel diseases to understand the principal mechanisms of mucosal immunity that control the intestinal barrier function and the microbiome.

GEF-H1 Regulation of Anti-tumor Immunity

Dendritic cell targeting through the GEF-H1 immune pathway may be utilized to overcome the immune tolerant tumor environment and improve the utility of current immune checkpoint blockade and personalized cancer vaccinations.