GEF-H1-Dependent Regulation of Anti-Tumor Immunity

We discovered that intracellular activation of the GEF-H1 signaling pathway induces immune responses and dendritic cell maturation similar to microbial pattern recognition receptors. GEF-H1 directed immunity emerges as a critical mechanism that controls dendritic cell maturation upon disruption of microtubules.

This immune activation pathway is induced by microtubule destabilization and controls maturation of dendritic cells for anti-tumor immune responses. Dendritic cell targeting through the GEF-H1 immune pathway may be utilized to overcome the immune tolerant tumor environment and improve the utility of current immune checkpoint blockade and personalized cancer vaccinations.

Predicted partial structure of GEFH1

Ribbon diagram of protein