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Our goal is to employ cryo-EM to determine high resolution structures of important membrane protein complexes involved in cellular signaling, including cellular receptors and ion channels. We also combine structural approaches with functional studies to reveal the structure-function relationships of these membrane proteins.
We study the role of chromatin regulation in cell fate decisions.
We combine classical genetics with modern technology to understand human physiology and search for breakthrough treatments for diseases.
Dr. Mizuno's laboratory studies autonomic control of the cardiovascular system, particularly the underlying alterations in circulatory control in type 1 or type 2 diabetes and Alzheimer’s disease.
Dr. Bedimo studies strategies for optimally managing drug-resistant HIV patients, analyzing metabolic abnormalities in HIV patients, and studying the effects of HCV co-infection.
We strive to decipher mechanisms of structural, functional, and electrical remodeling in heart disease with an eye toward therapeutic intervention.
Our lab is creating better experimental models that reveal how cancer cells metastasize and evade our immune system. We use these models to develop new drugs that engage our immune system to kill cancer cells.
Welcome to the Reproductive Genomics Laboratory (RGL) at UT Southwestern Medical Center where we innovate at the intersection of genomics, bioengineering, and data science to answer fundamental questions in reproductive biology.
The Chook Lab studies physical and cellular mechanisms of Kaps. Our long-term goals are to understand how the macromolecular nuclear traffic patterns coordinated by the 20 human Kaps contribute to overall cellular organization.
The Dean Lab aims to develop and apply cutting-edge microscopy instrumentation and analyses to gain insight into otherwise intractable biological problems.
Proper control of metabolism is required for essentially every basic biological process. Altered metabolism at the cellular level contributes to several serious diseases including inborn errors of metabolism (the result of inherited genetic defects in metabolic enzymes that lead to chemical imbalances in children) and cancer. Our laboratory seeks to characterize these metabolic disorders, understand how they compromise tissue function, develop methods to monitor metabolism in vivo and design therapies to restore normal metabolism and improve health.
We study the physical mechanisms that underlie animal development.
The Elmquist laboratory uses mouse genetics to identify circuits in the nervous system that regulate energy balance and glucose homeostasis. We have developed unique mouse models allowing neuron-specific manipulation of genes regulating these processes.
Bacteria and phages are in everlasting conflict – constantly devising new genes, systems, and mechanisms to keep pace with their competitors. The Forsberg lab studies this “evolutionary arms race”, using high-powered selections to unearth new functions and careful experiments to reveal their mechanisms.
Obesity and metabolic diseases have been increasing at the alarming rate and threatening our health and economy over the world. However, we still don’t know much about how our metabolic homeostasis is regulated. Understanding the mechanism underlying the regulation of metabolism is a fundamental step towards designing new treatments for obesity and its associated diseases, and many other metabolic diseases
The autonomic nervous system comprises a network of sensory and motor neurons that connect the brainstem and spinal cord to thoracic and abdominal organs. A better understanding of the anatomical and functional plasticity of the autonomic nervous system will likely move forward our understanding of numerous chronic diseases including, but not limited to, obesity, diabetes, visceral pain, neuropathy, and eating disorders.
The Jain Lab is broadly interested in sex disparities in research on women's health, as well as the impact of sex hormones on airway diseases and immune response.
We use theoretical methods to study proteins, genomes and organisms.
The Grow lab takes genome-wide, single-cell, and computational approaches to deeply understand epigenome and transcriptome landscapes and how they are reprogrammed.
