Our lab studies the fundamental mechanisms of how commensal fungi survive and persist within a host niche filled with a multitude of innate and adaptive immune effectors, under both homeostatic and inflammatory conditions. We aim for our study to provide unique insights into human diseases, such as asthma, inflammatory bowel disease, and cancer, and provides the foundation for novel immunotherapeutic approaches.
In the Izumi Lab, with the ultimate goal of identifying druggable molecules/pathways in pediatric genetic disorders, we investigate the molecular mechanisms of pediatric genetic disorders due to chromosomal abnormalities and chromatin protein mutations. We employ novel genetic approaches by using patient-derived samples, induced pluripotent stem cell models and mutant mouse models.
The Greenberg Lab focuses on translational research relative to autoimmune disorders of the central nervous system.
Our lab is interested in understanding the relationship between injury, regeneration, and cancer. We are focused on identifying the genes and mechanisms that regulate regenerative capacity in the liver and understanding how these contribute to hepatocellular carcinoma development.
The lab focuses on developing bioinformatics algorithms and deep learning models to identify new disease genes and therapeutic targets for human diseases, as well as development and maintenance of data management system for genomic and clinical databases.
The long-term goal of our lab is to understand the functions of ecDNA and how ecDNA is maintained in cancer.
Our goal is to better understand the mechanisms that maintain adult tissues and how cancer cells hijack these mechanisms to enable the formation of tumors.
Our research focuses on how mitochondria are embedded in normal cellular function.
Our goal is to identify the metabolic mechanisms that push cells to become cancerous and find new ways to inhibit them.
The Parkland Outcomes after Prematurity Study research group focuses on the short- and long-term effects of preterm birth, to improve lifelong health outcomes for current and future patients.
