My lab has a long-time interest in understanding the mechanisms of transcription and gene regulation in mammalian cells using initially cell-free systems reconstituted with purified gene-specific transcription factors, general cofactors, and components of the general transcription machinery to recapitulate transcriptional events in vitro. 

The Zhang Lab studies intra- and inter-molecular interactions to understand how signaling proteins are regulated, using biochemistry, X-ray crystallography, cryo-EM and cell biology.

We are developing inhibitors of pyrimidine biosynthesis and polyamine biosynthesis to treat malaria and African sleeping sickness. We study polyamine and nucleotide metabolism in African trypanosomes to learn about novel metabolism and regulation.

Corey Lab is using nucleic acids or nucleic acid mimics to explore important cellular processes, develop novel therapeutic tools and strategies.