Huen Lab studies how metabolic adaption promotes survival during sepsis and how the kidneys contribute to systemic metabolism during inflammation.

The main focus of the Minna Lab is translational (“bench to bedside”) cancer research aimed at developing new ways to diagnose, prevent, and treat lung cancer based on a detailed understanding of the molecular pathogenesis of lung cancer.

The Mangelsdorf/Kliewer Lab studies two signal transduction pathways that offer new therapeutic potential for treating diseases such as diabetes, obesity, cancer, and parasitism.

The Burgess lab uses Nuclear Magnetic Resonance spectroscopy and Mass Spectrometry in conjunction with stable isotope (non-radioactive) tracers to study how metabolic flux is altered by disease, pharmacology, or targeted genetic interventions.

The Brekken laboratory, located in the Hamon Center for Therapeutic Oncology Research, studies tumor-host interactions with a particular emphasis on extracellular matrix (ECM) and angiogenesis.

We are interested in understanding the deregulation of epigenetic and transcriptional pathways in human disease and in finding small molecules with therapeutic potential to normalize these gene expression patterns. 

We are working at the interface of nanotechnology, drug delivery, and tumor immunology

My lab has a long-time interest in understanding the mechanisms of transcription and gene regulation in mammalian cells using initially cell-free systems reconstituted with purified gene-specific transcription factors, general cofactors, and components of the general transcription machinery to recapitulate transcriptional events in vitro. 

The Zhang Lab studies intra- and inter-molecular interactions to understand how signaling proteins are regulated, using biochemistry, X-ray crystallography, cryo-EM and cell biology.

We are developing inhibitors of pyrimidine biosynthesis and polyamine biosynthesis to treat malaria and African sleeping sickness. We study polyamine and nucleotide metabolism in African trypanosomes to learn about novel metabolism and regulation.