Jain (Raksha) Lab
Description
The Jain Lab is broadly interested in sex disparities in research on women's health, as well as the impact of sex hormones on airway diseases and immune response.
Skin Immunity & Microbiome Research Publications | Harris-Tryon Lab at UTSW
Featured Discoveries
Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing
John, M.S., Chinnappan, M., Sturges, C.I. et al. Nat Microbiol 11, 704–717 (2026)
Cutaneous Hormone Production Is Distinct between Anatomical Sites and between Males and Females
J. Pineider, K. M. Eckert, J. G. McDonald, T. A. Harris-Tryon, Journal of Investigative Dermatology, Volume 143, Issue 4, 2023,
Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis
C. Zhang, M. Chinnappan, C.A. Prestwood, M. Edwards, M. Artami, B.M. Thompson, K.M. Eckert, G. Vale, C.C. Zouboulis, J.G. McDonald, & T.A. Harris-Tryon, Proc. Natl. Acad. Sci. U.S.A. 118 (38)
Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption
C. Zhang, Z. Hu, A. G. Lone, M. Artami, M. Edwards, C. C. Zouboulis, M. Stein, T. A. Harris-Tryon, 2022, eLife
Saprophytic bacteria and fungi colonize stearoyl coenzyme-A desaturase-1 knockout skin
Pyle HJ, Artami M, Edwards M, et al. Exp Dermatol. 2023;32:78-84
Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin
Harris T, Gattu S, Propheter D, Hooper L et. al, Cell Host & Microbe, 2019; 25, 777-788.e8
Assessment of the Cutaneous Hormone Landscapes and Microbiomes in Vulvar Lichen Sclerosus
H. J. Pyle, J. C. Evans, M. Artami, P. Raj, S. Sridharan, C. Arana, K. M. Eckert, J. G. McDonald, T. A. Harris-Tryon, M. M. Mauskar, Journal of Investigative Dermatology, Volume 144, Issue 8, 2024,Featured Reviews
Microbiota and maintenance of skin barrier function
Tamia A. Harris-Tryon, Elizabeth A. Grice , Science376,940-945(2022)
Skin immunity: dissecting the complex biology of our body's outer barrier
C. Zhang, G. R. Merana, T. A. Harris-Tryon, T. C. Scharschmidt, Mucosal Immunology, Volume 15, Issue 4, 2022
Cutaneous Hormone Sampling and Analysis for Dermatologic Research
C. I. Sturges, S.Jain, M. Velasquez, H. Gedamu, J. Komarovsky, J. G. McDonald, T. A. Harris-Tryon, Journal of Investigative Dermatology, Volume 145, Issue 8, 2025
Novel mechanisms of microbial crosstalk with skin innate immunity
Fritzlaine C. Roche and Tamia A. Harris-Tryon
Illuminating the Role of Vitamin A in Skin Innate Immunity and the Skin Microbiome: A Narrative Review
Fritzlaine C. Roche and Tamia A. Harris-Tryon, Nutrients 2021, 13(2), 302
A Staphylococcus Path to Improved Therapeutics in Atopic Dermatitis
Tamia A. Harris-Tryon, Shai Bel, JAMA Dermatol, 2021
Further Publications
For a comprehensive list of Dr. Harris Tryon's publications, click here.Explore peer-reviewed publications from the Harris-Tryon Lab at UT Southwestern, covering skin immunity, the cutaneous microbiome, antimicrobial proteins, and dermatology research.