The Tong lab studies the cellular and molecular mechanisms of cardiovascular diseases associated with systemic metabolic disorders, particularly heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF), with an eye toward translating these findings into innovative solutions to clinical problems.
Dr. Prinz's research is focused on the tiny organelles within cells that do the cell’s work, much like the organs in a human body. He is best known for studies into the exchange of fats (also called lipids) between organelles at so-called membrane contact sites where organelles come in close contact within a cell.
We believe that understanding the basic biology of the schistosomes is key to developing the next generation of anti-schistosome drugs and vaccines. We also contend that by studying the basic biology of these fascinating organisms, we can better understand important basic biological processes common to all animals, including humans. For that reason, we study schistosomes from multiple angles using a variety of modern molecular approaches.of the lab.
Our laboratory discovered a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control cholesterol and fatty acid synthesis.
The over-arching theme of the Weaver Lab is to deeply understand how proteolytic factors mediate diverse physiological functions.
We are interested in the molecular mechanisms by which nuclear hormone receptors regulate lipid and carbohydrate metabolism in the liver, intestine, pancreatic islet, and central nervous system.
The mission of the Najafov Lab is to understand the role of cell death in physiology and disease. Our research is focused on necroptosis and how it can be targeted to develop novel strategies for treating cancer.
The Munshi Lab is a dedicated group of scientists seeking to identify the molecular drivers of normal cardiac rhythm and disease-associated dysrhythmias.
Our research focuses on how mitochondria are embedded in normal cellular function.
We study the molecular events that drive this process in a term pregnancy and how perturbation of these processes contribute to premature birth.
