The Ye Lab is broadly interested in lipid-mediated signaling reactions.

A major focus of the Horton lab is to determine how these transcriptional regulators contribute to the development of steatosis in various disease processes such as diabetes, obesity, and beta-oxidation defects. A second area of investigation centers on determining the function of PCSK9, a protein that is involved in determining plasma LDL cholesterol levels through its ability to post-transcriptionally regulate the expression of the LDL receptor in liver.

The Robertson Lab studies mitochondrial and metabolic homeostasis in the corneal epithelium and the role of homeostatic dysfunction in the pathophysiology of corneal disease.

The HMG CoA reductase regulatory system researched by DeBose-Boyd Lab involves a complex, multivalent feedback mechanism that is mediated by sterol and nonsterol end-products of mevalonate metabolism.

How do cells sense metabolites to drive their growth and proliferation?  We seek to study metabolites not only as nutrients but as cellular instruction signals that dictate cell biology. 

The Tong lab studies the cellular and molecular mechanisms of cardiovascular diseases associated with systemic metabolic disorders, particularly heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF), with an eye toward translating these findings into innovative solutions to clinical problems.

Dr. Prinz's research is focused on the tiny organelles within cells that do the cell’s work, much like the organs in a human body. He is best known for studies into the exchange of fats (also called lipids) between organelles at so-called membrane contact sites where organelles come in close contact within a cell. 

Our laboratory discovered a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control cholesterol and fatty acid synthesis. 

The over-arching theme of the Weaver Lab is to deeply understand how proteolytic factors mediate diverse physiological functions.

We are interested in the molecular mechanisms by which nuclear hormone receptors regulate lipid and carbohydrate metabolism in the liver, intestine, pancreatic islet, and central nervous system.