research lab at UT Southwestern for Yun Wei, Ph.D.

Wang Lab focuses on how genetic factor and transcription regulation function in skeletal disease and bone cancer.

We unite researchers with diverse expertise in computational modeling, biochemical reconstitution, structural analysis of polymers, and cell biology to focus on three distinct condensates that are important for genome homeostasis.

Our laboratory is interested in understanding how the ubiquitin-mediated protein degradation regulates gene expression and how failure of these pathways contributes to developmental disorders and diseases, such as neurodegeneration and cancer.

The Nanes Lab investigates how the keratin intermediate filament cytoskeleton organizes cell regulatory circuits during skin development, wound healing, and cancer.

The Ye Lab is broadly interested in lipid-mediated signaling reactions.

A major focus of the Horton lab is to determine how these transcriptional regulators contribute to the development of steatosis in various disease processes such as diabetes, obesity, and beta-oxidation defects. A second area of investigation centers on determining the function of PCSK9, a protein that is involved in determining plasma LDL cholesterol levels through its ability to post-transcriptionally regulate the expression of the LDL receptor in liver.

The Robertson Lab studies mitochondrial and metabolic homeostasis in the corneal epithelium and the role of homeostatic dysfunction in the pathophysiology of corneal disease.

The HMG CoA reductase regulatory system researched by DeBose-Boyd Lab involves a complex, multivalent feedback mechanism that is mediated by sterol and nonsterol end-products of mevalonate metabolism.

How do cells sense metabolites to drive their growth and proliferation?  We seek to study metabolites not only as nutrients but as cellular instruction signals that dictate cell biology.