Our goal is to employ cryo-EM to determine high resolution structures of important membrane protein complexes involved in cellular signaling, including cellular receptors and ion channels. We also combine structural approaches with functional studies to reveal the structure-function relationships of these membrane proteins.
The Marciano laboratory investigates fundamental aspects of kidney development and regeneration, in both health and disease.
Michaely Lab focuses on the function of the proteins that control plasma membrane function. We have on-going projects investigating ARH/LDLR endocytosis and caveolae signal transduction.
Working at the boundary between science and philosophy with the goal to inform public policy and advance science education and public understanding of science.
Shay Lab is interested in the relationships between aging and cancer and have focused on the role of the telomeres and telomerase in these processes.
The overarching goal of Wen-hong Li Lab is to investigate mechanisms responsible for maintaining islet cell function and to devise new strategies for enhancing beta cell fitness and robustness to prevent or treat diabetes.
The Sorrell Laboratory utilizes integrative approaches that include metabolomics, transcriptomics, organoid cultures, live microcopy, and animal models, to investigate fundamental pathways that control the uptake of nutrients and the biosynthesis of macromolecules in proliferative cells.
The Seemann Lab studies the molecular mechanisms governing the function and inheritance of the mammalian Golgi apparatus.
Mukhopadhyay Lab research aims to understand how the primary cilium regulates downstream pathways to ultimately drive morphogenesis in different tissues. We undertake a multi-pronged approach including proteomics, cell biology, biochemistry, reverse genetics, and generation of innovative mouse models to study regulation of signaling pathways by cilia in in cellular and organismal contexts.
Our laboratory actively studies disease processes that disrupt normal metabolism.
