The Sankary Neuroethics Lab at UT Southwestern explores the ethical dimensions of neuroscience and neurosurgical innovation.

Understanding brain circuits in disease and cognition to develop restorative neuromodulation. 

We leverage our knowledge of fundamental neuroscience to create wearable bidirectional brain-machine interfaces for the restoration and assistance of upper limb sensation and movement in people with paralysis.

The Cullum Lab, led by Dr. Munro Cullum, has three lines of research in the areas of concussion, aging and dementia, and neuropsychological assessment. The lab aims to capture comprehensive longitudinal data on sports-related concussions and other mTBI across the lifespan, with an emphasis on adolescent sport-related injuries. The lab also collaborates with research groups investigating early detection of cognitive impairment later in life as well as sport and military-related traumatic brain injury. 

Our research focuses on developing and testing novel immunotherapies for meningiomas (the most common brain tumors in adults) as well as on understanding the tumor immune microenvironment of meningiomas and other skull base tumors.

The Noch Lab is a basic and translational research laboratory focused on identifying novel strategies to target metabolic vulnerabilities in glioma.

At the Fu Lab of human neuroscience we investigate the neural bases of cognitive control.

We aim to elucidate the role of the innate immune system in damage and repair following ischemic and hemorrhagic insults to the brain. We are specifically focused on innate immune drivers of secondary injury following aneurysmal subarachnoid hemorrhage and the immune response triggered by acute intracranial pressure spikes during aneurysm rupture. We also look into promoting recovery after ischemic stroke by reprogramming microglia and peripheral myeloid cells to drive repair. In addition, we are pursuing the development of therapeutics for intraarterial immunomodulation for chronic subdural hemorrhage.

Dr. LoBue's BRAIN lab, short for Brain Aging, Injury, and Modulation Lab, has two lines of research in the area of aging and neurodegenerative diseases. The lab investigates the later-in-life effects of traumatic brain injury, which involves understanding the potential risk associated with developing dementia and the underlying biological pathways. The lab also studies the effects of noninvasive brain stimulation in Alzheimer’s disease and related disorders with the goal of informing the development of new treatments.

Our lab focuses on investigating the brain circuits implicated in treatment resistant depression with the ultimate goal of developing novel therapies for this devastating disease.