The Wang lab applies single-molecule fluorescence biophysical, quantitative biochemical, structural, and genetics approaches to unravel the intricate relationships between structure, dynamics and function in complex dynamic biological systems. Our primary goal is to understand the dynamic mechanisms of cytosolic and mitochondrial protein synthesis and how they are dysregulated in human diseases.

The over-arching theme of the Weaver Lab is to deeply understand how proteolytic factors mediate diverse physiological functions.

The Kraus Lab is interested in the basic mechanisms of nuclear signaling and gene regulation by small molecules and how these signaling pathways relate to human physiology and disease states.

My lab has a long-time interest in understanding the mechanisms of transcription and gene regulation in mammalian cells using initially cell-free systems reconstituted with purified gene-specific transcription factors, general cofactors, and components of the general transcription machinery to recapitulate transcriptional events in vitro. 

D'Orso Lab studies gene regulatory networks in normal and disease states as well as in the context of host-pathogen interactions.