Publications

Featured Publications

AIF3 splicing variant elicits mitochondrial malfunction via the concurrent dysregulation of electron transport chain and glutathione-redox homeostasis.

Zhou M, Liu S, Wang Y, Zhang B, Zhu M, Wang JE, Rajaram V, Fang Y, Luo W, Wang Y, 2025 Feb Nat Commun 1 16 1804

KDM6B promotes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response.

Yang M, Wang C, Zhou M, Bao L, Wang Y, Kumar A, Xing C, Luo W, Wang Y, 2022 Jun Nucleic Acids Res

Emerging role of PARP-1 and PARthanatos in ischemic stroke.

Liu S, Luo W, Wang Y, 2022 Jan J Neurochem 1 160 74-87

KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2.

Wang Y, Khandelwal N, Liu S, Zhou M, Bao L, Wang JE, Kumar A, Xing C, Gibson JR, Wang Y, 2022 Aug Mol Psychiatry

MIF promotes neurodegeneration and cell death via its nuclease activity following traumatic brain injury.

Ruan Z, Lu Q, Wang JE, Zhou M, Liu S, Zhang H, Durvasula A, Wang Y, Wang Y, Luo W, Wang Y, 2021 Dec Cell Mol Life Sci

AIF3 splicing switch triggers neurodegeneration.

Liu S, Zhou M, Ruan Z, Wang Y, Chang C, Sasaki M, Rajaram V, Lemoff A, Nambiar K, Wang JE, Hatanpaa KJ, Luo W, Dawson TM, Dawson VL, Wang Y, 2021 Apr Mol Neurodegener 1 16 25

MIF is a 3' flap nuclease that facilitates DNA replication and promotes tumor growth.

Wang Y, Chen Y, Wang C, Yang M, Wang Y, Bao L, Wang JE, Kim B, Chan KY, Xu W, Capota E, Ortega J, Nijhawan D, Li GM, Luo W, Wang Y, 2021 05 Nat Commun 1 12 2954

ZMYND8 expression in breast cancer cells blocks T-lymphocyte surveillance to promote tumor growth.

Wang Y, Luo M, Chen Y, Wang Y, Zhang B, Ren Z, Bao L, Wang Y, Wang JE, Fu YX, Luo W, Wang Y, 2020 Nov Cancer Res

PARP-1 and its associated nucleases in DNA damage response.

Wang Y, Luo W, Wang Y, 2019 Jul DNA Repair (Amst.) 102651

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim BW, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam T, Jeong JS, Xie Z, Neifert S, Qian J, Andrabi SA, Blackshaw S, Zhu H, Song H, Ming GL, Dawson VL, Dawson TM 2016 Science PMID: 27846469 (* Corresponding authors)

ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2.

Luo M, Bao L, Xue Y, Zhu M, Kumar A, Xing C, Wang JE, Wang Y, Luo W, 2024 Jan J Clin Invest 6 134

SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1.

Bao L, Kumar A, Zhu M, Peng Y, Xing C, Wang JE, Wang Y, Luo W, 2023 Sep J Clin Invest 17 133

Targeting BCAT1 combined with a-ketoglutarate triggers metabolic synthetic lethality in glioblastoma.

Zhang B, Peng H, Zhou M, Bao L, Wang C, Cai F, Zhang H, Wang JE, Niu Y, Chen Y, Wang Y, Hatanpaa K, Copland JA, DeBerardinis RJ, Wang Y, Luo W, 2022 May Cancer Res

ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells.

Luo M, Bao L, Chen Y, Xue Y, Wang Y, Zhang B, Wang C, Corley CD, McDonald JG, Kumar A, Xing C, Fang Y, Nelson ER, Wang JE, Wang Y, Luo W, 2022 07 Sci Adv 28 8 eabn5295

Multifaceted role of branched-chain amino acid metabolism in cancer.

Peng H, Wang Y, Luo W, 2020 Oct Oncogene 44 39 6747-6756

Isolated Erythrocytosis Associated With 3 Novel Missense Mutations in the EGLN1 Gene.

Moore JA, Hubbi ME, Wang C, Wang Y, Luo W, Hofmann S, Rambally S, 2020 Jan-Dec J Investig Med High Impact Case Rep 8 2324709620947256

HIF-2-induced long non-coding RNA RAB11B-AS1 promotes hypoxia-mediated angiogenesis and breast cancer metastasis.

Niu Y, Bao L, Chen Y, Wang C, Luo M, Zhang B, Zhou M, Wang JE, Fang YV, Kumar A, Xing C, Wang Y, Luo W, 2020 Jan Cancer Res.

Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma.

Zhang B, Chen Y, Shi X, Zhou M, Bao L, Hatanpaa KJ, Patel T, DeBerardinis RJ, Wang Y, Luo W, 2020 Feb Cell. Mol. Life Sci.

LncIHAT Is Induced by Hypoxia-Inducible Factor 1 and Promotes Breast Cancer Progression.

Chen L, Bao L, Niu Y, Wang JE, Kumar A, Xing C, Wang Y, Luo W, 2020 Dec Mol Cancer Res

CHD4 promotes breast cancer progression as a coactivator of hypoxia-inducible factors.

Wang Y, Chen Y, Zhang B, Bao L, Wang JE, Kumar A, Xing C, Wang Y*, Luo W*. 2020 Cancer Res. 80 3880-3891. (*corresponding author).

Hypoxia Mediates Tumor Malignancy and Therapy Resistance.

Luo W, Wang Y, 2019 Adv. Exp. Med. Biol. 1136 1-18

ZMYND8 is a primary HIF coactivator that mediates breast cancer progression.

Chen Y, Wang Y, Luo W 2018 Mol Cell Oncol 4 5 e1479619

ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis

Chen Y, Zhang B, Bao L, Jin L, Yang M, Peng Y, Kumar A, Wang JE, Wang C, Zou X, Xing C, Wang Y, Luo W 2018 J Clin Invest. PMID: 29629903 (* Corresponding authors)

Methylation of hypoxia-inducible factor (HIF)-1a by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration

Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y*, Luo W*. 2018 Nucleic Acids Res. PMID: 29860315 (*Corresponding authors)

Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-a protein stability and activity

Luo W, Wang Y 2017 Cell. Mol. Life Sci.

HIF repressors under chronic hypoxia.

Luo W, Wang Y 2016 Mar Aging (Albany NY)

PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia.

Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza GL 2016 Feb Oncotarget

PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility.

Luo W, Lin B, Wang Y, Zhong J, O'Meally R, Cole RN, Pandey A, Levchenko A, Semenza GL 2014 Sep Mol. Biol. Cell 18 25 2788-96

New synaptic and molecular targets for neuroprotection in Parkinson's disease.

Calabresi P, Di Filippo M, Gallina A, Wang Y, Stankowski JN, Picconi B, Dawson VL, Dawson TM 2013 Jan Mov. Disord. 1 28 51-60

Proteinase-activated receptors, nucleotide P2Y receptors, and µ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.

Luo W, Wang Y, Reiser G 2011 Apr J. Neurochem. 1 117 71-81

Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos).

Wang Y, Kim NS, Haince JF, Kang HC, David KK, Andrabi SA, Poirier GG, Dawson VL, Dawson TM 2011 Sci Signal 167 4 ra20

Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos).

Wang Y, Kim NS, Li X, Greer PA, Koehler RC, Dawson VL, Dawson TM 2009 Jul J. Neurochem. 2 110 687-96

Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos.

Wang Y, Dawson VL, Dawson TM 2009 Aug Exp. Neurol. 2 218 193-202

Outer mitochondrial membrane localization of apoptosis-inducing factor: mechanistic implications for release.

Yu SW, Wang Y, Frydenlund DS, Ottersen OP, Dawson VL, Dawson TM 2009 ASN Neuro 5 1

Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions.

Wang Y, Luo W, Reiser G 2008 Jan Cell. Mol. Life Sci. 2 65 237-52

p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking.

Luo W, Wang Y, Reiser G 2007 Oct J. Biol. Chem. 41 282 30246-55

The role of calcium in protease-activated receptor-induced secretion of chemokine GRO/CINC-1 in rat brain astrocytes.

Wang Y, Luo W, Reiser G 2007 Oct J. Neurochem. 2 103 814-9

Proteinase-activated receptor-1 and -2 induce the release of chemokine GRO/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain.

Wang Y, Luo W, Reiser G 2007 Jan Biochem. J. 1 401 65-78

Activation of protease-activated receptors in astrocytes evokes a novel neuroprotective pathway through release of chemokines of the growth-regulated oncogene/cytokine-induced neutrophil chemoattractant family.

Wang Y, Luo W, Reiser G 2007 Dec Eur. J. Neurosci. 11 26 3159-68

Protease-activated receptors in the brain: receptor expression, activation, and functions in neurodegeneration and neuroprotection.

Luo W, Wang Y, Reiser G 2007 Dec Brain Res Rev 2 56 331-45

Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes.

Wang Y, Luo W, Wartmann T, Halangk W, Sahin-Tóth M, Reiser G 2006 Nov J. Neurochem. 3 99 759-69

Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1.

Luo W, Wang Y, Hanck T, Stricker R, Reiser G 2006 Mar J. Biol. Chem. 12 281 7927-36

Protease-activated receptor-1 protects rat astrocytes from apoptotic cell death via JNK-mediated release of the chemokine GRO/CINC-1.

Wang Y, Luo W, Stricker R, Reiser G 2006 Aug J. Neurochem. 4 98 1046-60

Two types of protease-activated receptors (PAR-1 and PAR-2) mediate calcium signaling in rat retinal ganglion cells RGC-5.

Luo W, Wang Y, Reiser G 2005 Jun Brain Res. 2 1047 159-67

Molecular recognition in purinergic receptors. 2. Diastereoselectivity of the h-P2Y1-receptor.

Major DT, Nahum V, Wang Y, Reiser G, Fischer B 2004 Aug J. Med. Chem. 18 47 4405-16

Expression of protease-activated receptors (PARs) in OLN-93 oligodendroglial cells and mechanism of PAR-1-induced calcium signaling.

Wang Y, Richter-Landsberg C, Reiser G 2004 Neuroscience 1 126 69-82

Books

Thrombin: Physiology and Disease

Thrombin: Physiology and Disease

Luo W, Wang Y, Reiser G.

The role of thrombin and thrombin receptors in the brain. 

Editors: N. Tsopanoglou, M. Maragoudakis, Springer Verlag (2008).