Publications

Bi, P. and Geisbrecht, E. (2024)
Cell fusion: Inter-organ tissue communication promotes a union between myoblasts.
Current Biology 34: 343-345.

Ruan, Z-R., Yu, Z., Xing, C., and Chen, E.H. (2024)
Inter-organ steroid hormone signaling promotes myoblast fusion via direct transcriptional regulation of a single key effector gene.
Current Biology 34: 1438-1452.

Lu, Y., Walji, T., Ravaux, B., Pandey, P., Li, B., Lam, K. H., Zhang, R., Goldhamer, D., Li, R., Schmidtke, D., Pan, D., and Chen, E. H. (2023)  
Molecular Regulation of Invasive Protrusion Formation at the Mammalian Fusogenic Synapse 
bioRxiv, Preprint. DOI: 10.1101/2023.11.27.568897

Cornelius, S., Colonetta, M., Lake, K., Smith, C., Zhang, Y.A., Roussos-Torres, E., Reddy, S., Chen, E.H., and Chan, I. (2022) 
Generating and Imaging Mouse and Human Epithelial Organoids from Normal and Tumor Mammary Tissue Without Passaging 
J Vis Exp. DOI: 10.3791/64626

Wang, L., Choi, K., Su, T., Li, B., Wu, X., Zhang, R., Driskill, J., Li, H., Lei, H., Guo, P., Chen, E.H., Zheng, Y., and Pan, D. (2022)
Multiphase coalescence mediates Hippo pathway activation
Cell 185: 4376-4393.

Wu, P., Yong, P., Zhang, Z., Xu, R., Shang, R., Shi, J., Zhang, J., Bi, P., Chen, E.H., and Du, S. (2022)
Loss of Myomixer results in defective myoblast fusion, impaired muscle growth, and severe myopathy in zebrafish
Marine Biotechnology 24: 1023-1038.

Chen, E.H. (2022)
To fuse or to divide, that was the question
Nat Rev Mol Cell Biol 24. DOI: 10.1038/s41580-022-00533-3

Wu, B-K., Mei, S-C., Chen, E.H., Zheng, Y., and Pan, D. (2022)
Yap induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis
Nat Genet 54: 1202-1213.

*Luo, Z., Shi, J., Pandey, P., Ruan, Z-R., Sevdali, M., Bu, Y., Lu, Y., Du, S., and Chen E.H. (2022) 
The cellular architecture and molecular determinants of the zebrafish fusogenic synapse
Dev Cell 57: 1582-197.

Zheng, C., Hu, Y., Sakurai, M., Pinzon-Arteaga, C.A., Li, J., Wie, Y., Okamura, D,. Ravaux, B., Barlow, H.R., Yu, L., Sun, H-X., Chen, E.H., Gu, Y., and Wu, J. (2021)
Cell competition constitutes a barrier for interspecies chimerism
Nature 592: 272-276.

*Zhang, R., Lee, D.M., Jimah, J.R., Gerassimov, N., Yang, C., Kim, S., Luvsanjav, D., Winkelman, J., Metteln, M., Abrams, M.E., Kalia, R., Keene, P., Pandey, P., Ravaux, B., Kim, J.H., Ditlev, J.A., Zhang, G., Rosen, M.K., Frost, A., Alto, N.M., Gardel, M., Schmid, S.L., Svitkina, T.M., Hinshaw, J.E., and Chen, E.H. (2020)
Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-binding protein
Nat Cell Biol 22: 674-688. (cover article).
Faculty Opinions
UT Southwestern Medical Center news release

Kim, J.H. and Chen, E.H. (2019)
The fusogenic synapse at a glance 
J Cell Sci 132. DOI: 10.1242/jcs.213124

Lee, D.M. and Chen, E.H. (2019)
Drosophila Myoblast Fusion: Invasion and Resistance for the Ultimate Union
Annu Rev Genet 53: 67-91.

Andrew, D.J., Chen, E.H., Manoli, D.S., Ryner, L.C., and Arbeitman, M.N. (2019)
Sex and the single fly: A perspective on the career of Bruce S. Baker 
Genetics 212: 365-376.

*Duan, R., Kim, J.H., Shilagardi, K., Schiffhauer, E.S., Lee, D.M., Son, S., Li, S., Thomas, C., Luo, T., Fletcher, D.A., Robinson, D.N., and Chen, E.H. (2018)
Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion
Nat Cell Biol 20: 688-698.

Shi, J., Bi, P., Pei, J., Li, H., Grishin, N.V., Bassel-Duby, R., Chen, E.H., and Olson, E.N. (2017)
Requirement of the fusogenic micropeptide myomixer for muscle formation in zebrafish
Proc Natl Acad Sci USA 114: 11950-11955.

Antonny, B., Burd, C., De Camilli, P., Chen, E.H., Daumke, O., Faelber, K. Ford, M., Frolov, V.A., Frost, A., Hinshaw, J.E., Kirchhausen, T., Kozlov, M.M., Lenz, M., Low, H.H., McMahon, H., Merrifield, C., Pollard, T.D., Robinson, P.J., Roux, A., and Schmid, S.
Membrane fission by dynamin: what we know and what we need to know 
EMBO J 35: 2270-2284.

*Kim, J.H., Jin, P., Duan, R., and Chen, E.H. (2015)
Mechanisms of myoblast fusion during muscle development
Curr Opin Genet Dev 32: 162-70.

*Kim, J.H., Ren, Y, Ng, W.P., Li, S., Son, S., Kee, Y-S., Zhang, S., Zhang, G., Fletcher, D.A., Robinson, D.N., and Chen, E.H. (2015)
Mechanical tension drives cell membrane fusion
Dev Cell 32: 561-573.
NIH Biomedical Beat
Developmental Cell Preview

Chen, E. and Sedwick, C. (2014)
Elizabeth Chen: Fusing cells press closer
J Cell Biol 206: 576-577.

*Shilagardi, K., Li, S., Luo, F., Marikar, F., Duan, R., Jin, P., Kim, J.H., Murnen, K., and Chen, E.H. (2013)
Actin-propelled invasive membrane protrusions promote fusogenic protein engagement during cell-cell fusion 
Science 340: 359-363.
Nature Research Highlight
Johns Hopkins University news release

Duan, R., Jin, P., Luo, F., Zhang, G., Anderson, N., and Chen, E.H. (2012)
Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo 
J Cell Biol 199: 169-185.

Chen, E.H. (2011)
Invasive podosomes and myoblast fusion
Curr Top Membr 68: 235-258. 

*Jin, P., Duan, R., Luo, F., Zhang, G., Hong, S.N., and Chen, E.H. (2011)
Competition between Blown fuse and WASP for WIP binding regulates the dynamics of WASP-dependent actin polymerization in vivo
Dev Cell 20: 623-638.

*Sens, K.L., Zhang, S., Jin, P., Duan, R., Zhang, G., Luo, F., Parachini, L., and Chen, E.H. (2010)
An invasive podosome-like structure promotes fusion pore formation during myoblast fusion 
J Cell Biol 191: 1013-1027.
Nature Reviews Molecular Cell Biology Research Highlight
Journal of Cell Biology news release
Current Biology Dispatch
Johns Hopkins University news release

Zhang, S. and Chen, E.H. (2008)
Ultrastructural analysis of myoblast fusion in Drosophila
Methods Mol Biol 475: 275-297.

Kim, S., Shilagardi, K., Zhang, S., Hong, S.N., Sens, K.L., Bo, J., Gonzalez, G.A., and Chen, E.H. (2007)
A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusion 
Dev Cell 12: 571-586.
Developmental Cell Preview

Chen, E.H., Grote, E., Mohler, W.A., and Vignery, A. (2007)
Cell-cell fusion 
FEBS Letters 581: 2181-2193.

Chen, E.H. and Olson, E.N. (2005)
Unveiling the mechanisms of cell-cell fusion 
Science 308: 369-373. 

Chen, E.H. and Olson, E.N. (2004)
Towards a molecular pathway of myoblast fusion in Drosophila 
Trends Cell Biol 14: 452-460.

Chen, E.H., Pryce, B.A., Tzeng J.A., Gonzalez, G.A., and Olson, E.N. (2003)
Control of myoblast fusion by a guanine nucleotide exchange factor, Loner, and its effector ARF6 
Cell 114: 751-762.
Developmental Cell Preview

Chen, E.H. and Olson, E.N. (2001)
Antisocial, an intracellular adaptor protein, is required for myoblast fusion in Drosophila
Dev Cell 1: 705-715.

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