Publications

BRD4 isoforms have distinct roles in tumour progression and metastasis in rhabdomyosarcoma.

Das D, Leung JY, Balamurugan S, Tergaonkar V, Loh AHP, Chiang CM, Taneja R, 2024 Jan EMBO Rep

Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function.

Prabhakar AT, James CD, Fontan CT, Otoa R, Wang X, Bristol ML, Yeager C, Hill RD, Dubey A, Wu SY, Chiang CM, Morgan IM, 2023 Sep J Virol e0078223

IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors.

Wu SY, Lai HT, Sanjib Banerjee N, Ma Z, Santana JF, Wei S, Liu X, Zhang M, Zhan J, Chen H, Posner B, Chen Y, Price DH, Chow LT, Zhou J, Chiang CM, 2023 Dec Mol Cell

Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping.

Yang H, Sui P, Guo Y, Chen S, Maloof ME, Ge G, Nihozeko F, Delma CR, Zhu G, Zhang P, Ye Z, Medina EA, Ayad NG, Mesa R, Nimer SD, Chiang CM, Xu M, Chen Y, Yang FC, 2023 Aug EMBO Rep e57032

Targeting ESR1 mutation-Induced transcriptional addiction in breast cancer with BET inhibition.

Udden SN, Wang Q, Kumar S, Malladi VS, Wu SY, Wei S, Posner BA, Geboers S, Williams NS, Liu YL, Sharma JK, Mani RS, Malladi S, Parra K, Hofstad M, Raj GV, Larios JM, Jagsi R, Wicha MS, Park BH, Gupta GP, Chinnaiyan AM, Chiang CM, Alluri PG, 2022 Jul JCI Insight

Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site.

Liu Z, Li Y, Chen H, Lai HT, Wang P, Wu SY, Wold EA, Leonard PG, Joseph S, Hu H, Chiang CM, Brasier AR, Tian B, Zhou J, 2022 Jan J Med Chem

Conditional Human BRD4 Knock-In Transgenic Mouse Genotyping and Protein Isoform Detection.

Lewis MP, Wu SY, Chiang CM, 2022 Apr Bio Protoc 7 12

Functional coordination of BET family proteins underlies altered transcription associated with memory impairment in fragile X syndrome.

Kim SK, Liu X, Park J, Um D, Kilaru G, Chiang CM, Kang M, Huber KM, Kang K, Kim TK, 2021 May Sci Adv 21 7

KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs.

Bacon CW, Challa A, Hyder U, Shukla A, Borkar AN, Bayo J, Liu J, Wu SY, Chiang CM, Kutateladze TG, D'Orso I, 2020 May Mol. Cell

Opposing Functions of BRD4 Isoforms in Breast Cancer.

Wu SY, Lee CF, Lai HT, Yu CT, Lee JE, Zuo H, Tsai SY, Tsai MJ, Ge K, Wan Y, Chiang CM, 2020 May Mol. Cell

Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein.

Li J, Chen Z, Chen F, Xie G, Ling Y, Peng Y, Lin Y, Luo N, Chiang CM, Wang H, 2020 Jun Nucleic Acids Res. 10 48 5684-5694

PCAF-mediated acetylation of ISX recruits BRD4 to promote epithelial-mesenchymal transition.

Wang LT, Liu KY, Jeng WY, Chiang CM, Chai CY, Chiou SS, Huang MS, Yokoyama KK, Wang SN, Huang SK, Hsu SH, 2020 Jan EMBO Rep. e48795

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

Kim JJ, Lee SY, Gong F, Battenhouse AM, Boutz DR, Bashyal A, Refvik ST, Chiang CM, Xhemalce B, Paull TT, Brodbelt JS, Marcotte EM, Miller KM, 2019 Nov Genes Dev.

Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail.

Lu L, Chen Z, Lin X, Tian L, Su Q, An P, Li W, Wu Y, Du J, Shan H, Chiang CM, Wang H, 2019 May Cell Death Differ.

Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis.

Penas C, Maloof ME, Stathias V, Long J, Tan SK, Mier J, Fang Y, Valdes C, Rodriguez-Blanco J, Chiang CM, Robbins DJ, Liebl DJ, Lee JK, Hatten ME, Clarke J, Ayad NG, 2019 Jul Nat Commun 1 10 3028

Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.

Zhao J, Lee EE, Kim J, Yang R, Chamseddin B, Ni C, Gusho E, Xie Y, Chiang CM, Buszczak M, Zhan X, Laimins L, Wang RC, 2019 05 Nat Commun 1 10 2300

SUMO suppresses and MYC amplifies transcription globally by regulating CDK9 sumoylation.

Yu F, Shi G, Cheng S, Chen J, Wu SY, Wang Z, Xia N, Zhai Y, Wang Z, Peng Y, Wang D, Du JX, Liao L, Duan SZ, Shi T, Cheng J, Chiang CM, Li J, Wong J 2018 Mar Cell Res.

BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer.

Li X, Baek G, Ramanand SG, Sharp A, Gao Y, Yuan W, Welti J, Rodrigues DN, Dolling D, Figueiredo I, Sumanasuriya S, Crespo M, Aslam A, Li R, Yin Y, Mukherjee B, Kanchwala M, Hughes AM, Halsey WS, Chiang CM, Xing C, Raj GV, Burma S, de Bono J, Mani RS 2018 Jan Cell Rep 3 22 796-808

Uncovering BRD4 hyperphosphorylation associated with cellular transformation in NUT midline carcinoma.

Wang R, Cao XJ, Kulej K, Liu W, Ma T, MacDonald M, Chiang CM, Garcia BA, You J 2017 Jun Proc. Natl. Acad. Sci. U.S.A.

Phospho-BRD4: transcription plasticity and drug targeting.

Chiang CM 2016 Mar Drug Discov Today Technol 19 17-22

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.

Shu S, Lin CY, He HH, Witwicki RM, Tabassum DP, Roberts JM, Janiszewska M, Huh SJ, Liang Y, Ryan J, Doherty E, Mohammed H, Guo H, Stover DG, Ekram MB, Peluffo G, Brown J, D'Santos C, Krop IE, Dillon D, McKeown M, Ott C, Qi J, Ni M, Rao PK, Duarte M, Wu SY, Chiang CM, Anders L, Young RA, Winer EP, Letai A, Barry WT, Carroll JS, Long HW, Brown M, Liu XS, Meyer CA, Bradner JE, Polyak K 2016 Jan Nature 7586 529 413-7

Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4.

Delcuratolo M, Fertey J, Schneider M, Schuetz J, Leiprecht N, Hudjetz B, Brodbeck S, Corall S, Dreer M, Schwab RM, Grimm M, Wu SY, Stubenrauch F, Chiang CM, Iftner T 2016 Jan PLoS Pathog. 1 12 e1005366

Involvement of Brd4 in different steps of the papillomavirus life cycle.

Iftner T, Haedicke-Jarboui J, Wu SY, Chiang CM 2016 Dec Virus Res.

BRD4 Phosphorylation Regulates HPV E2-Mediated Viral Transcription, Origin Replication, and Cellular MMP-9 Expression.

Wu SY, Nin DS, Lee AY, Simanski S, Kodadek T, Chiang CM 2016 Aug Cell Rep 6 16 1733-48

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

Kim DH, Kwon S, Byun S, Xiao Z, Park S, Wu SY, Chiang CM, Kemper B, Kemper JK 2016 Nat Commun 7 12179

Regulation of mammalian transcription and splicing by Nuclear RNAi.

Kalantari R, Chiang CM, Corey DR 2015 Nov Nucleic Acids Res.

Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription.

Nagarajan S, Hossan T, Alawi M, Najafova Z, Indenbirken D, Bedi U, Taipaleenmäki H, Ben-Batalla I, Scheller M, Loges S, Knapp S, Hesse E, Chiang CM, Grundhoff A, Johnsen SA 2014 Jul Cell Rep 2 8 460-9

Nonequivalent Response to Bromodomain-Targeting BET Inhibitors in Oligodendrocyte Cell Fate Decision.

Chiang CM 2014 Jul Chem. Biol. 7 21 804-6

Brd4 is displaced from HPV replication factories as they expand and amplify viral DNA.

Sakakibara N, Chen D, Jang MK, Kang DW, Luecke HF, Wu SY, Chiang CM, McBride AA 2013 Nov PLoS Pathog. 11 9 e1003777

Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting.

Wu SY, Lee AY, Lai HT, Zhang H, Chiang CM 2013 Jan Mol. Cell

Sumoylation in gene regulation, human disease, and therapeutic action.

Yang XJ, Chiang CM 2013 F1000Prime Rep 5 45

p53-Aurora A mitotic feedback loop regulates cell cycle progression and genomic stability.

Chiang CM 2012 Oct Cell Cycle 20 11 3719-20

Binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription.

Wang WM, Wu SY, Lee AY, Chiang CM 2011 Nov J. Biol. Chem. 47 286 40974-86