The application of Focused Ultrasound (FUS) coupled with IV administration of microbubbles is a unique method whereby localized opening of the BBB can be achieved in a non-invasive manner. Low-intensity pulsed FUS exposures delivered to brain regions with circulating intravascular microbubbles cause the microbubbles within the path of the acoustic beam to interact with the endothelial lining, leading to the reversible and nondestructive opening of the BBB. Under MRI guidance LDL based nanomedicine can successfully be delivered to the brain for the treatment of tumors or other disease processes.
