Redox Biology

For more than eight decades, it has been known that cancer cells exhibit altered metabolism when compared to their normal counterparts. Increased rates of glycolysis are commonly recognized as a metabolic hallmark of cancer, but in more recent years there is increasing evidence that perturbations in cancer cell oxidative metabolism results in increased steady-state levels of reactive oxygen species (ROS), including superoxide (O2.-) and H202. Here in the Corbin Lab, we employ various methods (chemical, fluorescent and spectroscopic) to detect, characterize and investigate the implications of deviant redox homeostasis on cancer’s biology.

ROS signal from rat liver chart