The long-term goal of our lab's research is to develop and implement imaging technologies that provide unprecedented insight into cancer biology.
To increase the realism of cell culture and cancer drug screens, we have abandoned traditional cell cultures on hard glass surfaces and moved towards 3D environments, both ex-vivo and in-vivo. This requires continuous development of dedicated 3D microscope technologies that minimize specimen photodamage and maximize optical penetration depth, image acquisition speed, sensitivity, and spatial resolution.
3D Cancer Morphodynamics
Welf, Erik S., etal. Developmental cell 36.4 (2016): 462-475.
Imaging in 3D Microenvironments
Shedding new light on cancer metastasis with innovative microscopes.
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