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The Busch Lab develops optical technologies for minimally and non-invasive bedside assessment of microvascular blood flow and oxygen saturation, allowing continuous assessment of aerobic metabolism. 

The primary research focus of the Karner lab is to create and utilize novel mouse genetic models to study the role of cellular metabolism during skeletal development and disease. 

Zeng Lab is interested in understanding at the molecular level key questions lying at the interface between biochemistry, cell biology, metabolic and neural physiology, including the bidirectional communication between autonomic neurons and adipocytes, the molecular basis of the phenotypic plasticity, or the lack of, in brown, beige and white adipocytes, and roles of uncharacterized enzymatic pathways in adipose thermogenesis.

This facility is the home to five high field solution NMR spectrometers ranging from 500 MHz to 800 MHz and a Solid State 600 MHz DNP system, primarily in support of studies of macromolecular structure, function and dynamics.

The Rosen Lab seeks to understand the formation, regulation, functions and internal structures of membraneless cellular compartments termed biomolecular condensates.

Saelices Lab employs crystallography and cryo-EM to study amyloid deposition and design anti-amyloid tools.

The Bailey lab focuses on developing gene therapies for neurological disorders. We work on monogenetic pediatric disorders, including SLC13A5 epileptic encephalopathy, multiple sulfatase deficiency, Charcot Marie Tooth disease type 4J, giant axonal neuropathy and ECHS1 deficiency.

Henne lab is interested in how cells spatially organize their metabolism to adapt to a constantly changing environment.

The Chong Research group has been conducting clinical and translational research on cutaneous lupus including outcome measure development for clinical trials, biomarkers for diagnosis and prognosis, and disease outcomes.

Buszczak laboratory seeks to gain new insights into mRNA translation, ribosome biogenesis and germ cell biology 

The Dellinger Laboratory studies the development of the lymphatic vasculature and diseases caused by errors in the development of lymphatic vessels.

The Glass lab focuses on how genes regulate skin development and function by studying how gene mutations or abnormal gene expression lead to skin disease.

The long-term goal of Fiolka Lab's research is to develop and implement imaging technologies that provide unprecedented insight into cancer biology. 

The Bowen Lab focuses on the development of hybrid positron emission tomography (PET) (e.g. PET-CT and PET-MR) tools to enable precision imaging for the care and study of oncology, neurology, and cardiology patients.

The Burgess lab uses Nuclear Magnetic Resonance spectroscopy and Mass Spectrometry in conjunction with stable isotope (non-radioactive) tracers to study how metabolic flux is altered by disease, pharmacology, or targeted genetic interventions.

Dr. Maldjian's ANSIR Lab is devoted to the application of novel image analysis methods (e.g. diffeomorphic registration, machine learning, graph theory, ASL) to research studies, as well as to robust clinical translation of these techniques.

The lab's long-term goal is to illuminate the function of immune surface molecules and to open up a new research field at the interface of cancer, immunology, and stem cell research. Zhang Lab also actively develops novel therapies for cancer treatment.

The Mangelsdorf/Kliewer Lab studies two signal transduction pathways that offer new therapeutic potential for treating diseases such as diabetes, obesity, cancer, and parasitism.

The ultimate aim of the Shiloh Lab is to contribute to the development of vaccines and treatments for Mycobacterium tuberculosis (Mtb).

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