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We focus on neurodegenerative diseases linked to amyloid protein accumulation with the goal of developing mechanism-based diagnosis and therapy.

The Mendell laboratory investigates fundamental aspects of post-transcriptional gene regulation, noncoding RNA regulation and function, and the roles of these pathways in normal physiology, cancer, and other diseases.

Texas Computational Memory Lab research focuses on analyzing the neural activity that gives rise to successful memories and facilitates memory retrieval. 

The goal of the Krämer laboratory is to understand the molecular mechanisms that regulate responses to diverse cellular stresses.

Our laboratory studies the cell biology of viral-host interactions. 

The mission in the Meng Lab is to develop a better understanding of how fundamental alterations to cell polarity contribute towards development of invasive disease in kidney cancer.

The Sandstrom Lab works to identify the fundamental molecular mechanisms through which the immune system can recognize pathogens and stress. 

The Jiang lab studies fundamental mechanisms governing how diverse cell types are generated from naive progenitor cells and how cells of different types are put together to form appropriate body structures such as limbs during embryonic development. The lab also studies how damaged cells are replenished by stem cells during tissue repair and organ regeneration in adult life. We are particularly interested in understanding how cells communicate with one another to influence their growth and fate determination and how miscommunication among different cells leads to developmental abnormality and cancer progression.

The Nicastro Lab studies 3D ultra-structures and cell biological functions of macro-molecular complexes inside cells.

The main focus of the Minna Lab is translational (“bench to bedside”) cancer research aimed at developing new ways to diagnose, prevent, and treat lung cancer based on a detailed understanding of the molecular pathogenesis of lung cancer.

Mirpuri Lab is focused on neonatal innate immunity and the role of maternal diet (mHFD), dietary metabolites and innate lymphoid cells in offspring outcomes.

Zhan Lab's mission is to advance medical genetics research through cutting-edge statistic models and computationally efficient software tools

The main goals of the Strand Lab are to create accurate cellular atlases of the human and mouse lower urinary tract, characterize the molecular and cellular alterations in human lower urinary tract disease, and design new mouse models.

Our research is driven by a desire to understand how these microscopic machines both replicate themselves and, at the same time, manage to evade, manipulate, and counter a myriad of host defenses. 

The Tagliabracci Lab studies the phosphorylation of extracellular proteins by a novel family of secreted kinases. This kinase family is so different from canonical kinases that it was not included as a branch on the human kinome tree.

Huen Lab studies how metabolic adaption promotes survival during sepsis and how the kidneys contribute to systemic metabolism during inflammation.

O'Donnell Lab investigates mechanisms of tumor initiation, progression, and metastasis using molecular and biochemical studies and animal models.

Pouratian Lab's primary mission is to explore basic human neuroscientific principles as well as identify brain mapping biomarkers of disease that can drive innovative approaches to restore function to patients with neurological and psychiatric diseases.

Goldsmith Lab combines drug discovery and mechanistic analysis to understanding protein kinases. 

Orchard Lab at UT Southwestern Medical Center