Leveraging powerful new cell-based and cell-free systems, high-speed fluorescence imaging, and in vitro reconstitution using purified components to understand how cellular organelles such as peroxisomes are formed, how they acquire their unique identities and functions, and how defects in these processes cause human disease.

Deja Lab is dedicated to advancing the field of metabolomics and fluxomics in metabolic disease research.

The Wang lab applies single-molecule fluorescence biophysical, quantitative biochemical, structural, and genetics approaches to unravel the intricate relationships between structure, dynamics and function in complex dynamic biological systems. Our primary goal is to understand the dynamic mechanisms of cytosolic and mitochondrial protein synthesis and how they are dysregulated in human diseases.

We are investigating how protein homeostasis (the maturation and turnover of enzymes) interacts with lipid homeostasis.

The Tu Lab is investigating how a variety of cellular processes and decisions are coordinated with metabolic state, and how the dysregulation of these mechanisms might be linked to disease and aging.

We aim to globally understand how the physical and chemical properties of materials affect interactions with biological systems in the context of improving therapies.

The Nam lab asks how the shape of an RNA regulates its function. We study the biochemical and structural mechanisms in RNA-mediated gene regulation pathways important for normal and disease states.

 In diseases like cancer, signaling pathways can be corrupted by mutations that cause the cells to grow and spread uncontrollably. Our lab is interested in understanding how these defective pathways reprogram cellular metabolism to drive cancer growth.

We use theoretical methods to study proteins, genomes and organisms.

The Wetzel Lab targets critical steps in the parasite’s life cycle in order to develop therapeutics for Leishmaniasis.