The Lin Lab studies the transformation of brief experiences into enduring memories, their impact on behaviors, and the differing responses seen in both healthy and diseased conditions. Utilizing a multidisciplinary approach, our research explores how experience-induced genetic programs establish connections between experiences and synaptic modifications within neural circuits, ultimately driving persistent behavioral changes.
Interventional psychiatry is treatment that combines brain stimulation with medication for difficult-to-treat mental health disorders. At UT Southwestern Medical Center, our psychiatrists have advanced training and expertise in caring for people with treatment-resistant mental health disorders.
We specialize in the latest advances in brain stimulation to bring relief to people who haven’t had success with traditional treatments.
We seek to understand how RNA/protein assemblies control cellular states, and how related pathways are hijacked by diseases of aging.
A major focus of the Patwardhan Lab is translational research into mechanisms of pain and potential treatment.
The Beckham lab is a dynamic multidisciplinary laboratory that studies viral pathogenesis and neuroimmune responses.
We aim to elucidate the role of the innate immune system in damage and repair following ischemic and hemorrhagic insults to the brain. We are specifically focused on innate immune drivers of secondary injury following aneurysmal subarachnoid hemorrhage and the immune response triggered by acute intracranial pressure spikes during aneurysm rupture. We also look into promoting recovery after ischemic stroke by reprogramming microglia and peripheral myeloid cells to drive repair. In addition, we are pursuing the development of therapeutics for intraarterial immunomodulation for chronic subdural hemorrhage.
Dr. LoBue's BRAIN lab, short for Brain Aging, Injury, and Modulation Lab, has two lines of research in the area of aging and neurodegenerative diseases. The lab investigates the later-in-life effects of traumatic brain injury, which involves understanding the potential risk associated with developing dementia and the underlying biological pathways. The lab also studies the effects of noninvasive brain stimulation in Alzheimer’s disease and related disorders with the goal of informing the development of new treatments.
Heart-Brain Connection Program
Our lab focuses on investigating the brain circuits implicated in treatment resistant depression with the ultimate goal of developing novel therapies for this devastating disease.
The focus of the Obata Lab is to study how environmental signals (e.g., microbiota, diet, day/night cycles) shape intestinal neural circuits and immune cell networks. A variety of experimental techniques are used, including state-of-the-art imaging technologies, viral tracing of gut innervation, in vivo and ex vivo physiological assays, gnotobiotic systems and multi-omics technologies. The Obata Lab is also interested in elucidating the molecular mechanisms of inter-organ communication, including the Gut-Brain axis.
